2024-03-29T14:39:20Z
https://ijp.iranpath.org/?_action=export&rf=summon&issue=1355
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Plasmapheresis- Review Article
Alireza
Abdollahi
Plasmapheresis, which is defined as the removal of plasma, can be either "adjusted plasma" or “exchange of plasma”. The former is defined as selective withdrawal of certain (un)-pathological plasma components in different ways such as perfusion and then returning the remained donor plasma to him, the latter is non-selective removal of all components of plasma to provide blood products for injection into patients or to be used as the input of blood transfusion refinery or to remove the pathogen contained plasma before compensating for the volume losses with an equal volume of plasma or more commonly, replacing plasma with a substitute fluid (colloid or crystalloid) such as albumin. Plasmapheresis was divided generally into two groups:
1- Plasma products by donor plasmapheresis
2- Therapeutic plasmapheresis
Therapeutic plasma exchange or TPE are often attributed to plasma that exit from the body of patient then compensated by any kind of replacement fluid volumes to support neurmolemic situation of patients. Plasmapheresis is currently used as a therapeutic modality in a wide array of conditions. Generally, plasmapheresis is used when a substance in the plasma, such as immunoglobulin, is acutely toxic and can be efficiently removed. Myriad conditions fall under this category, including neurologic, hematologic, metabolic, dermatologic, rheumatologic, and renal diseases, as well as intoxications, that can be treated with plasmapheresis.
Plasmapheresis
Exchange the Plasma
2014
07
01
167
180
https://ijp.iranpath.org/article_7153_7e294693633b34482f2e51eca771a4a9.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Pathologic Lesions of Liver, Kidney and Lung in the Autopsy of 100 Mustard Gas-Exposed Iranian War Veterans
Nahid
Kazemzadeh
Alireza
Kadkhodaei
Babak
Soltani
Siamak
Soltani
Sahar
Rismantab Sani
Background & Objectives: Respiratory, central nervous system, and skin complications of mustard gas toxicity have previously been studied; however, the liver and kidney side effects due to this intoxication have not been fully noted. We aimed to evaluate the frequency of liver, kidney and lung lesions in mustard gas-exposed Iranian veterans who had been exposed to the toxin almost 2 decades before.
Methods: A total of 100 veteran bodies underwent autopsy by at least two forensic medicine specialists. The liver, kidney and lung specimens were sent for pathological examination and their lesions, severity of the lesions, and the relation between the type/severity of the lesions and the time elapsed since their appearance were studied.
Results: A total of 83%, 63%, and 62% of the veterans had lung, liver, and kidney pathologies. The most common pathologies included liver steatosis, interstitial fibrosis of the kidney, and lung atelectasis.
Conclusion: Liver and kidney pathologies are far more common than what is considered in the mustard gas-exposed veterans. These pathologies are often accompanied by very severe lung complications.
Sulfur mustard
Autopsy
Lung
Liver
Kidney
pathology
2014
07
01
181
186
https://ijp.iranpath.org/article_7155_7251a1e3b1ac612b51aed901d052e032.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Hepatitis B Infection: Prevalence and Response to Vaccination among Health Care Workers in Babol, Northern Iran
Masomeh
Bayani
Sepideh
Siadati
Mahmoud
Hajiahmadi
Afshin
Khani
Navid
Naemi
Background & Objectives: Hepatitis B is one of the major health problems in the world. Health care workers (HCWs) are at high risk of acquiring hepatitis B virus. The aim of this study was to evaluate the prevalence of HBV infection and the immune response to HBV vaccine among the HCWs in Babol, northern Iran. Methods: This study was accomplished on 527 HCWs and administrative staff working at Rohani Hospital, Babol, northern Iran from 2011 to 2012. HBs- Ag, HBc- Ab and HBs- Ab were measured by ELISA method. All susceptible staff vaccinated with recombinant hepatitis B vaccine (Pasteur Institute of Iran) and HBs - Ab titer was evaluated 3 months after the last dose. Results: Anti-HBc was positive in 32 (6.1%) and HBs-Ag in 4 (0.75%) of the participants. The HBV exposure in HCWs was four times greater than the administrative staff (6.65% vs. 1.63%). There was significant association between HBV exposure and occupation and also educational level (P < 0.001), however, this association was not found with age and gender. Seroconversion was seen in 211 (91.7%) of 230 participants who received three-dose series of hepatitis B vaccine. The seroconversion is significantly decreasing by the increase of age (P < 0.001), however, no significant association was seen with age and gender. Conclusion: Considering high HBV infection exposure in HCWs, it is mandatory to ensure vaccination program and postvaccination evaluation along with education and safe work environment preparation.
Hepatitis B
Health Personnel
Vaccination
2014
07
01
187
192
https://ijp.iranpath.org/article_7156_a64e854025221f85f392ff4740588007.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Spectrum of Cytological Findings in Paediatric Non-Thyroidal NeckSwelling – Experience in a Tertiary Care Children Hospital
Arijit
Majumdar
Angshuman
Jana
Soumali
Biswas
Swagata
Bhattacharyya
Anirban
Jana
Background and Objective: Fine needle aspiration cytology (FNAC) is well accepted as a useful diagnostic technique in the management of adult patients with head and neck lumps. But, until recently, very few reports have been obtained regarding the role of FNAC in nonthyroidal neck masses in children. Hence, the objective of our study was to determine the diagnostic value of fine needle aspiration cytology in the diagnosis of paediatric nonthyroidalneck masses.
Methods: This descriptive study was conducted at the Department of Pathology,Dr.BCRoyPGIPSKolkata from January2012 to December 2012. Hundred patients with non-thyroidal neck masses fulfilling theinclusion criteria were included in the study. Fine needle aspirations were performed by Leishman-Giemsa staining.
Results: The most common nonneoplastic neck swelling seen in children were an enlarged lymph node due to inflammation 38(42.2%),i.e., reactive lymphadenitis. Others were TB lymphadenitis25(27.8%), nonTB granulomatous lymphadenitis 2(2.22%), chr.sialadenitis 2(2.22%), branchial cyst 4(4.44%) and epidermal cyst 3(3.33%) cases.
Overall sensitivity, specificity, positive predictive value and negative predictive value of FNAC in our cases are 93.06%, 72.22%, 93.06% and 72.22%.
Conclusion:FNA is a valuable diagnostic tool in the management of children with the clinical presentation of a suspicious neck mass. The technique reduces the need for more invasive and costly procedures like open biopsy.
Fine needle aspiration
Cytology
Neck
Tumor
2014
07
01
193
198
https://ijp.iranpath.org/article_7157_5f61fedb12f7d43969391319dcbc89d8.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Prevalence of TEM and SHV Genes in Clinical Isolates of Klebsiella Pneumonia From Mashhad, North- East Iran
Nafiseh
Izadi
Mahboubeh
Naderi Nasab
Elnaz
Harifi Mood
Zahra
Meshkat
Background & Objectives:Extended-spectrum-B-lactamase (ESBL)-producing strains of Klebsiella Pneumoniaare an important cause of many serious infections in hospitalized and nonhospitalized patients and delayed treatment of these infections in crease chance of death in patients. This study was performed to determine the prevalence of ESBL-producing K. Pneumonia and to evaluate the frequency of TEM and SHV genes among the clinical samples. Methods:One hundred and thirty isolates of K. Pneumoniawere collected at Imam Reza Hospital in Mashhad (Iran) from May 2011 to July 2012. ESBL production was determined by the double disk diffusion (DDs) test. PCR method was used to detect TEM and SHV genes. Results:Of 130 patients withK. pneumoniainfection 28 were out-patients and 102 hospitalized patients. The most specimens was urine samples (n=25 in out-patients, n=39 in hospitalized patients, totally 49.2%) followed by wound samples (n=3 in out-patients, n=21 in hospitalized patients, totally 21.5%), blood samples (n=19 in hospitalized, 14.6%). The prevalence of ESBL producingK. pnemoniaewas estimated 43% (n=56) including three of ESBLs positive isolates from out-patients and 53 from hospitalized patients. Of 56 ESBLs positive isolates, 44(87.54%) TEM, 39(69.64%) SHV and in 27 cases (48.21%) both TEM and SHV were detected. Conclusion:A high prevalence of ESBL-producing K. Pneumoniaamong the hospital isolates obtained of urinary followed by blood and wound samples were documented. The majority of them carried both TEM and SHV genes. Results of this study alarm for the physicians because treatment and control nosocomial infections for them were difficult.
Extended-spectrum B-lactamases
Klebsiella pneumonia
Cephalosporin
2014
07
01
199
205
https://ijp.iranpath.org/article_7691_1c6faa6fa37a829f1701192ef627e645.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Comparison of Polymerase Chain Reaction, Ziehl-Neelsen Staining and Histopathologic Findings in Formalin-fixed, Paraffin-Embedded Tissue Specimens for Diagnosis of Tuberculosis
Sedigheh
Khazaei
Babak
Izadi
Zhaleh
Zandieh
Azadeh
Alvandimanesh
Siavash
Vaziri
Background and Objective: Tuberculosis is still a major health problem, involving about 1/3 of the world´s population. Diagnosis is difficult when we only use Ziehl-Neelson staining. Many cases may be missed. A more rapid and sensitive diagnostic method is necessary. PCR may be helpful. The aim of this study was to compare PCR, Zieh-Neelsen staining and histopathologic findings in diagnosis of tuberculosis on formalin-fixed paraffin-embedded tissues. Methods: Paraffin blocks of the submitted specimens of the patients clinically suspicious for tuberculosis or containing granuloma were selected. Ziehl-Neelsen Staining & TB-PCR (IS6110 element) was carried out. The results of the tests were compared by using the McNemar test. Statistical significance was accepted when the P value was less than 0.05. Results: Forty five specimens were included in the study, 35 had granulomas (19 with caseous necrosis). Acid-fast bacilli were identified in 17 specimens (37.8%). TB-PCR was positive in 16specimens (84%) with caseating granulomatous, 11 specimens (68.8%) with non-caseating granulomas & 6 specimens (60%) without granulomas. (P value = 0.59). Conclusions: TB-PCR on paraffin–embedded tissue is a potentially useful approach for early, rapid and sensitive diagnosis of tuberculosis. It is especially useful when granuloma is seen in tissue section, while acid-fast stain is negative. If there was no facilities for PCR, histopathological diagnosis with clinical correlation are more reliable in comparison to AFB results.
PCR
Staining
pathology
tuberculosis
2014
07
01
206
212
https://ijp.iranpath.org/article_7692_7dbe09893fb6f3aad736c6bfa6894ecd.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Primary Malignant Melanoma of the Gastrointestinal Tract: Report of Two Cases
Akbar
Safaei
Seyed
Masood Tabib
Mohamad Reza
Farzaneh
Jahanbanoo
Shahryari
Mohamad
Bahmaniar
Although gastrointestinal involvement by metastatic malignant melanoma is common but primary gastrointestinal (GI) melanoma has been reported in rare cases. In this study we report two cases of primary gastrointestinal malignant melanoma that one of them is a known case of neurofibromatosis type 1(NF1). Both cases showed no evidence of any lesions in skin and eye. Malignant melanoma of GI tract in patient with neurofibroma is reported with hypothesis of a possible relation between two pathologies. Both primary GI melanoma and combination of NF1 with primary GI melanoma are rare entities discussed in this article.
Melanoma
Gastrointestinal tract
Neurofibromatosis
2014
07
01
213
218
https://ijp.iranpath.org/article_7693_a994ca3ec891dff447c801ecfe3970b9.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Heterotopic Pancreas- an Unusual Cause of Ileoileal Intussusception: a Case Report
Subrata
Pal
Biplab Kumar
Biswas
Sanjay
Sengupta
Srabani
Chakrabarti
Heterotopic pancreas is an uncommon developmental anomaly of upper gastrointestinal tract. Heterotopic pancreas tissue is very rarely found in ileum. Intussusception in children is usually idiopathic, but definitive aetiology can be established in 90% of adult cases. We are reporting a case of pancreatic heterotopia presenting as a lead point of ileo-ileal intussusception in a 1year 3month year old boy.
Heterotopic Tissue
Pancreas
Ileum
Intussusception
2014
07
01
219
222
https://ijp.iranpath.org/article_7694_76111ed1badaf69de14776b18219a95f.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Large Lipoma in the Floor of the Mouth: a Case Report and Review of the Literature
Maedeh
Salehi
Mina
Motallebnejad
Ramin
Forooghi
Anahita
Gorbani
Sepideh
Siadati
Lipomais a most common benign neoplasm of mature adipose tissue in trunk and extremities. The oral cavity rarely affected by this neoplasm(1-4%) and more occurs in buccal mucosa. Floor of the mouth is rarely affected. Usually its size is less than 3 cm. The present report shows an unusual case of large lipoma (5.5 cm in greatest dimension) in the floor of the mouth of a 68- year- old male and review of the literature.
Lipoma
oral cavity
Case Report
2014
07
01
223
226
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Bilateral Orbital Metastasis of Follicular Thyroid Carcinoma: a Rare Case Report
Farahnaz
Bidari-Zerehpoosh
Guive
Sharifi
Sara
Zahedifard
Hussein
Soleimantabar
Kaveh
Ebrahimzadeh
Arezoo
Aghakhani
Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer after papillary carcinoma. It usually grows slowly and is clinically indolent; but rarely, its aggressive forms with distant metastases can occur. We report here an uncommon case of bilateral orbital metastasis of FTC. A 70-year-old woman presented with bilateral exophtalmus and past medical history of thyroid nodule surgery 15 years ago. Radiologic evaluation showed massive bilateral orbital mass with extension to calvarium. Tumor decompressed and removed with the suction and curettage and the patient was treated with chemoradiotherapy after operation. Pathologic examination showed metastatic follicular thyroid carcinoma. Although orbital metastasis of follicular thyroid carcinoma is uncommon, FTC should be considered as a potential primary neoplasm in a patient with orbital mass
Follicular Thyroid Carcinoma
Orbit
Neoplasm
Metastasis
2014
07
01
229
233
https://ijp.iranpath.org/article_7696_dde358d5787c92265af3cc2abb400411.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
Needle Core Biopsy Should Replace Fine Needle Aspiration Cytology in Breast Lesions Diagnosis
Teresa
Pusiol
Maria
Grazia Zorzi
Doriana
Morichetti
Beniamino
Brancato
Michele
Scialpi
2014
07
01
234
235
https://ijp.iranpath.org/article_7697_af1bd354deed2724c5439b079205300b.pdf
Iranian Journal of Pathology
Iran J Pathol
1735-5303
1735-5303
2014
9
3
AccucheckInform II: About Its Accuracy and Precision
Beuy
Joob
Viroj
Wiwanitkit
2014
07
01
236
236
https://ijp.iranpath.org/article_7698_cd2554ae021248be115b5e8198f80178.pdf