TY - JOUR ID - 239969 TI - CD137: A Member of the TNFR Family - in Psoriasis Skin Lesions in Comparison with Normal Skin Specimens JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Rajabi, Parvin AU - Eftekhari, Syed Mehdi AU - Kadkhodaii, Azadeh AU - Kefayat, Amirhosein AD - Department of Pathology, Faculty of Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran Y1 - 2021 PY - 2021 VL - 16 IS - 2 SP - 103 EP - 108 KW - CD137 KW - Psoriasis KW - T cell KW - TNF-alpha KW - Tumor necrosis factor receptor DO - 10.30699/ijp.2020.118767.2290 N2 - Background and Objective: CD137 is a member of the TNF-Receptor family. TNF-alpha antagonists have therapeutic effect in active psoriasis. In this study, the relative frequency of CD137 expression was investigated in the inflammatory cells of psoriasis lesions for the first time. Methods: The specimens were obtained from pathology department of Al-Zahra hospital from 2007 to 2016, from paraffin-embedded skin biopsies. A number of 64 psoriasis skin lesions specimens and 34 normal skin specimens were rechecked for the diagnosis. Then, the immunohistochemical staining for CD137, CD4, and CD8 was performed. Results: CD137 expression of dermal inflammatory cells in psoriasis lesion was 11.19±5.5%. Although, in normal skin biopsied, CD137 expression was observed in 1.3±3.03% of the inflammatory cells. (p =0.001). The relative frequency of the CD137 positive inflammatory cells was significantly more in epidermis versus dermis (epidermis: 31.1%±12.8, dermis 11.1%±5.5). There was no remarkable relation between the CD137 expression rate and the CD4: CD8 ratio. Conclusion: CD137 as a TNF-alpha receptor has a significant role in pathogenesis of the psoriasis lesions. Therefore, CD137 antagonists can be considered as a novel target for the treatment of incurable psoriasis patients. UR - https://ijp.iranpath.org/article_239969.html L1 - https://ijp.iranpath.org/article_239969_905c99c6ae6c84a553c8e534f3cc019f.pdf ER -