TY - JOUR ID - 31842 TI - Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Puri, Arun AU - Wadhwa, Heena AU - Singh, Navtej AD - Baba Farid University of Health Sciences, Faridkot, India Y1 - 2018 PY - 2018 VL - 13 IS - 2 SP - 281 EP - 284 KW - Non Secretory KW - Multiple Myeloma DO - 10.30699/ijp.13.2.281 N2 - Multiple Myeloma is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells. It is characterized by a clinical  pentad of 1) anemia, 2) a monoclonal protein in the serum or the urine or both, 3) bone leisons and or bone pain, 4) hypercalcemia >11.5g/dl and 5) renal insufficiency. Non secretory multiple myeloma is a rare variant of the classic form of multiple myeloma and accounts for 1% to 5 % of all cases of multiple myeloma. The clinical presentation and radiographic findings of non-secretory multiple myeloma and multiple myeloma are the same. The diagnosis of multiple myeloma requires the demonstration of monoclonal gammopathy in the serum or urine. In non-secretory multiple myeloma, however no such gammopathy can be demonstrated, making the diagnosis more difficult. We describe a 60 year old woman who initially presented with back pain which when further investigated by complete blood count revealed hemoglobin of 13g/dl, Total Leukocyte Count  of 10,890 and platelet count of 1.5 lac/cmm. Viral markers revealed HCV positive. Hypercalcemia with a serum calcium level of 12.5g/dl was also demonstrated. MRI revealed multiple lytic bony lesions. No monoclonal gammopathy was found in the serum or urine and bone marrow biopsy showed marked plasmacytosis of > 45%. We present a case of Non Secretory multiple myeloma because of its illusive nature and rare entity. UR - https://ijp.iranpath.org/article_31842.html L1 - https://ijp.iranpath.org/article_31842_d74c8f1ce43b24d90c31affefbaf9579.pdf ER -