Borderline Ovarian Serous Adenofibromatous tumor with Prominent Micropapillary Pattern

Document Type: Case Reports

Authors

Dept. of Pathology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Ovarian borderline serous tumors are uncommon. Combination of borderline serous adenofibromatous tumor and prominent micro papillary architecture is not previously reported. We report a case of borderline papillary serous adenofibromatous tumor (also called serous adenocarcinofibroma) with extensive micropapillary pattern in a 27 year-old married woman. She was infertile and presented with diffuse abdominal pain and dysparonia. Bilateral 5.3 and 4.5 cm solid ovarian masses were detected by sonography. Both masses were ovoid with tan-pink bosselated smooth external surfaces, and solid tan lobular cut surfaces. Microscopically, both tumors showed many papillary structures in a fibrotic stroma and contained multiple psammoma bodies. The papillae had broad hyalinized fibrotic stroma with many micropapillary projections arising from the main papilla, lined by mildly pleomorphic cuboidal cells. Mitotic activity was low with no marked nuclear atypia or stromal invasion. No extraovarian implants or metastases were identified.

Keywords


  1. Rosai J. Rosai and Ackerman's surgical pathology. 9th ed. New York: Mosby; 2004.
  2. Ookura N, Nishida T, Ushijima K, Muraoka Y, Ohbuchi M, Sugiyama T, et al. Serous adenocarcinofibroma of the ovary--report of two cases and review of the literature. Kurume Med J 1999;46(2):133-6.
  3. Kurman R, Ellenson L, Ronett B. Blaustein's Pathology of the female genital tract. 9th ed. New York: Springer; 2011.
  4. Mills S, Carter D, greenson J, Oberman H, Reuter V, Stoler M. Sternberg's Diagnostic surgical Pathology. 411th ed. Philadelphia: Williams & Wilkins; 2040.
  5. Scully RE, Young RH. William B. Ober, MD (1920-1993): humanist, humorist, historian, and histopathologist: recollections of his life and evaluation of his work. Semin Diagn Pathol 2008;25(3):202-29.
  6. Longacre TA, McKenney JK, Tazelaar HD, Kempson RL, Hendrickson MR. Ovarian serous tumors of low malignant potential (borderline tumors): outcome-based study of 276 patients with long-term (> or =5-year) follow-up. Am J Surg Pathol 2005;29(6):707-23.
  7. Freedman SI. Adenofibrocarcinoma of the ovary. Atypical histologic patterns in four patients. Obstet Gynecol 1972;39(5):795-801.
  8. Crum C, LEE K, Genest D, Granter S, Haefner H, Mutter J, et al. Diagnostic Gynecologic and Obstetric Pathology. 1st ed. Philadelphia: Saunders; 2006.
  9. Silverberg SG, Bell DA, Kurman RJ, Seidman JD, Prat J, Ronnett BM, et al. Borderline ovarian tumors: key points and workshop summary. Hum Pathol 2004;35(8):910-7.
  10. Seidman JD, Soslow RA, Vang R, Berman JJ, Stoler MH, Sherman ME, et al. Borderline ovarian tumors: diverse contemporary viewpoints on terminology and diagnostic criteria with illustrative images. Hum Pathol 2004;35(8):918-33.
  11. Roma A, Malpica A, Deavers M, Silva E. Ovarian seous borderline tumors with a prominent micropapillary pattern are aggressive neoplasms with an increaded risk for low grade serous carcinoma. Modern Pathol 2008;21:221A.