To introduce the most easy to perform blood glucose investigation can help management of diabetes mellitus. The point of care testing (POCT) technology is widely used and there are many new introduced techniques (1). The AccuCheck Inform II is a new technique with use of a mutated glucose dehydrogenase that has no problem of cross-reaction to maltose (2). The previous report showed that this new tool is acceptable for clinical use. Here, the authors perform a study on the accuracy and precision of the AccuCheck Inform II comparing to Lab Cobas 6000, a standard clinical chemistry analyzer (N = 2- for both accuracy and precision study). Focusing on our results, all samples pass the evaluation criteria (accuracy more than 90% and imprecision less than 10%). It can be seen that the results support the previous report by Dietzen et al. (2). Nevertheless, there are still more concerns for further evaluation. First, the cost effectiveness of the new technique comparing to the classical tool has to be studied. Second, although the new technique has decreased problem of laboratory interference, there is still a report on the concerned interference from icodextrin metabolites (3).