Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2
4
2007
09
01
Is “Basal-like” Carcinoma of the Breast a Distinct Clinicopathologic Entity? A Critical Review with Cautionary Notes
127
143
EN
Farid
Moinfar
Unit of Breast and Gynecologic Pathology, Department of Pathology, Medical University of Graz, Austria
farid.moinfar@meduni-graz.at
<span id="ctl00_ContentPlaceHolder1_DataList1_ctl00_AbstractLabel">This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma recently known as “basal-like” carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results, and statistical analysis. It concludes that “basal-like” carcinomas do not reflect a single, biologically uniform group of breast cancers and show significant variations in their phenotypes, grades, immunoprofiles, and clinical behavior, just as a wide range of subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Welldesigned studies with comparison of low grade non-basal versus low grade basal and high grade non-basal versus high grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathologic entity.</span>
Breast cancer,Basal-like carcinoma,Microarray Analysis,Molecular,Classification Tumors,Immunohistochemistry
https://ijp.iranpath.org/article_8982.html
https://ijp.iranpath.org/article_8982_48f81aa2e3db44f616f49cbdcaf94e1f.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2
4
2007
09
01
Antimicrobial Susceptibility Pattern of Clinical Isolates of Pseudomonas Aeruginosa in a Pediatric Hospital
144
148
EN
Sara
Jam
Iranian Research Center for HIV/AIDS, Tehran, Iran
Duman
Sabzevari
Iranian Research Center for HIV/AIDS, Tehran, Iran
duman.sabzevari@yahoo.com
Arezoo
Aghakhani
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
aaghakhani@pasteur.ac.ir
Ali
Eslamifar
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
Mohammad
Banifazl
Iranian Society for Support of Patients with Infectious Diseases, Tehran, Iran
Amitis
Ramezani
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
iiccom@iiccom.com
<span id="ctl00_ContentPlaceHolder1_DataList1_ctl00_AbstractLabel">Background and Objective: Pseudomonas aeruginosa has become a frequent cause of nosocomial infections, particularly in intensive care units (ICUs). Many reports have documented high rates of resistance in this species to commonly-used broad-spectrum antibiotics. The aim of this study was to assess the in vitro activity of some antibiotics against Pseudomonas aeruginosa strains to determine the susceptibility patterns of isolates to different antibiotics. Materials and Methods: A total of 233 Pseudomonas aeruginosa isolates obtained from various clinical specimens of hospitalized children in Ali-Asghar hospital of Tehran (Iran) were considered for susceptibility test. These strains were tested against 12 different antibiotics by a disk diffusion method. Of these isolates, 33.9% were from trachea, 31.8% from urine, 6.9% from eye, 5.2% from blood, 5.1% from ear, 1.3% from cerebrospinal fluid, 1.2% from stool, and 14.6% from other sites. In addition, 48.5% of P. aeruginosa strains were isolated from patients in ICUs. Results: The most active antimicrobials were amikacin and other active compounds were gentamicin, ceftazidime, and ciprofloxacin respectively. Isolates from ICUs were more resistant to amikacin and gentamicin as compared to those from non-ICU wards (p<0.05). Isolates from trachea were more resistant to amikacin, gentamicin, ciprofloxacin and ceftazidime than those from other sites (p<0.05). Conclusion: Our study showed that amikacin was the most active agent against P. aeruginosa followed by gentamycin, ceftazidime, and ciprofloxacin. According to our in vitro study results, active antibiotic susceptibility testing and surveillance should be continued in order to curtail the problem of antibiotic resistance. </span>
Pseudomonas aeruginosa,Antibiotic,resistance,Disk Diffusion Antimicrobial Tests
https://ijp.iranpath.org/article_8983.html
https://ijp.iranpath.org/article_8983_7893076daa27539696e1715f365f6609.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2
4
2007
09
01
Comparison between Needle Biopsy under Guide of Conventional Computerized Tomography (CCT) and Fluoroscopic Computerized Tomography (FCT) in Abdominal, Mediastinal, Lung, Pelvic, Bone, and Liver Masses
49
153
EN
Alireza
Abdollahi
0000-0002-5714-967X
Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran
dr_p_abdollahi@yahoo.com
Mitra
Mehrazma
Dept. of Pathology, Iran University of Medical Sciences, Tehran, Iran
Hossein
Ghanaati
Dept. of Radiology, Tehran University of Medical Sciences, Tehran, Iran
<span id="ctl00_ContentPlaceHolder1_DataList1_ctl00_AbstractLabel">Background and Objective: Computerized tomography and fluoroscopic computerized tomography are amongst the methods used for guiding needle biopsy processes; however, fluoroscopic computerized tomography demonstrates the images during the process of biopsy. This study aims to compare and contrast the success of biopsy under guide of computerized tomography and fluoroscopic computerized tomography, independently and based on the location of the mass. Background and Objective: Computerized tomography and fluoroscopic computerized tomography are amongst the methods used for guiding needle biopsy processes; however, fluoroscopic computerized tomography demonstrates the images during the process of biopsy. This study aims to compare and contrast the success of biopsy under guide of computerized tomography and fluoroscopic computerized tomography, independently and based on the location of the mass. Results: In this study, among 206 subjects, 122 were examined under guide of fluoroscopic tomography and 84 under guide of conventional computerized tomography. In all anatomical locations of the mass except for mediastinum, negative cases of biopsy in conventional computerized tomography were more than fluoroscopic computerized tomography the total rate of success in fluoroscopic computerized tomography group was 86.1% and in conventional computerized tomography it was 76.2%. Conclusion: The results of this study showed that the fluoroscopic computerized tomography in biopsy is more successful than conventional computerized tomography in pelvis, abdomens, bone and liver and this might be the result of the feasibility of watching the biopsy needle during the procedure.</span>
needle biopsy,Computed tomography,Fluoroscopy
https://ijp.iranpath.org/article_8984.html
https://ijp.iranpath.org/article_8984_f1f366139afa44fb96d7afa5354197b4.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2
4
2007
09
01
Metabolic Abnormalities in HIV-Positive Patients Receiving Highly Active Antiretroviral Therapy
154
158
EN
Amitis
Ramezani
Dept. of Clinical Research, Pasteur Institute of Iran, Tehran, Iran
iiccom@iiccom.com
Minoo
Mohraz
Iranian Research Center for HIV/AIDS, Tehran, Iran
Mohammad
Banifazl
Iranian Society for Support of Patients with Infectious Disease, Tehran, Iran
Latif
Gachkar
Infectious Diseases Research Center, Shaheed Beheshti Univ. Med. Sci., Tehran, Iran
Sara
Jam
Iranian Research Center for HIV/AIDS, Tehran, Iran
Ali
Eslamifar
Dept. of Clinical Research, Pasteur Institute of Iran, Tehran, Iran
Farhad
Yaghmaie
Health Deputy of Shaheed Beheshti Univ. Med. Sci., Tehran, Iran
Kambiz
Nemati
Health Center of Northern Tehran, Shaheed Beheshti Univ. Med. Sci., Tehran, Iran
Arezoo
Aghakhani
Dept. of Clinical Research, Pasteur Institute of Iran, Tehran, Iran
aaghakhani@pasteur.ac.ir
<span id="ctl00_ContentPlaceHolder1_DataList1_ctl00_AbstractLabel">Background and Objective: Dyslipidemia has become a common problem in human immunodeficiency virus (HIV) disease, especially in patients on combination antiretroviral therapy. In this study we aimed to determine the prevalence of dyslipidemia and metabolic abnormalities in 2 groups of HIV infected patients receiving highly active antiretroviral therapy (HAART) and antiretroviral-naive patients. Patients and Methods: Forty HIV infected patients treated by HAART as a case group (6 females and 34 males) with a mean age of 40.7 ± 10 years and 15 HIV naïve as a control group (2 females and 13 males) with a mean age of 38.40 ± 8.3 enrolled in this study. The two groups were well matched in respect to age, sex and CD4 cell counts. A standardized questionnaire with epidemiological, clinical, and therapeutic data was completed by physicians. Blood samples were obtained for metabolic measurements. CD4 positive cell count was measured by f lowcytometry. Results: Levels of total cholesterol, triglycerides, LDL, HDL, lactate, and FBS were elevated in 24%, 37%, 3.7%, 44.4%, 29.6% and 11% of patients respectively. There was a significant difference regarding mean total cholesterol and LDL between treated group and controls (p<0.05). There was also no significant difference between treated group and controls regarding triglyceride, HDL, lactate and FBS levels. Conclusion: Our study demonstrated that metabolic abnormalities are relatively common in HIV-infected patients receiving HAART. Therefore, it is recommended to screen the HIV infected patients on HAART for metabolic disorders, potential of morbidity, and possible long-term cardiovascular risk factors.</span>
Dyslipidemia,Hyperglycemia,HIV,Highly active antiretroviral therapy
https://ijp.iranpath.org/article_8985.html
https://ijp.iranpath.org/article_8985_ee4d21133ac1eb6d5488c995e9e22d7a.pdf