Sepideh Siadati; Majid Sharbatdaran; Novin Nikbakhsh; Naser Ghaemian
Abstract
Background and Objectives: Breast cancer is the most common malignancy among women in the world. The aim of this study was to assess estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu of infiltrating ductal carcinoma (IDC) with tumor size, histologic grade, lymph node metastasis and age. ...
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Background and Objectives: Breast cancer is the most common malignancy among women in the world. The aim of this study was to assess estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu of infiltrating ductal carcinoma (IDC) with tumor size, histologic grade, lymph node metastasis and age. Methods: This study was carried out on 300 tissue blocks ofpatients with IDC who underwent mastectomy from 2007 to 2011 in Shahid Beheshti Hospital, affiliated to Babol University of Medical Sciences, Babol, Iran. Data including age, tumor size, and histologic grade and lymph node status retrieved from pathology department. Result: Themean age of the patients was 40.2±2.3 (ranged 19-82 years). ER and PR were positively correlated with each other (P= 0.001) and they inversely correlated with HER-2/neu (P=0.001). We observed correlation between ER and PR expression and low histologic grade (P= 0.001) and HER-2/neu expression and high histologic grade (P= 0.003). There was correlation between HER-2/neu expression and lymph node involvement (P=0.03). None of these makers showed correlation with age and tumor size (P> 0.05). Conclusion: Our findings indicate the importance of ER, PR and HER-2/neu expression as prognostic factors for therapeutic decision. How to cite this article: Siadati S, Sharbatdaran M, Nikbakhsh N, Ghaemian N. Correlation of ER, PR and HER-2/Neu with other Prognostic Factors in Infiltrating Ductal Carcinoma of Breast. Iran J Pathol. 2015;10(3):221-6.
Novin Nikbakhsh1; Masomeh Bayani; Sepideh Siadati
Abstract
Background and Objectives: Sputum smear staining for acid-fast bacilli is initial approach to the diagnosis of pulmonary tuberculosis (PTB) but more than 50% of cases are sputum smear-negative. This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) guided bronchoalveolar ...
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Background and Objectives: Sputum smear staining for acid-fast bacilli is initial approach to the diagnosis of pulmonary tuberculosis (PTB) but more than 50% of cases are sputum smear-negative. This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) guided bronchoalveolar lavage (BAL) in patients suspected to have tuberculosis. Methods: This prospective cross-sectional study was carried out on 290 sputum smear-negative patients who were clinically suspicious for PTB in 2006-12. All patients were subjected to FOB andBAL, then BAL specimens stained and cultured. Results: Of the 290 patients, 173 cases (59.7%) were men and 117 cases (40.3%) were women with the age of 52.6±19.1 years (ranged 20-76 years). Of the total 290 BAL specimens, 110 specimens (38%) were positive for acid-fast bacilli. Sensitivity, specificity, PPV and NPV was 60%, 91%, 89% and 64%, respectively. Also, LR+ and LR- was 64.6% and 0.44%, respectively. Conclusion: FOB guided BAL is a reliable, rapid and useful method for establishing the diagnosis of smear negative PTB with minimal complications.
Maedeh Salehi; Mina Motallebnejad; Ramin Forooghi; Anahita Gorbani; Sepideh Siadati
Volume 9, Issue 3 , July 2014, , Pages 223-226
Abstract
Lipomais a most common benign neoplasm of mature adipose tissue in trunk and extremities. The oral cavity rarely affected by this neoplasm(1-4%) and more occurs in buccal mucosa. Floor of the mouth is rarely affected. Usually its size is less than 3 cm. The present report shows an unusual case of large ...
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Lipomais a most common benign neoplasm of mature adipose tissue in trunk and extremities. The oral cavity rarely affected by this neoplasm(1-4%) and more occurs in buccal mucosa. Floor of the mouth is rarely affected. Usually its size is less than 3 cm. The present report shows an unusual case of large lipoma (5.5 cm in greatest dimension) in the floor of the mouth of a 68- year- old male and review of the literature.
Abazar Akbarzadeh Pasha; Sepideh Siadati; Shahriar Shafaei; Vakili Sadeghi
Volume 9, Issue 2 , April 2014, , Pages 152-155
Abstract
Primary myeloid sacrom (MS) is a rare tumor and even more rare in multiple organs with no evidence of bone marrow involvement. This report describes an unusual case of a 19-year-old male presenting scrotal MS with a history of subconjunctival MS, 5 months ago. Bone marrow biopsies showed no evidence ...
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Primary myeloid sacrom (MS) is a rare tumor and even more rare in multiple organs with no evidence of bone marrow involvement. This report describes an unusual case of a 19-year-old male presenting scrotal MS with a history of subconjunctival MS, 5 months ago. Bone marrow biopsies showed no evidence of acute leukemia. Despite radiotherapy for first involvement and chemotherapy for second presentation, his condition deteriorated and he unfortunately died. This case is presented here to remind an unusual presentation of MS and to address that the pathologist should bear in mind the possibility of MS when making the differential diagnosis of unusual lymphoma or undifferentiated nonhematological tumors.
Sepideh Siadati; Nasibeh Khorram; Mohaddeseh Mirzapour
Volume 8, Issue 3 , July 2013, , Pages 159-164
Abstract
Background and Objectives: There are a few studies on histopathologic type of oral lesions especially from Iran. The aim of this study was to survey the oral lesions in Babol, northern Iran.
Methods: The histopathology records were retrospectively reviewed for all lesions of oral cavity and ...
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Background and Objectives: There are a few studies on histopathologic type of oral lesions especially from Iran. The aim of this study was to survey the oral lesions in Babol, northern Iran.
Methods: The histopathology records were retrospectively reviewed for all lesions of oral cavity and jaws, during the years 1990 to 2009. The data were collected from the archive of pathology and analyzed based on age, gender, site of lesion and histopathologic type.
Results: From the 465 studied specimens, the mean age was 34.6 ± 20.3 years old; female to male ratio was 1.1: 1. The most frequent lesions were inflammatory/reactive (60%), tumoral (25%), cystic (14.2%), and tumor like lesions (0.8%), respectively. The most common inflammatory lesion was mucocele as 54 cases (19.4%). Ameloblastoma was the most common odontogenic tumor (55.5%). The most common odontogenic cyst was radicular cyst (44.8%), and the most common non-odontogenic cyst was mucus retention cyst (75%).
Conclusion: It seems that the malignant oral and jaw lesions have been more prevalent in this study compared to others, thus, the patients must be biopsied earlier to rule out malignant oral lesion in histologic examination.
Masomeh Bayani; Sepideh Siadati; Seddigheh Esmaeilzadeh; Samaneh Asgari; Saeed Salmani
Volume 8, Issue 3 , July 2013, , Pages 171-177
Abstract
Background and Objectives: Chicken pox has potential complications during pregnancy for both the mother and her baby. The aim of this study was to determine the Varicella-zoster virus (VZV) immune status in pregnant women in Babol and its surrounding neighborhoods.
Materials and Methods: This seroepidemiological ...
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Background and Objectives: Chicken pox has potential complications during pregnancy for both the mother and her baby. The aim of this study was to determine the Varicella-zoster virus (VZV) immune status in pregnant women in Babol and its surrounding neighborhoods.
Materials and Methods: This seroepidemiological study was carried out on 427 pregnant women referred to Rohani Hospital, Babol, northern Iran from 2010 to 2011. The immune status (IgG level) was determined using ELISA method and correlation with age, place of residence, history of VZV infection and the number of siblings were evaluated.
Results: The mean age of the subjects was 27.16 + 5.7 years and their mean antibody level was 103.552 + 63.37 U/ml. Out of 427 pregnant women studied, 8.7% were seronegative, 1.2% were equivocal and 90.2% were seropositive. There was no correlation between age, the place of residence (urban or rural) and titer of antibody. However, higher antibody titer was found in women with more siblings.
Conclusion: Considering 90.2% of pregnant women were VZV seropositive, evaluation of VZV antibody in order to prevent complications in non-immune pregnant women and vaccination for women with age less than 25 years old and no VZV infection history, prior to pregnancy is recommended.
