TY - JOUR ID - 9055 TI - Frequency And Identification Of Fungal Strains In Patients With Chronic Rhinosinusitis JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Aghakhani, Arezoo AU - Eslamifar, Ali AU - Abyaneh, Mehdi Razzaghi AU - Vazir-Nezami, Mohsen AU - Moghadasi, Habibollah AU - Ramezani, Amitis AU - Shams-Ghahfarokhi, Masoomeh AU - Khameneh, Ali AU - Shokrgozar, Mohammad Ali AU - Amir-Zargar, Ali Akbar AU - Deljoodokht, Zahra AD - Dept. of Clinical Research, Pasteur Institute of Iran, Tehran, Iran. AD - Dept. of Mycology, Pasteur Institute of Iran, Tehran, Iran. AD - Dept. of ENT, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Dept. of Clinical Research, Pasteur Institute of Iran, Tehran, Iran AD - Dept. of Mycology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran AD - Dept. of Microbiology, Lahijan Azad University, Lahijan, Iran AD - Dept. of National Cell Bank, Pasteur Institute of Iran, Tehran, Iran. AD - Dept. of Immunology, Tehran University of Medical Sciences, Tehran, Iran. Y1 - 2008 PY - 2008 VL - 3 IS - 3 SP - 135 EP - 149 KW - chronic KW - Rhinitis KW - Sinusitis KW - fungi DO - N2 -   Background and Objective: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. In the past decades, there has been an increase in fungal infections of sinuses and fungal rhinosinusitis (FRS) has been diagnosed more frequently. Knowing the fungal flora and its prevalence in CRS patients will allow a better understanding of this disease, permitting a correct diagnosis, treatment and formulating its prognosis. This study was performed to assess the fungal flora and its prevalence in CRS patients. Materials and Methods: In this prospective study fungal cultures were obtained from nasal and paranasal sinuses mucus of 100 patients suffering from CRS and 40 controls who did not show any evidence of CRS .In addition, in CRS patients, paranasal sinuses mucus and tissue were histologically investigated for evidence of eosinophilic granulocytes and fungal elements besides fungal culture. Results: Fungal cultures of nasal mucus were positive in 62.5% and 60% of cases and controls respectively. Positive fungal cultures of paranasal sinuses mucus were seen in 49% of cases and 5% of controls. Aspergillus was the most frequent, followed by Penicilium and Cladosporium in both nasal and paranasal sinuses mucus culture. Eosinophilic mucin was found in 90% of CRS patients. Conclusion: Our data showed that fungal infection is frequent in patients with chronic rhinosinusitis. Based on our results, Aspergillus was the most frequent isolated fungus in CRS patients.   UR - https://ijp.iranpath.org/article_9055.html L1 - https://ijp.iranpath.org/article_9055_43c2dcdf83a4f060dce7723d814f42ef.pdf ER -