TY - JOUR ID - 8982 TI - Is “Basal-like” Carcinoma of the Breast a Distinct Clinicopathologic Entity? A Critical Review with Cautionary Notes JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Moinfar, Farid AD - Unit of Breast and Gynecologic Pathology, Department of Pathology, Medical University of Graz, Austria Y1 - 2007 PY - 2007 VL - 2 IS - 4 SP - 127 EP - 143 KW - Breast cancer KW - Basal-like carcinoma KW - Microarray Analysis KW - Molecular KW - Classification Tumors KW - Immunohistochemistry DO - N2 - This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma recently known as “basal-like” carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results, and statistical analysis. It concludes that “basal-like” carcinomas do not reflect a single, biologically uniform group of breast cancers and show significant variations in their phenotypes, grades, immunoprofiles, and clinical behavior, just as a wide range of subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Welldesigned studies with comparison of low grade non-basal versus low grade basal and high grade non-basal versus high grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathologic entity.   UR - https://ijp.iranpath.org/article_8982.html L1 - https://ijp.iranpath.org/article_8982_48f81aa2e3db44f616f49cbdcaf94e1f.pdf ER -