TY - JOUR ID - 245649 TI - MIF and MMP-9 Serum Changes in Type II Diabetes and Non-Diabetic Subjects: A Short Communication JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Rastgoo Haghi, Alireza AU - Khorami, Nasrin AU - Fotoohi, Mahtab AU - Moradi, Abbas AD - Department of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Y1 - 2021 PY - 2021 VL - 16 IS - 4 SP - 444 EP - 447 KW - Diabetes Type 2 KW - HbA1c KW - MIF KW - MMP-9 DO - 10.30699/ijp.2021.131429.2456 N2 - Background & Objective: Diabetes is a metabolic disease and is associated with failure of various organs. Macrophage migration factor (MIF) and matrix metalloproteinase (MMP-9) are two of the most important factors in the pathogenesis of diabetes.Methods: In this descriptive-analytical study, 30 patients with type 2 diabetes mellitus from Hamadan Diabetes Center were selected by convenience sampling. Moreover, 30 healthy first-degree relatives and 30 unrelated non-diabetics, were examined for MMF and MMP-9 and their variations based on age, gender, body mass index (BMI) and hemoglobin A1C.Results & Conclusion: The mean and standard deviation of MIF in diabetic patients, and relatives and non-relatives of diabetic patients were 592.87±78.19, 131.82±88.27 and 94.63±23.88, respectively (P<0.001). The mean and standard deviation of the MMP-9 in diabetic patients, and relatives and non-relatives of diabetic patients were 2570.64±2220.03, 918.57±650.08 and 629.09±288.32, respectively (P<0.001). MIF and MMP-9 did not have a significant relationship with age, sex, duration of disease and BMI. However, we observed a direct and significant correlation between hemoglobin A1C and the level of MIF and MMP-9 (P<0.001). In patients with type 2 diabetes, serum levels of MMP-9 and MIF, consistent with HbA1c, increase with no significant association with age, sex, BMI and duration of diabetes.  UR - https://ijp.iranpath.org/article_245649.html L1 - https://ijp.iranpath.org/article_245649_da8043dd1cafe9eda69ac73abd76116c.pdf ER -