Human papillomavirus (HPV) is one of the most common causes of sexually transmitted diseases worldwide and is the etiological agent of cervical and other anogenital malignancies. Since HPVs have been shown to possess oncogenic potential, an association between HPV infection and prostatic cancer (PCa) has been suggested. There are conflicting reports on the impact of HPV infection on the development of prostate cancer. The aim of this article is to review the studies that investigated the association between HPV and PCa. The results of this review demonstrated the divergent frequencies of HPV positivity in PCa in different geographic areas.