Frequency of Group B Streptococcal Colonization in Pregnant Women Aged 35-37 Weeks in Clinical Centers of Shahed University, Tehran, Iran

Document Type: Original Research

Authors

1 Dept. of Obstetrics and Gynecology, Shahed University, Tehran, Iran

2 Dept. of Health and Social Medicine, Shahed University, Tehran, Iran

10.7508/ijp.2015.02.006

Abstract

Background & Objectives: One of the important infectious factors in pregnant mothers and newborns is Group B Streptococcus (GBS). There is no perfect report about prevalence of GBS in Iran and in the case of preterm rupture of amniotic membrane or preterm labor all patients are treated by antibiotics without culture so this has led to adverse taking antibiotics and drug resistance. The present study is intended to determine the frequency of colonization of GBS in the pregnant mother (35-37 weeks), referred to medical centers of Shahed University. Methods: Overall, 210 pregnant women (35-37 weeks), referred to medical center of Shahed University, Tehran, Iran were selected as sample group and after filling out the questionnaires about demographic data and midwifery status and the related information of post- partum, the rectovaginal culture was done for them. Results: Among 210 samples, 7 (3.3%) included positive culture in terms of GBS colonization while all these cases were sensitive to penicillin, ampicillin, cephalothin, nitrofurantoin, and all of the samples were resistant against tetracycline and contrimoxazole. There was no relationship among age, job, education, number of pregnancy, blood pressure background, diabetes and preterm childbirth with positive culture. Similarly, because of limited number of positive cases it was not possible to examine the relationship among GBS colonization and infection in mother and newborn. Conclusion: There was a low frequency in GBS colonization in the studied hospitals and the study inside the country also confirms this finding.

Keywords


  1. Davis JK, Gibbs RS, editors. Danforth’s Obstetrics and Gynecology. 10thed. New York: Lippincott Williams & Wilkins;2008.
  2. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, RouseDJ, Rouse DJ, et al.Williams Obstetrics. 23rded. New York: McGrow-Hill Companies; 2010.
  3. Artz LA, Kenpf VA, Authenrieth IB. Rapid screening for streptococcus agalactiae in vaginal specimens of pregnant women by fluorescent in situ hybridization. J Clin Micobial 2003; 41(5):2170-3.
  4. Pergeron MG, Ke D. New DNA- based PCR approaches for rapid real-time detection and prevention of group B streptococcal infections in newborns and pregnant women. Expert Rev Mol Med 2001:8;3(27):1-14.
  5. Bergh K, Stoelhaug A, Loeseth K, Bevanger L, detection of group B streptococci(GBS) in vaginal swabs using real- time PCR with Taqman probe hybridization. Indian J Med Res 2004; 119 Suppl:221-3.
  6. Das A, Ray P, Sharma M, Gopalan S. Rapid diagnosis of vaginal carriage of group B beta hemolytic streptococcus by an enrichment cum antigen detection test. Indian J Med Res 2003; 117: 247-52.
  7. Sarafaraz N, Mesdaghi E, Moniri R, Moosavi SGA. The  review  of  vaginal  floral  prevalence  of  hemolytic Streptococcusgroup B in pregnant women and its relationship with neonatal preterm sepsis and infections during pregnancy period. Feiz 2001; (2) 5: 22-7.
  8. Garland SM, Kelly N, Ugoni AM. Is antenatal group B streptococcal carriage a predictor of adverse obstetric outcome? Infect Dis Obstet Gynecol 2000; 8(3-4): 138-42.
  9. Vijayan Sh, Noyal MJ, Thirunavukkarasu AB, Latha Ch, Sujatha S. Genital tract group B streptococcal colonization in pregnant women: a South Indian perspective. J Infect Dev Ctries 2011; 5(8):592-5.
  10. Piper JM, Georgious S, Xenakis EM, Langer D. Group B Streptococcusinfection rate unchanged by gestational diabetes. Obstet Gynecol 1999; 93(2): 292-6.
  11. Colbourn T, Gilbert R. An interview of the natural history of early onset group B streptococcal disease in the UK. Early Hum Dev 2007; 83(3): 149- 56.
  12. Petterson K. Perinatal infection with group streptococci, 2007; 193-7 [http://www.$ Sciencedirect.com.Accessed 2010].
  13. Sharmila V, Joseph NM, Arun Babu T, Chturveduka L, Sistla S. Genital tract group B streptococcal colonization in pregnant women: a south Indian perspective. J Infect Dev Ctries 2011; 5(8): 592-5.
  14. Zamzami TY, Marzouki AM, Nasrat HA. Prevalence rate of group B streptococcal colonization among women in Labpor at king Abdul-Aziz University Hospital. Arch Gynecol Obstet. 2011; 284(3): 677-9.
  15. Stapleton RD, Kahn JM, Evans LE, Critchlow CW, Gardella CM. Risk factors for group B streptococcal genitourinary tract colonization in pregnant women. Obstet Gynecole 2005; 106(6): 1246-52.
  16. Schrag S, Growitz RA, Fultz-Butts KR, Schuchat An. Prevention of perinatal group B streptococcal disease. MMWR. 2002; 51 (11): 1-22.
  17. Ohlasson A, Shah VS. Intrapartum antibiotis for known maternal group B streptococcal colonization. Cochrane database Syst Rev 2009; (3): CD007467.
  18. Shayanfar N, Mohammadpour M, HashemiMoghadam SA, Haghi Ashtiani MT, Zare Mirzaie A, Rezaei N. Group B streptococci urine isolates and their antimicrobial susceptibility profiles in a group of Iranian females : Prevalence and seasonal variations. Acta Clin Croat 2012;51(4):623-6.
  19. Abarzua F, Arias A, Garcia P, Ralph C, Cedra J, Riedel I, et al.  Streptococcusagalactiae increase in resistance to erythromycin and clindamycin in vaginal- anal colonization in third quarter of pregnancy in one decade of universal screening. Rev Chilena infectol 2011; 28(4): 334-7.