Volume 19 (2024)
Volume 18 (2023)
Volume 17 (2022)
Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Molecular Pathology
Molecular Status of BRAF Mutation in Epithelial Ovarian Cancer: An Analysis of 57 Cases in the Northeast of Iran

Amirhossein Jafarian; Masoumeh Jafaripour; Masoumeh Gharib; Maryam Salehi; Nema Mohamadian Roshan; Sare Etemad; Khatoone Mirshekar; Maryam Sheikhi; Masoumeh Heidari; Behnaz Ahmadian; Zahra Khoshnegah; Hossein Ayatollahi; Payam Siyadat

Volume 18, Issue 2 , April 2023, , Pages 134-140


  Background & Objective: Epithelial ovarian cancer (EOC) is the most prevalent type of ovarian cancer. Previous studies have elucidated different pathways for the progress of this malignancy. The mutation in the B-Raf proto-oncogene, serine/threonine kinase (BRAF) gene, a member of the MAPK/ERK signaling ...  Read More

Evaluation of FLT3-ITD Mutations and MDR1 Gene Expression in AML Patients

ehsan yazdandoust; mohammad hadidi sadeghian; seyyede fatemeh shams; Yasaman Saadatpour; payam siyadat; maryam sheikhi; Monavar Afzal Aghaee; Hossein Ayatollahi

Volume 17, Issue 4 , October 2022, , Pages 419-426


  Background & Objective: Acute myeloid leukemia (AML) is a hematopoietic malignancy caused by genetic abnormalities. These days, molecular and genetic factors are usually used as diagnostic and prognostic markers. FLT-3 is one of the most known diagnostic factors in AML. MDR1 gene belongs to the ATP ...  Read More

Cytogenetic Studies of 608 couples with Recurrent Spontaneous Abortions in Northeastern Iran

Narjes Soltani; Farzaneh Mirzaei; Hossein Ayatollahi

Volume 16, Issue 4 , August 2021, , Pages 418-425


  Background & Objective: One of the major genetic causes of recurrent spontaneous abortions is parental chromosomal abnormalities. The objectives of the study were to determine, compare and analyze the incidence and distribution of chromosomal abnormalities in couples with recurrent miscarriages from ...  Read More

Biology & Genetic
Cytogenetic Study of Patients with Primary Amenorrhea in the Northeast of Iran

Narjes Soltani; Farzaneh Mirzaei; Hossein Ayatollahi

Volume 16, Issue 1 , January 2021, , Pages 57-61


  Background & Objective: Primary amenorrhea refers to the absence of menstruation in females of reproductive by age 16 when the development of secondary sexual characteristics is evident (breast development, pubic hair) or by age 14 when there are no secondary sexual characteristics are present. Primary ...  Read More

The Survival of Patients with t(15;17)(q22;q12) Positive Acute Promyelocytic Leukemia: A Study in North-East of Iran

Hossein Ayatollahi; Ali Bazi; Mohammad Hadi Sadeghian; Ali Fani; Payam Siyadat; Maryam Sheikhi; Omolbanin Sargazi-aval

Volume 15, Issue 3 , July 2020, , Pages 175-181


  Background & Objective: Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (AML).  Here, our objective was to ascertain the survival of patients with this leukemia in north-east of Iran. Methods:  Survival rates of ...  Read More

Molecular Pathology
Epstein-Barr Virus and Human Herpesvirus 8 in Idiopathic Pulmonary Fibrosis

Amir Hossein Jafarian; Nema Mohammadian Roshan; Hossein Ayatollahi; Abbas Ali Omidi; Masoumeh Ghaznavi; Masoumeh Gharib

Volume 15, Issue 1 , January 2020, , Pages 30-33


  Background & Objective:Idiopathic pulmonary fibrosis (IPF) is a chronic and uniformly fatal interstitial lung disease with incompletely understood pathogenesis. Several studies have given the evidence for and against viral cofactors in the pathogenesis of Idiopathic pulmonary fibrosis. In this study ...  Read More

Molecular Pathology
Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma

Amir Hossein Jafarian; Nema Mohammadian Roshan; Masoumeh Gharib; Vahid Moshirahmadi; Aida Tasbandi; Amir Ali Ayatollahi; Hossein Ayatollahi

Volume 14, Issue 2 , April 2019, , Pages 96-103


  Background and Objective: The primary goal of this study is to develop a rigorous understanding ofthe correlation between COX-2 expression and malignant melanoma prognostic factors. Material and Methods: In this cross-sectional study, we analyzed 60 cases of cutaneous malignant melanoma. The related ...  Read More

Prevalence of MPL (W515K/L) Mutations in Patients with Negative-JAK2 (V617F) Myeloproliferative Neoplasm in North-East of Iran

Seyyede Fatemeh Shams; Hossein Ayatollahi; Mohammad hadi Sadeghian; Monavar Afzal Aghaee; Sepideh Shakeri; Ehsan Yazdandoust; Maryam Sheikhi; Nafiseh Amini; Samane Bakhshi; Afsane Bahrami

Volume 13, Issue 4 , October 2018, , Pages 397-402

  Background and Objective: Janus kinase 2 (JAK2) and Myeloproliferative Leukemia (MPL) mutations are confirmatory indicators for Myeloproliferative Neoplasm (MPN). The current study was performed to determine the frequency of MPL mutation in MPN patients without JAK2 mutation, in order to assign MPL mutation ...  Read More

Diagnostic Pathology
Molecular Status of BRAF Mutation in Prostate Adenocarcinoma: The Analysis of 100 Cases in North-East of IRAN

Amir Hossein Jafarian; Khatoone Mirshekar; Sare Etemad; Masoumeh Jafaripour; Mansoore Darijani; Maryam Sheikhi; Hossein Ayatollahi; Sepideh Shakeri; Seyyede Fatemeh Shams; Saeed Davari

Volume 13, Issue 4 , October 2018, , Pages 415-421

  Background and Objective: BRAF mutations were studied in various populations for prostate carcinoma (PC); however, mutations in BRAF gene are unusual compared to KRAS. Oncogenic activating of BRAF mutations were studied lately in almost 0%-10% of prostate cancer cases. Methods: In this retrospective ...  Read More

Biology & Genetic
KRAS Codon 12 and 13 Mutations in Gastric Cancer in the Northeast Iran

Hossein Ayatollahi; Alireza Tavassoli; Amir Hossein Jafarian; Amin Alavi; Sepideh Shakeri; Seyyede Fatemeh Shams; Maryam Sheikhi; Neda Motamedi Rad; Mohammadhadi Sadeghian; Afsane Bahrami

Volume 13, Issue 2 , April 2018, , Pages 167-172


  Background & objective: KRAS mutations are reported in many types of cancers including pancreas, lung, colon, breast, and gastric (GC). High frequency of KRAS mutation is observed in the pancreas, colon, and lung cancers; they commonly arise in codon 12 and 13 of exon 2. Due to the lack of information ...  Read More

Biology & Genetic
The Association of Gastritis and Peptic Ulcer With Polymorphisms in the Inflammatory-related Genes IL-4 and IL-10 in Iranian Population

Meysam Rezaeishahmirzadi; Neda Motamedi Rad; Mehdi Kalantar; Hossein Ayatollahi; Sepideh shakeri; Maryam Sheikhi; Mohammad Shekari

Volume 13, Issue 2 , April 2018, , Pages 229-236


  Background and Objective: The current study aimed at assessing the relationship between gastritis and peptic ulcer susceptibility and inflammation-related gene polymorphisms in Iranian patients. Gastritis and peptic ulcer are common medical complications with serious outcomes on the quality of life. ...  Read More

Chromogenic in situ Hybridization Compared with Real Time Quantitative Polymerase Chain Reaction to Evaluate HER2/neu Status in Breast Cancer

Hossein Ayatollahi; Azar Fani; Ehsan Ghayoor Karimiani; Fateme Homaee; Arezoo Shajiei; Maryam Sheikh; Sepideh Shakeri; Seyyede Fatemeh Shams

Volume 12, Issue 2 , April 2017, , Pages 128-134


  Background and objective: The assessment of human epidermal growth factor receptor 2 (HER2) status has become of great importance in the diagnosis of breast cancer. The aim of this study was to investigate the diagnostic value of quantitative Polymerase Chain Reaction (qPCR) and Chromogenic In Situ Hybridization ...  Read More

Fluorescent in Situ Hybridization and Real-Time Quantitative Polymerase Chain Reaction to Evaluate HER-2/neu Status in Breast Cancer

Fatemeh Homaei Shandiz; Azar Fani; Sepideh Shakeri; Maryam Sheikhi; Abouzar Ramezani Farkhani; Arezoo Shajiei; Hossein Ayatollahi

Volume 12, Issue 1 , January 2017, , Pages 67-73


  Background:Breast cancer remains the most common and second lethal cancer in females. HER-2/neu is one of the most important amplified oncogene in breast cancer. The amplification of HER-2 is correlated with decreased survival, metastasis, and early recurrence.  The amplification of HER-2/neu gene ...  Read More

C3 and C4 Complement Levels in Iron Deficiency Anemia

Mohammad Reza Keramati; Mohammad Hadi Sadeghian; Hossein Ayatollahi; Houshang Rafatpanah; Mohammad Khajeh Daluei; Nafise Baesi

Volume 6, Issue 2 , April 2011, , Pages 56-62

  Background and Objectives: Complement proteins are some of the most important plasma proteins of the innate immune system. Impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. This study was conducted to show whether ...  Read More

Evaluation of Serum PSA in Different Storage Environments

Mohammad Hassan Ghosian Moghaddam; Hossin Ayatollahi; Fatemeh Ghafarirad; Maryam Maleki; Ali Davati

Volume 5, Issue 4 , September 2010, , Pages 173-177

  Background and Objective: Prostate cancer is a prevalent disease around the world. The prostatic specific Antigen (PSA) test has recently proved itself as a useful method for the diagnosis and examination of patients with prostatic cancer. The objective of this study was to compare the stability of free ...  Read More

Cytogenetic Analysis of Patients with Primary Amenorrhea in Southwest of Iran

Hossein Ayatollahi; Akbar Safaei; Mohammad Vasei

Volume 5, Issue 3 , June 2010, , Pages 121-126

    Background and Objectives: Primary amenorrhea is not a disease but a symptom that may result from several quite different causes[NN1] . Common hormonal cause of primary amenorrhea includes constitutional delay, hypothalamic –pituitary dysfunction, chronic systemic disease and absent ...  Read More

A Comparative Study on Instrumental Precision of Refrigerated and Non-Refrigerated Auto-Analyzers in Order to Improve Quality Assurance in Biochemistry Laboratory

Hossein Ayatollahi; Tayyebeh Kianoush; Nema Mohammadian Roshan

Volume 2, Issue 3 , June 2007, , Pages 94-96

  Background and Objective: Quality control is one of the most important components in order to improve quality assurance in laboratories during analytical steps. For this purpose, coefficient of variation plays an important role. Due to the fast improvement in technology, application of inferential statistics ...  Read More

Serum Level of High Sensitive C-Reactive Protein in Normal and Preeclamptic Pregnancies

Hossein Ayatollahi; Maliheh Hasanzade; Mahdi Farzadnia; Mahdi Khabbaz Khoob; Atefeh Rahmanian

Volume 2, Issue 3 , June 2007, , Pages 100-104

  Background and Objective: The aim of this study was to determine the level of plasma high sensitive c-reactive protein (hs-CRP) in preeclampsia and to compare hs-CRP levels between normal pregnant women, mild preeclamptic, and severe preeclamptic women. Materials and Methods: Serum hs-CRP levels were ...  Read More

Evaluation of the total analytical error in the flame photometry method

Hossein Ayatollahi; Tayebeh Kianoush; Mohammad Khajeh Daluee

Volume 1, Issue 2 , April 2006, , Pages 65-68

  Background and Objectives: For total analytical error, imprecision (SD) and bias, performance goals for laboratory tests have most often been developed. A total analytical error goal requires that the combination of errors from all sources (random and systematic errors) be within some acceptable limit. ...  Read More