Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Plasmapheresis- Review Article
167
180
EN
Alireza
Abdollahi
0000-0002-5714-967X
1. Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran
2. Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
dr_p_abdollahi@yahoo.com
Plasmapheresis, which is defined as the removal of plasma, can be either "adjusted plasma" or “exchange of plasma”. The former is defined as selective withdrawal of certain (un)-pathological plasma components in different ways such as perfusion and then returning the remained donor plasma to him, the latter is non-selective removal of all components of plasma to provide blood products for injection into patients or to be used as the input of blood transfusion refinery or to remove the pathogen contained plasma before compensating for the volume losses with an equal volume of plasma or more commonly, replacing plasma with a substitute fluid (colloid or crystalloid) such as albumin. Plasmapheresis was divided generally into two groups:
1- Plasma products by donor plasmapheresis
2- Therapeutic plasmapheresis
Therapeutic plasma exchange or TPE are often attributed to plasma that exit from the body of patient then compensated by any kind of replacement fluid volumes to support neurmolemic situation of patients. Plasmapheresis is currently used as a therapeutic modality in a wide array of conditions. Generally, plasmapheresis is used when a substance in the plasma, such as immunoglobulin, is acutely toxic and can be efficiently removed. Myriad conditions fall under this category, including neurologic, hematologic, metabolic, dermatologic, rheumatologic, and renal diseases, as well as intoxications, that can be treated with plasmapheresis.
Plasmapheresis,Exchange the Plasma
https://ijp.iranpath.org/article_7153.html
https://ijp.iranpath.org/article_7153_7e294693633b34482f2e51eca771a4a9.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Pathologic Lesions of Liver, Kidney and Lung in the Autopsy of 100 Mustard Gas-Exposed Iranian War Veterans
181
186
EN
Nahid
Kazemzadeh
Dept. of Forensic Medicine, Iran University of Medical Sciences, Tehran, Iran
Alireza
Kadkhodaei
Forensic and Legal Medicine Organization, Tehran, Iran
Babak
Soltani
Dept. of Pediatrics, Kashan University of Medical Sciences, Kashan, Iran
Siamak
Soltani
Dept. of Forensic Medicine, Iran University of Medical Sciences, Tehran, Iran
siamaksoltani92@yahoo.com
Sahar
Rismantab Sani
Dept. of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran
Background & Objectives: Respiratory, central nervous system, and skin complications of mustard gas toxicity have previously been studied; however, the liver and kidney side effects due to this intoxication have not been fully noted. We aimed to evaluate the frequency of liver, kidney and lung lesions in mustard gas-exposed Iranian veterans who had been exposed to the toxin almost 2 decades before.
Methods: A total of 100 veteran bodies underwent autopsy by at least two forensic medicine specialists. The liver, kidney and lung specimens were sent for pathological examination and their lesions, severity of the lesions, and the relation between the type/severity of the lesions and the time elapsed since their appearance were studied.
Results: A total of 83%, 63%, and 62% of the veterans had lung, liver, and kidney pathologies. The most common pathologies included liver steatosis, interstitial fibrosis of the kidney, and lung atelectasis.
Conclusion: Liver and kidney pathologies are far more common than what is considered in the mustard gas-exposed veterans. These pathologies are often accompanied by very severe lung complications.
Sulfur mustard,Autopsy,Lung,Liver,Kidney,pathology
https://ijp.iranpath.org/article_7155.html
https://ijp.iranpath.org/article_7155_7251a1e3b1ac612b51aed901d052e032.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Hepatitis B Infection: Prevalence and Response to Vaccination among Health Care Workers in Babol, Northern Iran
187
192
EN
Masomeh
Bayani
In fectious Disease and Tropical Research center, Babol University
of Medical Sciences, Babol, Iran
Sepideh
Siadati
Dept. Of Pathology, Babol University of Medical Sciences, Babol, Iran
siadati_sepideh @yahoo.com
Mahmoud
Hajiahmadi
In fectious Disease and Tropical Research center, Babol University
of Medical Sciences, Babol, Iran
Afshin
Khani
In fectious Disease and Tropical Research center, Babol University
of Medical Sciences, Babol, Iran
Navid
Naemi
In fectious Disease and Tropical Research center, Babol University
of Medical Sciences, Babol, Iran
<span id="ctl00_ContentPlaceHolder1_DataList1_ctl00_AbstractLabel" style="font-size: 10pt;">Background & Objectives: Hepatitis B is one of the major health problems in the world. Health care workers (HCWs) are at high risk of acquiring hepatitis B virus. The aim of this study was to evaluate the prevalence of HBV infection and the immune response to HBV vaccine among the HCWs in Babol, northern Iran. Methods: This study was accomplished on 527 HCWs and administrative staff working at Rohani Hospital, Babol, northern Iran from 2011 to 2012. HBs- Ag, HBc- Ab and HBs- Ab were measured by ELISA method. All susceptible staff vaccinated with recombinant hepatitis B vaccine (Pasteur Institute of Iran) and HBs - Ab titer was evaluated 3 months after the last dose. Results: Anti-HBc was positive in 32 (6.1%) and HBs-Ag in 4 (0.75%) of the participants. The HBV exposure in HCWs was four times greater than the administrative staff (6.65% vs. 1.63%). There was significant association between HBV exposure and occupation and also educational level (P < 0.001), however, this association was not found with age and gender. Seroconversion was seen in 211 (91.7%) of 230 participants who received three-dose series of hepatitis B vaccine. The seroconversion is significantly decreasing by the increase of age (P < 0.001), however, no significant association was seen with age and gender. Conclusion: Considering high HBV infection exposure in HCWs, it is mandatory to ensure vaccination program and postvaccination evaluation along with education and safe work environment preparation.</span>
Hepatitis B,Health Personnel,Vaccination
https://ijp.iranpath.org/article_7156.html
https://ijp.iranpath.org/article_7156_a64e854025221f85f392ff4740588007.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Spectrum of Cytological Findings in Paediatric Non-Thyroidal NeckSwelling – Experience in a Tertiary Care Children Hospital
193
198
EN
Arijit
Majumdar
Dept. Of Pathology, West Bengal University of Health Sciences, Kolkata, India
arijitmajumdar23@gmail.com
Angshuman
Jana
Dept. Of Microbiology, West Bengal University of Health Sciences, Kolkata, India
Soumali
Biswas
Dept. Of Anatomy, West Bengal University of Health Sciences, Kolkata, India
Swagata
Bhattacharyya
Dept. Of Pathology, West Bengal University of Health Sciences, Kolkata, India
Anirban
Jana
Dept. Of Medicine, West Bengal University of Health Sciences, Kolkata, India
Background and Objective: Fine needle aspiration cytology (FNAC) is well accepted as a useful diagnostic technique in the management of adult patients with head and neck lumps. But, until recently, very few reports have been obtained regarding the role of FNAC in nonthyroidal neck masses in children. Hence, the objective of our study was to determine the diagnostic value of fine needle aspiration cytology in the diagnosis of paediatric nonthyroidalneck masses.
Methods: This descriptive study was conducted at the Department of Pathology,Dr.BCRoyPGIPSKolkata from January2012 to December 2012. Hundred patients with non-thyroidal neck masses fulfilling theinclusion criteria were included in the study. Fine needle aspirations were performed by Leishman-Giemsa staining.
Results: The most common nonneoplastic neck swelling seen in children were an enlarged lymph node due to inflammation 38(42.2%),i.e., reactive lymphadenitis. Others were TB lymphadenitis25(27.8%), nonTB granulomatous lymphadenitis 2(2.22%), chr.sialadenitis 2(2.22%), branchial cyst 4(4.44%) and epidermal cyst 3(3.33%) cases.
Overall sensitivity, specificity, positive predictive value and negative predictive value of FNAC in our cases are 93.06%, 72.22%, 93.06% and 72.22%.
Conclusion:FNA is a valuable diagnostic tool in the management of children with the clinical presentation of a suspicious neck mass. The technique reduces the need for more invasive and costly procedures like open biopsy.
Fine needle aspiration,Cytology,Neck,Tumor
https://ijp.iranpath.org/article_7157.html
https://ijp.iranpath.org/article_7157_5f61fedb12f7d43969391319dcbc89d8.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Prevalence of TEM and SHV Genes in Clinical Isolates of Klebsiella Pneumonia From Mashhad, North- East Iran
199
205
EN
Nafiseh
Izadi
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mahboubeh
Naderi Nasab
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Elnaz
Harifi Mood
Student Research Committee (SRC), Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Zahra
Meshkat
Women’s Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
meshkatz@mums.ac.ir
Background & Objectives:Extended-spectrum-B-lactamase (ESBL)-producing strains of Klebsiella Pneumoniaare an important cause of many serious infections in hospitalized and nonhospitalized patients and delayed treatment of these infections in crease chance of death in patients. This study was performed to determine the prevalence of ESBL-producing K. Pneumonia and to evaluate the frequency of TEM and SHV genes among the clinical samples. Methods:One hundred and thirty isolates of K. Pneumoniawere collected at Imam Reza Hospital in Mashhad (Iran) from May 2011 to July 2012. ESBL production was determined by the double disk diffusion (DDs) test. PCR method was used to detect TEM and SHV genes. Results:Of 130 patients withK. pneumoniainfection 28 were out-patients and 102 hospitalized patients. The most specimens was urine samples (n=25 in out-patients, n=39 in hospitalized patients, totally 49.2%) followed by wound samples (n=3 in out-patients, n=21 in hospitalized patients, totally 21.5%), blood samples (n=19 in hospitalized, 14.6%). The prevalence of ESBL producingK. pnemoniaewas estimated 43% (n=56) including three of ESBLs positive isolates from out-patients and 53 from hospitalized patients. Of 56 ESBLs positive isolates, 44(87.54%) TEM, 39(69.64%) SHV and in 27 cases (48.21%) both TEM and SHV were detected. Conclusion:A high prevalence of ESBL-producing K. Pneumoniaamong the hospital isolates obtained of urinary followed by blood and wound samples were documented. The majority of them carried both TEM and SHV genes. Results of this study alarm for the physicians because treatment and control nosocomial infections for them were difficult.
Extended-spectrum B-lactamases,Klebsiella pneumonia,Cephalosporin
https://ijp.iranpath.org/article_7691.html
https://ijp.iranpath.org/article_7691_1c6faa6fa37a829f1701192ef627e645.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Comparison of Polymerase Chain Reaction, Ziehl-Neelsen Staining and Histopathologic Findings in Formalin-fixed, Paraffin-Embedded Tissue Specimens for Diagnosis of Tuberculosis
206
212
EN
Sedigheh
Khazaei
Molecular Pathology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
skhazaei2003@ yahoo.com
Babak
Izadi
Molecular Pathology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
bizadi@hotmail.com
Zhaleh
Zandieh
Molecular Pathology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Azadeh
Alvandimanesh
Molecular Pathology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Siavash
Vaziri
Molecular Pathology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Background and Objective: Tuberculosis is still a major health problem, involving about 1/3 of the world´s population. Diagnosis is difficult when we only use Ziehl-Neelson staining. Many cases may be missed. A more rapid and sensitive diagnostic method is necessary. PCR may be helpful. The aim of this study was to compare PCR, Zieh-Neelsen staining and histopathologic findings in diagnosis of tuberculosis on formalin-fixed paraffin-embedded tissues. Methods: Paraffin blocks of the submitted specimens of the patients clinically suspicious for tuberculosis or containing granuloma were selected. Ziehl-Neelsen Staining & TB-PCR (IS6110 element) was carried out. The results of the tests were compared by using the McNemar test. Statistical significance was accepted when the P value was less than 0.05. Results: Forty five specimens were included in the study, 35 had granulomas (19 with caseous necrosis). Acid-fast bacilli were identified in 17 specimens (37.8%). TB-PCR was positive in 16specimens (84%) with caseating granulomatous, 11 specimens (68.8%) with non-caseating granulomas & 6 specimens (60%) without granulomas. (P value = 0.59). Conclusions: TB-PCR on paraffin–embedded tissue is a potentially useful approach for early, rapid and sensitive diagnosis of tuberculosis. It is especially useful when granuloma is seen in tissue section, while acid-fast stain is negative. If there was no facilities for PCR, histopathological diagnosis with clinical correlation are more reliable in comparison to AFB results.
PCR,Staining,pathology,tuberculosis
https://ijp.iranpath.org/article_7692.html
https://ijp.iranpath.org/article_7692_7dbe09893fb6f3aad736c6bfa6894ecd.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Primary Malignant Melanoma of the Gastrointestinal Tract: Report of Two Cases
213
218
EN
Akbar
Safaei
Dept. of Pathology, Molecular Pathology and Cytogenetic Ward, Shiraz University of Medical Sciences, Shiraz, Iran
Seyed
Masood Tabib
Internal ward, Boushehr University of Medical Sciences, Boushehr, Iran
Mohamad Reza
Farzaneh
Dept. of Pathology, Molecular Pathology and Cytogenetic Ward, Shiraz University of Medical Sciences, Shiraz, Iran
mrfarzaneh@yahoo.com
Jahanbanoo
Shahryari
Dept. of Pathology, Molecular Pathology and Cytogenetic Ward, Shiraz University o Medical Sciences, Shiraz, Iran
Mohamad
Bahmaniar
Dept. of Pathology, Fatemeh Zahra Hospital, Boushehr University of Medical Sciences, Boushehr, Iran.
Although gastrointestinal involvement by metastatic malignant melanoma is common but primary gastrointestinal (GI) melanoma has been reported in rare cases. In this study we report two cases of primary gastrointestinal malignant melanoma that one of them is a known case of neurofibromatosis type 1(NF1). Both cases showed no evidence of any lesions in skin and eye. Malignant melanoma of GI tract in patient with neurofibroma is reported with hypothesis of a possible relation between two pathologies. Both primary GI melanoma and combination of NF1 with primary GI melanoma are rare entities discussed in this article.
Melanoma,Gastrointestinal tract,Neurofibromatosis
https://ijp.iranpath.org/article_7693.html
https://ijp.iranpath.org/article_7693_a994ca3ec891dff447c801ecfe3970b9.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Heterotopic Pancreas- an Unusual Cause of Ileoileal Intussusception: a Case Report
219
222
EN
Subrata
Pal
Dept. of Pathology, Bankura Sammilani Medical Callage, Bankura, India
subratapal1985@gmail.com
Biplab Kumar
Biswas
Dept. of Pathology, West Bengal University of Health Sciences, Bankura, India
Sanjay
Sengupta
Dept. of Pathology, Bankura Sammilani Medical Callage, Bankura, India
Srabani
Chakrabarti
Dept. of Pathology, Bankura Sammilani Medical Callage, Bankura, India
Heterotopic pancreas is an uncommon developmental anomaly of upper gastrointestinal tract. Heterotopic pancreas tissue is very rarely found in ileum. Intussusception in children is usually idiopathic, but definitive aetiology can be established in 90% of adult cases. We are reporting a case of pancreatic heterotopia presenting as a lead point of ileo-ileal intussusception in a 1year 3month year old boy.
Heterotopic Tissue,Pancreas,Ileum,Intussusception
https://ijp.iranpath.org/article_7694.html
https://ijp.iranpath.org/article_7694_76111ed1badaf69de14776b18219a95f.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Large Lipoma in the Floor of the Mouth: a Case Report and Review of the Literature
223
226
EN
Maedeh
Salehi
Dept. of Oral Medicine, Scool of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
Mina
Motallebnejad
Cellular and Molecular Biology research Center, Babol University of Medical Sciences, Babol, Iran
Ramin
Forooghi
Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Babol University of Medical Sciences, Babol, Iran
Anahita
Gorbani
Dept. of Oral, Medicine Babol University of Medical Sciences, Babol , Iran
Sepideh
Siadati
Dept. of Pathology, Babol University of Medical Sciences, Babol , Iran
siadati_sepideh@yahoo.com
Lipomais a most common benign neoplasm of mature adipose tissue in trunk and extremities. The oral cavity rarely affected by this neoplasm(1-4%) and more occurs in buccal mucosa. Floor of the mouth is rarely affected. Usually its size is less than 3 cm. The present report shows an unusual case of large lipoma (5.5 cm in greatest dimension) in the floor of the mouth of a 68- year- old male and review of the literature.
Lipoma,oral cavity,Case Report
https://ijp.iranpath.org/article_7695.html
https://ijp.iranpath.org/article_7695_d41d8cd98f00b204e9800998ecf8427e.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Bilateral Orbital Metastasis of Follicular Thyroid Carcinoma: a Rare Case Report
229
233
EN
Farahnaz
Bidari-Zerehpoosh
Dept. of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Guive
Sharifi
Dept. of Neurosurgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sara
Zahedifard
Dept. of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hussein
Soleimantabar
Dept. of Radiology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Kaveh
Ebrahimzadeh
Dept. of Neurosurgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Arezoo
Aghakhani
Dept. of Clinical Research, Pasteur Institute of Iran, Tehran, Iran
araghakhani@hotmail.com
<span id="ctl00_ContentPlaceHolder1_DataList1_ctl00_AbstractLabel">Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer after papillary carcinoma. It usually grows slowly and is clinically indolent; but rarely, its aggressive forms with distant metastases can occur. We report here an uncommon case of bilateral orbital metastasis of FTC. A 70-year-old woman presented with bilateral exophtalmus and past medical history of thyroid nodule surgery 15 years ago. Radiologic evaluation showed massive bilateral orbital mass with extension to calvarium. Tumor decompressed and removed with the suction and curettage and the patient was treated with chemoradiotherapy after operation. Pathologic examination showed metastatic follicular thyroid carcinoma. Although orbital metastasis of follicular thyroid carcinoma is uncommon, FTC should be considered as a potential primary neoplasm in a patient with orbital mass</span>
Follicular Thyroid Carcinoma,Orbit,Neoplasm,Metastasis
https://ijp.iranpath.org/article_7696.html
https://ijp.iranpath.org/article_7696_dde358d5787c92265af3cc2abb400411.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
Needle Core Biopsy Should Replace Fine Needle Aspiration Cytology in Breast Lesions Diagnosis
234
235
EN
Teresa
Pusiol
Institute of Anatomic Pathology, S.Maria del Carmine Hospital Rovereto – Rovereto , Italy
teresa.pusiol@apss.tn.it
Maria
Grazia Zorzi
Institute of Anatomic Pathology, S.Maria del Carmine Hospital Rovereto – Rovereto , Italy
Doriana
Morichetti
Institute of Anatomic Pathology, S.Maria del Carmine Hospital Rovereto – Rovereto , Italy
Beniamino
Brancato
Institute for the Study and Prevention of Cancer , Florence, Italy
Michele
Scialpi
Radiological and Odontostomatological Sciences, Complex Structure of Radiology, Perugia University, S, Maria della Misericordia Hospital, S, Andrea delle Fratte, 06134 Perugia, Italy
https://ijp.iranpath.org/article_7697.html
https://ijp.iranpath.org/article_7697_af1bd354deed2724c5439b079205300b.pdf
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
9
3
2014
07
01
AccucheckInform II: About Its Accuracy and Precision
236
236
EN
Beuy
Joob
Sanitation Medical Academic Center, Bangkok, Thailand
beuyjoob@hotmail.com
Viroj
Wiwanitkit
Faculty of Medicine, University of Nis, Nis , Serbia
https://ijp.iranpath.org/article_7698.html
https://ijp.iranpath.org/article_7698_cd2554ae021248be115b5e8198f80178.pdf