Document Type: Original Research
Dept. of Pathology, Qazvin University of Medical Sciences, Qazvin, Iran
Background and Objectives: Accelerating wound healing is a very important factor for patients to return to ordinary life. Laser seems to have positive effect on cutaneous wound healing. This study aimed to investigate the effect of red light laser 630 nm on cutaneous surgical wound in hamster and to compare outcomes such as angiogenesis, number of fibroblasts and collagen formation in intervention and control group.
Materials and Methods: This experimental study carried out with collaboration of Qazvin University of Medical Sciences with Mehregan Pet Clinic in winter of 2009. Thirty suri hamsters were randomly allocated in two groups and four parallel wounds were made on their backs. The intervention group was radiated with red-light laser 630 nm. After 2,5,10 and 14 days, skin biopsy were obtained and number of blood vessels, fibroblast and collagen production were compared with the control group. Data were analyzed using independent sample student t test using SPSS version 10 and P value less than 0.05 was considered significant.
Result: Evaluation of wounds in experimental and control groups showed significantly increased number of vessels and fibroblasts as well as collagen production in laser radiating group (P<0.05).
Conclusion: Laser therapy (630 nm) can accelerate wound healing in comparison with control group.
- Houreld N, Abrahamse H. Low-level laser therapy for diabetic wound healing. Source: The diabetic foot, Date: 12/22/2005, Available online AT: http://www.mylightwave.com/docs/HighBeamResearch%20Low-level%20laser%20therapy%20for%20diabetic%20foot%20wound%20healing._Wound%20care_.pdf. Last accessed 22 Dec 2011.
- Bolton P, Dyson M, Young S. The effect of polarized light on the release of growth factors from the U-937 macrophage – Like cell line. Laser Ther 1992;4(1):33-8.
- Dyson M, Young S. Effect of Laser Therapy on Wound Contraction and Cellularity in Mice. Lasers Med Sci 1986;1(2):125-30.
- Kumar V, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Diseases. 8th ed. Saunders:New York;2007.
- Walsh LJ. The current status of low level laser therapy in dentistry. Part 1. Soft tissue applications. Aust Dent J 1997;42(4): 247-54.
- Tunér J, Hode L. laser therapy: Clinical practice and scientific background. 1st Sweden:Prima books;2002.
- Pinheiro AL, Carneiro NS, Vieira, AL, Brugnera A Jr, Zanin FA, Barros RA, et al. Effects of low level laser therapy on malignant cells in vitro study. J Clin Laser Med Surg 2002;20(1):23-6.
- Ohshiro T, Calderhead RG. Progress in low-level laser therapy. John Wiley &Sons: England;1991.
- Steinlechner CWB, Dyson M. The effects of low level laser therapy on the proliferation of keratinocytes. Laser Ther 1993;5:65-73.
- Loeveschall H, Arenbolt-Bindslev D. Effect of low-level diode laser irradiation of human oral mucosa fibroblasts in vitro. Laser Surg Med 1994; 14(4):347-54.
- Reddy GK, stehnoBittel L, Enwemeka CS. Laser photostimulation accelerates wound healing in diabetic rats. Wound Repair Regen 2001; 9(3):248-55.
- YU W, Naim JO, lanzafame RJ. Effects of photostimulation on wound healing in diabetic mice. Laser Surg Med 1997;20(1):59-63.
- Matić M, Lazetić B, Poljacki M, Duran V, Ivkov-Simić M. Low-level laser irradiation and its effect on repair processes in the skin. Med Pregl 2003; 56(3-4):137-41.
- 14-HamblinMR.Mechanism of low-level light therapy. Available online at www.mgh.harvard.edu/wellman/people/mhamblin.asp