HIV-related Immunosuppression significantly increases the risk of acquiring opportunistic infections. This report describes a 69-year-old man, referred to hospital with decreased consciousness and productive cough. This man was a known case of human immunodeficiency virus positive. The sputum of this patient was positive for Salmonella typhimurium. Pulmonary auscultation signaled brief and scattered crackles especially in the lung bases. Lung graphy showed bronchopulmonary infiltration. Diagnosed with pneumonia due to Salmonella, the patient underwent treatment but he succumbed after 48 hours in septic shock. This case report demonstrates the importance of including general medical causes of immunosuppression and their treatment in the differential diagnosis and aetio-pathogenesis of HIV-infected patients with unusual clinical presentations.