TY - JOUR ID - 8544 TI - C3 and C4 Complement Levels in Iron Deficiency Anemia JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Keramati, Mohammad Reza AU - Sadeghian, Mohammad Hadi AU - Ayatollahi, Hossein AU - Rafatpanah, Houshang AU - Khajeh Daluei, Mohammad AU - Baesi, Nafise AD - Neonatal Research Center, Mashhad, Iran AD - Dept. of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran AD - Dept. of Immunology, Immunology research center, Mashhad, Iran AD - Dept. of Social Medicine, Mashhad, Iran Y1 - 2011 PY - 2011 VL - 6 IS - 2 SP - 56 EP - 62 KW - Iron Deficiency Anemia KW - C3 Complement KW - C4 Complement DO - N2 - Background and Objectives: Complement proteins are some of the most important plasma proteins of the innate immune system. Impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. This study was conducted to show whether serum C3 and C4 complement change in adult nonpregnant female with iron deficient anemia or not. Methods: Forty five normal subjects and 45 iron deficient anemia (hypochrom microcytic) cases were entered in this case and control study by using patients’ clinical history and also results of CBC, Serum ferritin, iron and total iron binding capacity. Serum C3, and C4 were measured in case and control subjects with nephlometry method, finally comparison between result of patients group and control group was done with using suitable statistical test. Results: Mean serum C3 and C4 in patient group was 1.28 ± 0.81 and 0.28 ± 0.23 g/L respectively and for control group was 1.39 ± 0.87 and 0.35 ± 0.25 g/L respectively. Although serum complements were slightly lower in patient groups in compared to control group but this differences was not meaningful with t test. Conclusion: This study showed serum C3 and C4 complements levels were not changed in iron deficiency anemia. UR - https://ijp.iranpath.org/article_8544.html L1 - https://ijp.iranpath.org/article_8544_2e7d7dce9904ea4d8ca090e25dbacd0a.pdf ER -