TY - JOUR ID - 37616 TI - The Insulin-like Growth Factor-1 (G>A) and 5,10-methylenetetrahydrofolate Reductase (C677T) Gene Variants and the Serum Levels of Insulin-like Growth Factor-1, Insulin, and Homeostasis Model Assessment in Patients with Acne Vulgaris JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Zinati-Saeed, Sakineh AU - Shakiba, Ebrahim AU - Rahimi, Ziba AU - Akbari, Mona AU - Najafi, Fariba AU - Bahrehmand, Fariborz AU - Vaisi-Raygani, Asad AU - Rahimi, Zohreh AU - Ebrahimi, Ali AU - Rahimi, Mehrali AD - Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran AD - Medical Biology Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran AD - Department of Dermatology, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran AD - Fertility and Infertility Research Center, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran AD - Department of Internal Medicine, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran Y1 - 2020 PY - 2020 VL - 15 IS - 1 SP - 23 EP - 29 KW - Acne vulgaris KW - Methylenetetrahydrofolate reductase KW - Insulin-like growth factor-1 KW - Insulin KW - Homeostasis model assessment DO - 10.30699/ijp.2019.105695.2098 N2 - Background & Objective:To find an association between gene variants of insulin-like growth factor-1 (IGF-1) and 5,10-methylenetetrahydrofolate reductase (MTHFR) with the risk of acne vulgaris (AV).Methods:In a case-control study, we investigated 150 AV patients and 148 healthy individuals (aged 18-25 years) for the IGF-1 G>A and MTHFR C677T polymorphisms, as well as the serum levels of IGF-1, insulin, and the homeostasis model assessment of insulin resistance (HOMA-IR). The serum biochemical parameters and the genotypes of IGF-1 G>A and MTHFR C677T were detected by using appropriate kits and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods, respectively.Results:The frequencies of IGF-1 and the MTHFR polymorphisms were not significantly different comparing patients and controls. The serum level of IGF-1 was 179.8±72.8 µg/L in AV patients compared to 164.6±63.7 µg/L in controls (P=0.056). The serum level of insulin in female patients was significantly higher than controls. The HOMA was 3.54±5.6 in patients compared to 1.16±1.4 (P<0.001) in controls. Significantly higher levels of fasting blood sugar (FBS), total cholesterol, and low-density lipoprotein-cholesterol (LDL-C) were detected in female patients than controls. However, the level of estradiol was significantly lower in female patients than in controls. In females, the presence of the MTHFR T allele was associated with significantly higher levels of FBS and LDL-C, as well as a significantly lower level of estradiol compared to those carriers of the C allele.Conclusion:We found the absence of an association between IGF-1 and MTHFR polymorphisms with the risk of AV. However, increased insulin, IGF-1, and HOMA levels in AV patients indicated the effect of insulin and insulin resistance in the risk of AV and its severity. UR - https://ijp.iranpath.org/article_37616.html L1 - https://ijp.iranpath.org/article_37616_f4b6725a5f2ca9290f029e96b394f607.pdf ER -