TY - JOUR ID - 8354 TI - Seroprevalence of IgG Antibodies against Bordetella pertussis in Different Age Groups in Tehran, Iran JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Eslamifar, Ali AU - Ramezani, Amitis AU - Banifazl, Mohammad AU - Khadem-Sadegh, Akbar AU - Aghakhani, Arezoo AD - Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran AD - Iranian Society for Support of Patients with Infectious Diseases, Tehran, Iran Y1 - 2012 PY - 2012 VL - 7 IS - 3 SP - 171 EP - 176 KW - Bordetella pertussis KW - Seroepidemiology KW - Iran DO - N2 - Background and Aims: Pertussis is a highly contagious, vaccine-preventable disease. Determination of the seroepidemiology of pertussis makes possible the evaluation of pertussis immunity in a population. In this study, we determined the seroprevalence of Bordetella pertussis IgG antibodies in different age groups in Tehran, Iran. Materials and Methods: Overall, 1101 subjects between ages of 8 months and 20 years were tested for the presence of pertussis toxin (PT), filamentous hemagglutinin (FHA) and different lipopolysaccharides (LPS) antibodies by ELISA. Results: The overall prevalence of pertussis antibodies was 48% and the mean antibody level was 44± 47.7 U/ml. Over half (53.1%) of the children aged 8 months to 6 years were negative for pertussis antibodies. Pertussis antibodies rates and levels were significantly different between age groups (P < 0.001) and their significant elevations were observed with increasing age. Conclusion: Up to half of the vaccinated children lacked an antibody response to vaccine, so using a more immunogenically effective vaccine to ensure sufficient immunity is essential. We showed that B. pertussis infection is on the rise in Iranian adolescents and young adults. Booster vaccination of this age group appears to be the most logical approach to disease prevention in adolescents and control the circulation of the organism.   UR - https://ijp.iranpath.org/article_8354.html L1 - https://ijp.iranpath.org/article_8354_88a1a0ebac8c49e9a6ca70d14a135491.pdf ER -