• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Staff
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Iranian Journal of Pathology
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 14 (2019)
Volume Volume 13 (2018)
Volume Volume 12 (2017)
Volume Volume 11 (2016)
Volume Volume 10 (2015)
Volume Volume 9 (2014)
Volume Volume 8 (2013)
Volume Volume 7 (2012)
Volume Volume 6 (2011)
Volume Volume 5 (2010)
Volume Volume 4 (2009)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 3 (2008)
Volume Volume 2 (2007)
Volume Volume 1 (2006)
Saderi, H., Owlia, P., Eslami, M. (2009). Prevalence of Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance in S. aureus Isolated from Patients in Tehran, Iran. Iranian Journal of Pathology, 4(4), 161-166.
Horieh Saderi; Parviz Owlia; Maryam Eslami. "Prevalence of Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance in S. aureus Isolated from Patients in Tehran, Iran". Iranian Journal of Pathology, 4, 4, 2009, 161-166.
Saderi, H., Owlia, P., Eslami, M. (2009). 'Prevalence of Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance in S. aureus Isolated from Patients in Tehran, Iran', Iranian Journal of Pathology, 4(4), pp. 161-166.
Saderi, H., Owlia, P., Eslami, M. Prevalence of Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance in S. aureus Isolated from Patients in Tehran, Iran. Iranian Journal of Pathology, 2009; 4(4): 161-166.

Prevalence of Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance in S. aureus Isolated from Patients in Tehran, Iran

Article 4, Volume 4, Issue 4, Summer 2009, Page 161-166  XML PDF (173.84 K)
Document Type: Original Research
Authors
Horieh Saderi email ; Parviz Owlia; Maryam Eslami
Dept. of Microbiology, Shahed University, Tehran, Iran
Abstract
Background and Objectives: Staphylococcus aureus is an important cause of nosocomial and community-acquired infections in every region of the world. Clindamycin is one of the alternative agents used to treat S. aureus infections and accurate identification of clindamycin resistance is important to prevent therapeutic failure. Unfortunately, inducible clindamycin resistance is not detected by standard susceptibility tests. This study aimed to determine the prevalence of the macrolides-lincosamides-streptogramins B (MLSB) resistance in S. aureus isolated in four university hospitals in Tehran, Iran. Material & Methods: Two hundreds and forty-four non-duplicate clinical isolates of S. aureus (133 methicillin resistant S. aureus (MRSA) and 111 methicillin susceptible (MSSA) S. aureus) were collected in 2008. Antimicrobial susceptibilities were determined by the D-test. Results: Altogether, 68% and 61.1% of isolates were resistant to erythromycin and clindamycin, respectively; with higher resistance in MRSA isolates compared to MSSA isolates. The constitutive MLSB (cMLSB) resistance phenotype was recognized in 61.1%, while 5.3% had shown inducible MLSB (iMLSB) resistance phenotype. Constitutive MLSB resistance phenotype predominated over inducible MLSB resistance phenotype and susceptible phenotype (83.9, 9.3 and 6.8%, respectively) among the MRSA isolates, whereas susceptible phenotype predominated over constitutive MLSB resistance phenotype and inducible MLSB resistance phenotype (62.6, 31.3 and 2%, respectively) among the MSSA isolates.  Conclusion:Considering the higher prevalence of clindamycin resistance in MRSA isolates compared MSSA isolates, routine D-test of MRSA isolates is strongly recommended to prevent treatment failure.  
Keywords
Macrolides; Lincosamide; Streptogramin B; Prevalence; Antibiotic resistance; Staphylococcus aureus
Statistics
Article View: 1,901
PDF Download: 1,025
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Creative Commons License
IRANIAN JOURNAL OF PATHOLOGY by Iranian Society of Pathology is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Based on a work at http://ijp.iranpath.org/.

Journal Management System. Designed by sinaweb.