TY - JOUR ID - 8966 TI - Cervicovaginal Cytopathology by Liquiprep™ a New Liquid Based Method in Comparison with Conventional Pap smear JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Khaniki, Mahmood AU - Nazary, Zeynab AU - Zendehdel, Kazem AU - Fakur, Fereshte AD - Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran AD - Dept. of Gynecology, Mazandaran University of Medical Sciences, Tehran, Iran AD - Dept. of Epidemiology, Karolinska University, Stockholm, Sweden AD - Dept. of Gynecology, Gilan University of Medical Sciences, Rasht, Iran Y1 - 2009 PY - 2009 VL - 4 IS - 2 SP - 59 EP - 64 KW - Cervix Uteri KW - Cytology KW - Cervical Pap Smear KW - Liquiprep KW - Screening DO - N2 -   Background and Objective: The aim of this study was to compare the screening performance of a new modified liquid-based cytology method (Liquiprep™) with conventional PAP smear (CP) in a low risk population, using colposcopy followed by histology as “gold standard”. Patients and Methods:  This cross-sectional study was performed on random referred specimens to a general gynecological clinic in Tehran, during 20 months by a split-sample method. In both CP and Liquiprep™ group, all positive and 10% of negative results of smears were followed by colposcopy. A biopsy was taken whenever any atypical transformation zone seen. Sensitivity, specificity, negative and positive predictive values (PV), and overall accuracy of both methods were analyzed in relation to histology. Results: A total of 1265 patients were analyzed by two methods. In 158 (12.5%) of cases histological diagnosis was made. Liquiprep™ samples (94.7%) were more adequate than CP (92.1%). There was not any low or high-grade squamous intraepithelial lesion (SIL). Atypical squamous cell of undetermined significance (ASC_US) was diagnosed more with CP than with Liquiprep™ (1.43% vs. 0.79%) while pathologically 60% of ASC_US in Liquiprep™ and 16.6% in CP had degrees of SIL. The Liquiprep™ had a significantly higher sensitivity (83% vs. 66%) and positive PV (83% vs. 33%) than the CP to detect SIL at histology but the difference in specificity was non significant (98% vs. 86%). Conclusions: This study confirms the superiority of the Liquiprep™ method to detect cervical lesions in a low risk population.   UR - https://ijp.iranpath.org/article_8966.html L1 - https://ijp.iranpath.org/article_8966_898596fb96bee22104f62e7f0e1be08c.pdf ER -