Since its original conception in 1959, by Nobel physicist Richard P Feynman, the notion of nanotechnology and its potential ramifications have not only created fascination,but also intense scientific efforts and scrutiny. One of the most promising applications of nanotechnology is in the context of medicine. Due to their unique size-dependent properties nanomaterials such as nanoparticles offer the possibility to develop both new therapeutic and diagnostic tools. This applied nanotechnology to medical problems has been proposed as nanomedicine by NIH. Nanomedicine can offer new concepts that are reviewed. Specific attention is given to the development and basic approach of this new technique and give some principle definition of nanosized-particle and its application in treatment, diagnosis, monitoring and control of biological system. The future of nanomedicine and their applications of diseases of different organs will be reviewed later.