Document Type: Original Research

Authors

1 In fectious Disease and Tropical Research center, Babol University of Medical Sciences, Babol, Iran

2 Dept. Of Pathology, Babol University of Medical Sciences, Babol, Iran

Abstract

Background & Objectives: Hepatitis B is one of the major health problems in the world. Health care workers (HCWs) are at high risk of acquiring hepatitis B virus. The aim of this study was to evaluate the prevalence of HBV infection and the immune response to HBV vaccine among the HCWs in Babol, northern Iran. Methods: This study was accomplished on 527 HCWs and administrative staff working at Rohani Hospital, Babol, northern Iran from 2011 to 2012. HBs- Ag, HBc- Ab and HBs- Ab were measured by ELISA method. All susceptible staff vaccinated with recombinant hepatitis B vaccine (Pasteur Institute of Iran) and HBs - Ab titer was evaluated 3 months after the last dose. Results: Anti-HBc was positive in 32 (6.1%) and HBs-Ag in 4 (0.75%) of the participants. The HBV exposure in HCWs was four times greater than the administrative staff (6.65% vs. 1.63%). There was significant association between HBV exposure and occupation and also educational level (P < 0.001), however, this association was not found with age and gender. Seroconversion was seen in 211 (91.7%) of 230 participants who received three-dose series of hepatitis B vaccine. The seroconversion is significantly decreasing by the increase of age (P < 0.001), however, no significant association was seen with age and gender. Conclusion: Considering high HBV infection exposure in HCWs, it is mandatory to ensure vaccination program and postvaccination evaluation along with education and safe work environment preparation.

Keywords

  1. Adibi P, Rezailashkajani MR, Roshandel D, Behrouz N, Ansari SH, Somi MH, et al. An economic analysis of premarriage prevention of hepatitis B transmission in Iran. BMC Infect Dis 2004;4:31.
  2. Memon AR, Shafique K, Memon A, Draz AU, Rauf MU, Asfar S. Hepatitis B and C prevalence among the high risk groups of Pakistani population. A cross sectional study. Arch Public Health 2012;70(1):9.
  3. Leuridan E, Damme P. Hepatitis B and the Need for a booster dose. Clin Infect Dis 2011;53(1):68-75.
  4. Zuckerman JN, Zuckerman AJ, Symington I, Du W, Williams A, Dickson B. Evaluation of a new hepatitis B triple-antigen vaccine in inadequate responders to current vaccines. Hepatology 2001:34(4):798-802.
  5. Ziraba AK, Bwogi J, Namale A, Wainaina CW, Mayanja-Kizza H. Sero-prevalence and risk factors for the hepatitis B virus infection among health care workers in a tertiary hospital in Uganda. BMC Infect Dis 2010;10:191.
  6. Zamani F, Fallahian F, Hashemi F, Shamsaei Z, Alavian SM. Immune response to hepatitis B vaccine in Health-care workers. Saudi J Kidney Dis Transpl 2011;22(1):179-84.
  7. Wicker S,Jang J, Winn R, Gottschalk R,Rabenau F. Prevalence and prevention of needle stick injuries among health care workers in a germane university hospital. Int Arch Occup Environ Health 2008;81:347-54.
  8. Pellissier G, Yazdanpanah Y, Adehossi E, Tosini W, Madougou B, Ibrahima K, et al. Is universal HBV healthcare workers a relevant strategy in developing endemic countries? The case of a university hospital in Niger. PLoS One 2012;7(9):e44442.
  9. Bahmani MKh, Khosravi A, Mobasser A, Ghezalsofla E. Seroprevalence of hepatitis B virus infection and vaccination compliance among health care workers in Fars province, Iran. IJCID 2010;5(1):45-50.
  10. Shin BM, Mi Yoo H,Lee AS, Park SK. Seroprevalence of Hepatitis B virus among health care workers in Korea. J Korean Med Sci 2006;21(1):58-62.
  11. Ciorlia LA, Zanetta DM. Hepatitis B in healthcare workers: prevalence, vaccination and relation to occupational factors. Braz J Infect Dis2005;9(5):384-9.
  12. Kumar AKK, Baghel PK, Shukla CB,Jain MK. Prevalence of hepatitis-B surface antigen (HBs-Ag) among health care workers.Indian J community Med 2000;25(2):93-6.
  13. Sohrabi MD, Sarafha J, Zolfaghari P,Eskandari Z. HBs Ab level in clinical personnel of Immam Hosein Hospital of Shahrood. Sci J Blood Tranofus Organ 2009;6(1):65-9.
  14. Singhal V, Bora D, Singh S. Prevalence of hepatitis B virus infection in healthcare workers of a tertiary care center in India and their vaccination status. J Vaccines Vaccine 2011;2(2).
  15. Khosravani A,Sarkari B, Negahban H, Sharifi A,Akbartabar Toori M,Eilami O.Hepatitise B infection among high risk population:a seroepidemiological survey in southwest of Iran.BMC Infec Dis 2012;12:378.
  16. Janbakhsh A, Sayad B, Vaziri S, Aieni P. Serologic response to hepatitis B vaccine in health care workers, Kermanshah, Iran. JRMS 2005;10(3):147-9.
  17. Varshochi M, Mahmodian R. Immunologic response to Hepatitis B vaccine in Health Care Workers: A screening progrom and evaluation of some host-related factors role. Am J Immunol 2011;7(1):12-6.
  18. Lok AS,Lai CL,Wu PC. Prevalence of isolated antibody to hepatitis B core antigen in an area endemic for hepatitis B virus infection: implications in hepatitis B vaccination programs. Hepatology1988;8(4):766-70.