Document Type: Original Research

Authors

1 Dept. of Pathology, Bandarabas University of Medical Sciences, Bandarabas, Iran.

2 Dept. of Gynecology and Obstetrics, Bandarabas University of Medical Sciences, Bandarabas, Iran.

3 Dept. of Educational Medicine, Bandarabas University of Medical Sciences, Bandarabas, Iran.

4 Dept. of Genetics, Bandarabas University of Medical Sciences, Bandarabas, Iran.

Abstract

  Background and Objective: To estimate the risk of human papilloma virus (HPV) infection for cervical malignancies, we conducted a case-control study in southern Iran (Hormozgan province). Materials and Methods: For this purpose,52 paraffin embedded blocks with exact diagnosis of cervical carcinoma(50 carcinomas and 2 carcinomas in situ) from 2001 to 2006 and 52 praffin embedded blocks of cervical tissue specimens with normal histopathology as the control group were tested for the presence of HPV DNA using PCR based assay. Results: HPV DNA was found out in 16 out of 52 patients (30.7%), while it was not detected in any of the control group samples. Conclusion: Considering the fact that unrestrained sexual behavior increases risk of becoming infected with HPV, our finding is in favor of the concept of low frequency of HPV infection and thus its less important role in women with cervical cancer in islamic countries.  

Keywords