TY - JOUR ID - 38309 TI - Epithelial-Myoepithelial Carcinoma of the Palate: Report of a Case and Review of the Literatures JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Mahdavi, Nazanin AU - Ghorbanpour, Maedeh AD - Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Y1 - 2020 PY - 2020 VL - 15 IS - 2 SP - 144 EP - 150 KW - Epithelial-myoepithelial carcinoma KW - salivary gland tumor KW - Clear cell tumors KW - Head and Neck KW - oral mucosa DO - 10.30699/ijp.2020.105039.2076 N2 - Epithelial-myoepithelial carcinoma (EMC) is considered as a rare malignant salivary gland neoplasm with good prognosis, low recurrence rate and rare metastasis. Here we present a case of epithelial-myoepithelial carcinoma in a 42-year-old female with a swelling of 3-year duration in her palate. Histopathologic evaluation of the lesion demonstrated a well-circumscribed, biphasic salivary gland tumor composed of double-layered ductal/glandular structures, composed of small luminal eosinophilic cells and abluminal larger clear myoepithelial cells, and luminal cells were positive for pan-cytokeratin, while the abluminal cells exhibited strong immunoreactivity for p63. Ki-67 proliferative index was 1% in abluminal cells. In this article, histopathologic and immunohistochemical features of EMC and its mimics are discussed and the previously reported cases of EMC in the literature are summarized. UR - https://ijp.iranpath.org/article_38309.html L1 - https://ijp.iranpath.org/article_38309_4316467a411839ac2c92fe893e58bf92.pdf ER -