Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Cutaneous Metaplastic Synovial Cyst: A Case Report
423
426
EN
Mina
Majdi
Dept. of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran, Iran
majdimina@yahoo.com
Hana
Saffar
Dept. of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran, Iran
hana.saffar@yahoo.com
Alireza
Ghanadan
Dept. of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran, Iran
ghannadan@sina.tums.ac.ir
Cutaneous metaplastic synovial cyst (CMSC), presents as a solitary, tender subcutaneous nodule that usually occurs at the site of previous surgery or trauma. Histologically, the lesion is characterized by a cystic structure with villous-like projections that lined by metaplastic synovial tissue. The main cause remains unclear, but trauma is presumed to be a precipitating factor, as most reported cases have a history of antecedent cutaneous injury. Here we present a case of CMSC in a 51 yr old man, presented with a painless deep-seated dermal nodule in the medial aspect of left ankle without history of any trauma or surgery in this site. Immuno-histochemistry study reveals positive reaction for CD68 in the cystic wall and negative reactions for S-100. CMSC is a unique lesion and worthy to attention, and should be included in the differential diagnosis of deep dermal cutaneous cysts.
Metaplastic Synovial Cyst,Immunohistochemistry,Synovial Cyst
https://ijp.iranpath.org/article_23771.html
https://ijp.iranpath.org/article_23771_afc417a2689951b5d29e05f8c134dd31.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Isolated Hepatic Tuberculoma – A Case Report
427
430
EN
Biplab
Biswas
Department of Pathology, Bankura Sammilani Medical College, West Bengal, India
drbiplabkrbiswas@yahoo.co.in
Subrata
Pal
Department of Pathology, College of Medicine and Sagore Dutta Hospital, West Bengal, India
subratapal1985@gmail.com
DhrubaJyoti
Moulick
Department of Pathology, College of Medicine and Sagore Dutta Hospital, West Bengal, India
dhrubajyotimoulik@gmail.com
Mrinal
Sikdar
Department of Pathology, Kolkata National Medical College, West Bengal, India
mrinalsikdar@gmail.com
Isolated hepatic tuberculoma is localized hepatic tuberculosis (TB) without bile duct involvement, which presents as solitary or multiple nodular mass lesion of liver mimicking a neoplastic lesion in radiological evaluation. Clinical presentation and biochemical tests for liver functions show non-specific abnormality, which is not helpful for diagnosis. As the treatment, modality of isolated hepatic tuberculoma is anti-tubercular drugs. Prognosis is very good in comparison to other differential diagnoses. We are presenting such a rare case of isolated hepatic tuberculoma from tribal area of Bankura district, West Bengal, India in a 38-yr female patient presenting as fever, abdominal pain and solitary nodular lesion on radiological evaluation . Even different imaging modalities cannot make accurate diagnosis of isolated hepatic tuberculoma where simple biopsy and histopathology of the lesion can confirm the diagnosis.
Hepatic Tuberculoma,Nodular Mass Lesion,India
https://ijp.iranpath.org/article_23218.html
https://ijp.iranpath.org/article_23218_3884e9bc743f1ad651cb458b7b1496c4.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
A Bizarre Presentation of Osteoid Osteoma of Maxilla
431
434
EN
Tanya
Khaitan
Dept. of Dentistry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India
tanyakhaitan@gmail.com
Pachigolla
Ramaswamy
Dept. of Oral Medicine & Radiology, St. Joseph Dental College & Hospital, Eluru, Andhra Pradesh, India
drpramaswamy@rediffmail.com
Uday
Ginjupally
Dept. of Oral Medicine & Radiology, Kamineni Institute of Dental Sciences, Narketpally Andhra Pradesh, India of dental sciences
uday2361@gmail.com
Arpita
Kabiraj
Dept. of Oral Pathology & Microbiology, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India
arpita.kabiraj82@gmail.com
Osteoid osteoma (OO) is a benign osteogenic lesion that is extremely rare in jaws. It is characterized by proliferation of either cancellous or compact bone and can be central, peripheral or extraskeletal. Pain is a distinctive feature of this lesion accompanied by vasomotor disturbances, which occur long before radiographic and histopathology findings manifest. Here, we present a rare case report of OO of maxilla in a 40-yr-old male patient with noteworthy clinical, radiological and histological presentation. The diagnosis of OO is usually obtained by radiographs confirmed by histopathological analysis. Thus, the oral physician should have keen observation and appropriate knowledge concerning the same to avoid confusion with similar bony lesions.
bone,Genesis,Neoplasm,Nidus
https://ijp.iranpath.org/article_23910.html
https://ijp.iranpath.org/article_23910_9c62dba2641321f8d9b1d3b6799c0d55.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Odontogenic Fibroma of the Maxilla - An Atypical Presentation
435
438
EN
Arpita
Kabiraj
Dept. of Oral Pathology & Microbiology, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India
arpita.kabiraj82@gmail.com
Anil
Singh
Dept. of Oral Pathology & Microbiology, Saraswati Dental College, Lucknow, U.P, India
dranilsingh@yahoo.com
Tanya
Khaitan
Dept. of Dentistry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India
tanyakhaitan@gmail.com
Amrita
Jaiswal
Dept. of Prosthodontics, Sardar Patel Post Graduate Institute of Dental & Medical Sciences, Lucknow, U.P, India
rohitjaiswal75@rediffmail.com
Odontogenic fibroma (OF) is considered an unusual, benign mesenchymal neoplasm and one of the most little-understood lesions amongst all odontogenic neoplasms. The incidence rate of the tumor is from 0% to 5.5%. WHO classified them into intraosseous or central and extraosseous or peripheral variants. It chiefly consists of fibroblastic tissue with an inconsistent amount of inactive appearing odontogenic epithelium. The lesion has a slow growth along with cortical expansion with equal predilection in the anterior maxilla and posterior mandible. Radiologically, multilocular radiolucency is the most frequent finding with few cases being associated with root resorption or displacement. Microscopically, mature collagen fibers and numerous fibroblasts along with odontogenic epithelial islands are characteristically found. Central Odontogenic Fibroma responds well to surgical enucleation with no tendency for malignancy or recurrence. Here we report a rare case report of an 18 yr old male patient with Odontogenic fibroma of the posterior maxilla.
Mesenchyme,Neoplasm,Odontogenic Fibroma,Odontogenic Epithelium
https://ijp.iranpath.org/article_23219.html
https://ijp.iranpath.org/article_23219_d27d85f3c4e90a874d5507ea0b5360bb.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Jaw Pain as a First Presentation in the Diagnosis of Breast Cancer
439
442
EN
Payam
Azadeh
0000-0003-1771-7377
Dept. of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
azadehpayam@gmail.com
Nasser
Rakhashni
Dept. of Pathology, GILDRC, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
n_rakhshani@yahoo.com
Ali
Yaghobi Joybari
0000-0003-2658-7746
Dept. of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
dryaghobii@yahoo.com
Pegah
Gorji Bayani
Dept. of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
p.g.bayani@gmail.com
Samaneh
Sarbaz
Dept. of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
sarbaz.samaneh@gmail.com
Maryam
Farasatinasab
Dept. of Clinical Pharmacy, School of Pharmacy-International Campus, FCRDC, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
maryfarasati@gmail.com
The oral cavity is uncommon site for metastatic disease usually discovered secondary to malignancy. We encountered with a rare case in which metastasis to mandibular bone was the first clinical sign in the diagnosis of breast cancer without any radiographic findings. A 49-yr-old premenopausal woman, was referred to the Department of Medical Oncology of Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2014, presented with pain and tenderness in the left mandibular and temporal bone and paresthesia of the lower left lip and chin. CT scan of mandible showed no significant finding. Four months later, she was referred with complaints left breast pain for 4 wk and worsening swelling, pain and paresthesia. Breast examination revealed a 2 cm firm nodule on the left breast. Based on her medical history and histopathological study, metastatic carcinoma of the breast was suspected. She has received chemoradiotherapy that led to complete relief of her symptoms and remission of the disease. In the presence of an ambiguous sign in oral cavity such as jaw pain or paresthesia, diagnostic examination of malignancy is recommended.
Breast cancer,Jaw Pain,Mandibular Metastasis
https://ijp.iranpath.org/article_23220.html
https://ijp.iranpath.org/article_23220_873b532282a37b09a81753d5bec51c35.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Disseminated Skeletal Angiomatosis Initially Misdiagnosed As Metastatic Tumor: A Case Report
443
447
EN
Fariba
Binesh
0000-0002-6917-3028
Dept. of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
binesh44@yahoo.com
Kazem
Aghili
Dept. of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
aghilikazem@yahoo.com
Marjan
Hakiminia
Dept. of Internal medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
hakiminia_m@yahoo.com
Mohammad Reza
Vahidfar
Dept. of Internal medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
vahidfar@yahoo.com
Roghayeh
Masumi
Blood and Cancer Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
dr.masumi@yahoo.com
Disseminated angiomatosis, also referred to as cystic angiomatosis, is a generalized disease that involves bones and soft tissue. It is characterized by multifocal hemangiomatous lesions of the bones with possible visceral organ involvement. The clinical manifestations differ according to the site and the extension of disorder. Here we describe a case of generalized angiomatosis occurring in a 35-yr-old Iranian woman, initially misdiagnosed as osseous metastasis, who presented at Shahid Sadoughi Hospital, Yazd, Iran in February 2014. Although the clinical, radiological and pathological features are diagnostic, the process is often mistaken with other lytic lesions of the bones, especially malignant tumors. The case is being reported owing to its scarcity as per the literature published globally.
Angiomatosis,Disseminated,Skeletal,Misdiagnosis
https://ijp.iranpath.org/article_23385.html
https://ijp.iranpath.org/article_23385_787f0d924a7ac4505f2ed0ff798d017a.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Primary Localized Vesical Amyloidosis Mimicking Bladder Carcinoma: A Case Report
448
451
EN
Purwa
Patil
Department of Pathology Grant Govt Medical College, Mumbai, India
bushan.warpe@gmail.com
Bhushan
Warpe
Department of Pathology Grant Govt Medical College, Mumbai, India
bhushan.warpe@gmail.com
Amyloidosis of urinary bladder is a rare condition and may be primary or secondary in nature. A case of primary localized vesical amyloidosis (VA) in a 40-yr-old man is described confused with neoplasm by cystoscopic, urographic. Surgical specimens obtained by transurethral resection (TUR) were diagnostic and histologically revealed amyloid deposits in sub-epithelial stroma with chronic inflammatory and giant-cell reaction. Congo-red positivity of the deposit was retained even after pre-treatment with KMnO4, confirming AL protein and primary nature of the amyloidosis.
Vesical Amyloidosis (VA),Urinary bladder,Congo red
https://ijp.iranpath.org/article_23221.html
https://ijp.iranpath.org/article_23221_bca3f36db6cc7f22c19cba397f99e07a.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Russell Body Gastritis: an Unusually Presentation of the Chronic Gastritis
452
455
EN
Betul
PEKER CENGIZ
Department of Pathology Yunus Emre State Hospital, Eskisehir, TURKEY
betip76@yahoo.com
Fatma
Secil KIRDOK
Department of Gastroenterology, Yunus Emre State Hospital, Eskisehir, TURKEY
secilkirdok@yahoo.com
Hayrettin
DIZEN
Department of Surgery, Yunus Emre State Hospital, Eskisehir, TURKEY
hayrettindizen@gmail.com
Russell body gastritis is a rare form of chronic gastritis. It is characterized by the invasion of lamina propria by plasma cells that included eosinophilic cytoplasmic inclusion. In the literature, most of the cases are associated with Helicobacter pylori. Russell body gastritis and Helicobacter pylori infection are generally seen together incidentally. We report here two cases of Russell body gastritis with <em>Helicobacter</em> <em>pylori</em> infection in a 51-yr-old woman and a 39-yr-old man from <em>Eskisehir, Turkey.</em>
Russell Body,Gastritis,Helicobacter pylori
https://ijp.iranpath.org/article_23772.html
https://ijp.iranpath.org/article_23772_c1f051f995efa928a5cef7590b97e059.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Prominent Cold Nodule in Multinodular Goiter Revealed to Be Thyrolipoma: A Case Report
456
459
EN
Maryam
Kadivar
000-0003-3121-6747
Dept. of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
dmkadivar@gmail.com
Parnian
Kheirkhah Rahimabad
School of Medicine, Iran University of Medical Sciences, Tehran, Iran
parniankheirkhah@gmail.com
Sareh
Salarinejad
Dept. of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
shelman3206000@yahoo.com
The presence of adipose tissue in the thyroid gland is a rare finding. Thyrolipoma or adenolipoma of the thyroid is a benign, encapsulated lesion of the thyroid composed of variable amounts of fat and glandular elements. This report presents a case of thyrolipoma in a 69-yr-old female presenting with neck swelling and respiratory distress. Differential diagnosis of the fat-containing thyroid lesion is also presented. Differentiation of the condition from similar lesions is necessary for accurate diagnosis of thyrolipoma.
Thyrolipoma,Thyroid gland,Adenolipoma,Histopathology
https://ijp.iranpath.org/article_23222.html
https://ijp.iranpath.org/article_23222_854c8a4072c9ae96d4efa949da0f0e68.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Middle Ear Salivary Gland Choristoma: A Case Report
461
464
EN
Katayoun
Ziari
Dept. of Pathology, AJA University of Medical Sciences, Tehran, Iran
drk_ziari@yahoo.com
Kamyab
Alizadeh
Dept. of Pathology, AJA University of Medical Sciences, Tehran, Iran
kamyab_alizadeh@yahoo.com
Salivary gland choristoma of the middle ear cavity is a very rare condition. These lesions are a result of a defective embryonic development and their adjacent structures may be associated with abnormalities. Here we report a case of salivary gland choristoma of the middle ear who presented to Be’sat Hospital, Tehran, Iran in 2015 with unilateral conductive hearing loss. There are 41 case reports in English and non-English literature from 1961. Taylor and Martin reported the first case of middle ear salivary choristoma.
Salivary Gland,Choristoma,Middle ear
https://ijp.iranpath.org/article_23223.html
https://ijp.iranpath.org/article_23223_745b8b265cf23437caeb2259597de869.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
A Case of Bone Angiosarcoma
465
468
EN
Mahmood
Akhavan Tafti
Dept. of Surgery, Shahid Sadooghi Hospital, Shahid Sadooghi University of Medical Sciences, Yazd, Iran
akhavanmahmood@yahoo.com
Najmeh
Jafari
0000-0002-9026-6157
Dept. of Pathology, Shahid Sadooghi Hospital, Shahid Sadooghi University of Medical Sciences, Yazd, Iran
jafarynajmeh@yahoo.com
Jalil
Zare
Dept. of Surgery, Shahid Sadooghi Hospital, Shahid Sadooghi University of Medical Sciences, Yazd, Iran
zarejalil@yahoo.com
Mohamad
Jalal Jafari
Dept. of Surgery, Shahid Sadooghi Hospital, Shahid Sadooghi University of Medical Sciences, Yazd, Iran
jafarymohamad@yahoo.com
Primary angiosarcoma of bone is very rare.It occurs more commonly in middle-age and later life, with a male predominance in the ratio of 2:1. Angiosarcoma of bone has a tendency to involve the long tubular bones, and multifocal involvement is common. Here, we present a case of a 69-yr-old man in Shahid Sadooghi Hospital of Yazd in 2014 that had angiosarcoma of the left tibia. He was treated with curettage and bone fixation. Two months after the surgery, he died of pulmonary metastasis.
angiosarcoma,bone,vascular tumor
https://ijp.iranpath.org/article_23911.html
https://ijp.iranpath.org/article_23911_abfedf2d5da37140ac71f1619447a07a.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Primary Stromal Sarcoma of Breast: A Rare Entity
469
473
EN
Sanjay
Kumar
Dept. of Pathology, PGIMS, Rohtak (Haryana), India
drsharma1212@gmail.com
Jyoti
Sharma
Dept. of Pathology, PGIMS, Rohtak (Haryana), India
drjyoti1212@yahoo.in
Megha
Ralli
Dept. of Pathology, PGIMS, Rohtak (Haryana), India
drmegharalli@gmail.com
Gurpreet
Singh
Dept. of Pathology, PGIMS, Rohtak (Haryana), India
megharalli_86@yahoo.co.in
Sonu
Kalyan
Department of Pathology
Pt BDS PGIMS Rohtak
dockalyan23@gmail.com
Rajeev
Sen
Dept. of Pathology, PGIMS, Rohtak (Haryana), India
drrajeevsen@gmail.com
Primary soft tissue sarcomas of the breast constitute less than 5% of all soft tissue sarcomas and less than 1% of malignant breast cancers. The rarity of this tumor limits most studies to small retrospective case reviews and case reports. Primary breast sarcomas are locally aggressive tumors as evidenced by the high rate of local recurrence when excisional surgery is performed. A contemporary multidisciplinary approach to therapy including surgery, radiation, and chemotherapy is advocated. Herein, we report a case of 45-yr-old female, who presented with a large ulcerated breast mass and was diagnosed as carcinoma breast on fine needle aspiration. Modified radical masectomy was performed and was diagonsed with primary breast stromal sarcoma on histopathology, which is a rare entity.
Breast,Histopathology,Sarcoma
https://ijp.iranpath.org/article_23773.html
https://ijp.iranpath.org/article_23773_f92ac1fc2c43e69f760b55a17ed86905.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Orbital Metastasis from Rectal Adenocarcinoma- Report of a Rare Case
474
477
EN
Subrata
Pal
Dept. of Pathology, College of Medicine and SagoreDutta Hospital, India
subratapal1985@gmail.com
Kingshuk
Bose
Dept. of Pathology, BankuraSammilani Medical College, India
kingshukbose@gmail.com
Abhishek
Sharma
Dept. of Pathology, College of Medicine and SagoreDutta Hospital, India
drabhisheksharma@gmail.com
Mrinal
Sikder
Dept of Pathology, Kolkata National Medical College, India
mrinalsikder@gmail.com
Colorectal carcinoma is a common malignancy in India as well as in world. Inspite of its high metastasizing ability to various organs and lymph node, orbital metastasis is exceptional. Very few cases have been reported in the world literature. We report orbital metastasis in a case of moderately differentiated rectal adenocarcinoma in a 58-year male patient from India in 2015. We want to focus on the rare metastatic pathway of rectal adenocarcinoma and early diagnosis of the orbital metastasis, which can help in application of therapy to save the eyesight.
Orbital Metastasis,Adenocarcinoma,Rectum
https://ijp.iranpath.org/article_23242.html
https://ijp.iranpath.org/article_23242_e714cded9bfbb3f43702320e28534775.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
11
5
2016
10
01
Bilateral Ovarian Clear Cell Carcinoma Arising in 17 Year Longstanding History of Bilateral Ovarian Endometriosis
478
482
EN
Thin Thin
Win
Dept. of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
drthinthinwin@gmail.com
Nik Mohamed Zaki
Nik Mahmood
Dept. of Obstetrics and Gynaecology, School of Medical Sciences, Universiti Sains Malaysia,, 16150 Kubang Kerian, Kelantan, Malaysia
nmzaki@usm.my
Saung Oo
Ma
Dept. of Obstetrics and Gynaecology, School of Medical Sciences, Universiti Sains Malaysia,, 16150 Kubang Kerian, Kelantan, Malaysia
masaung@upm.edu.my
Mazita
Ismail
Dept. of Pathology, Hospital Raja Permaisuri Bainun, 30990 Ipoh, Perak, Malaysia
mazitai@yahoo.com
Clear cell carcinoma of ovary is uncommon ovarian tumour that arises from surface epithelium of ovary. It has well-known association with ovarian endometriosis. We report here the first case of bilateral clear cell carcinoma of ovaries in a 40-year-old woman with a 17-year history of bilateral ovarian endometriosis. In addition, during the longstanding duration of the endometriosis, the patient was treated with hormonal therapy, including oestrogen. It represents the first report of such bilateral involvement in the background of ovarian endometriosis. This should prompt clinicians to be aware that prolonged hormonal treatment of endometriosis may precipitate bilateral malignancy of the ovary.
Clear Cell Carcinoma,Ovarian Endometriosis,Malignant Transformation
https://ijp.iranpath.org/article_23224.html
https://ijp.iranpath.org/article_23224_7ac3e346c75d5d3f77288338fe173064.pdf