Document Type: Original Research

Authors

1 Department of Physiology, School of Medicine, Shahed University, Tehran.

2 Department of Anatomy, School of Medicine, Iran University of Medical Sciences and University of Social Welfare and Rehabilitation (USWR), Tehran.

3 Department of Pathology, School of Medicine, Shahed University, Tehran.

4 Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran

5 Department of Internal Medicine, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord.

Abstract

Background and Objective: Although diabetes mellitus is known to be one of the risk factors for dementia but neuropathic changes in the brain of diabetic patients have not been completely revealed. Therefore, this research study was done to evaluate structural changes in pyramidal neurons of hippocampal CA1 area of male diabetic rats using Golgi-impregnation method. Materials and Methods: Male Wistar rats were randomly divided into control and diabetic groups. For induction of diabetes, streptozotocin (STZ) was injected (i.p.) at a single dose of 60 mg/kg. At the end of 1st and 2nd months, rats were transcardially perfused and Golgi-impregnation method was used to evaluate the changes of dendritic spines in CA1 area. Results: It was found out that there was a significant reduction in mean density of pyramidal neuron dendritic spines after 1 and 2 months in diabetic group as compared to age-matched controls (p  

Keywords