ORIGINAL_ARTICLE
Comparison of 5FU-base Chemoradiation with and without Eloxatin on Pathologic Complete Response in Neoadjuvant Chemoradiation of Rectal cancer
Background and Objectives: To compare pathologic complete response (pCR) in patients with advanced rectal cancer receiving neoadjuvant chemoradiotherapy (NACT) by 5-FU or Xeloda (capecitabine) with and without Eloxatin (oxaloplatin injection).
Materials and Methods: Seventy-five consecutive patients with the diagnosis of advanced rectal adenocarcinoma were included. Two basic chemotherapy regimens were used: one drug (5-FU or Xeloda) or two-drug (5-U or Xeloda with Eloxatin). Endpoints were pCR and preservation of sphincter during surgery through low anterior resection (LAR). All analyses were done using SPSS software version 17.0 (SPSS Inc., Chicago, IL).
Results: There were no significant differences between the group of patients who received one-drug regimen with those who received two-drug regimen regarding the pCR (four cases (23.5%) versus 25 vases (43.1%)) state or the type of surgery performed [nine cases (52.9%) versus 36 cases (62.1%)].
Conclusion: Adding Eloxatin to the standard treatment of rectal adenocarcinoma (5-FU based) did not yield in a higher pCR or a higher chance to preserve the anal sphincter.
https://ijp.iranpath.org/article_8534_28067e82b193ac5cc4a012334cf18c28.pdf
2011-06-01
110
116
Eloxatin
5FU
Rectum
Adenocarcinoma
Ali
Yaghoubi
dryaghobi@yahoo.com
1
Dept. of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Payam
Azadeh
azadehpayam@gmail.com
2
Dept. of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
KhosroM
M Sheibani
3
Dept. of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Mohammad
Foudazi
4
Dept. of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Behrouz
Shafaghi
5
Dept. of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Manouchehr
Davaei
6
Dept. of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
ORIGINAL_ARTICLE
The Relationship between Size of Adenocarcinoma of Colon and Lymph Node Involvement
Background and Objectives: Involvement of lymph nodes is an important prognostic factor in the most cancers, including colorectal cancer. In the recent years, invasion to blood and lymphatic vessels has been shown to predict involvement of lymph nodes and the number of involved nodes has been less studied issue. The aim of this study was determination of the relationship between the size of colorectal adenocarcinoma and lymph node involvement. Materials & Methods: In this cross-sectional study, 116 patients were enrolled with colorectal cancer from Rasoul-e-Akram and Mehr Hospitals in 2002-2008. Data analysis was performed by SPSS-15 software. Results were expressed as frequency, percent, and mean ±SD. We used Chi2, student t-test and correlation tests for statistical analysis. Results: 54.3% of patients were male and 45.7% were female. Mean age of them was 59.4± 12.9 years. Mean of tumor size (longest diameter) was 5.4± 2.2 (range: 1.5 to 12) cm. Mean number of involved lymph nodes was 4.9± 3.5(range: 1-14). There was no correlation between number of lymph node involvement and tumor size. There was no correlation between lymph node involvement and tumor and age group, sex, location and depth of tumor. Poorly differentiated tumor significantly correlated to lymph node involvement (P=0.001). Conclusion: There is no correlation between tumor size and number of involved lymph node in colorectal cancer. However, poor histopathologic grade is associated with lymph node involvement.
https://ijp.iranpath.org/article_8537_3dbd1f6b71384e76eb6e8eda8d01e6b1.pdf
2011-06-01
117
123
Adenocarcinoma
Colon
Tumor Burden
Lymphatic Metastases
Nasser
Rakhshani
n_rakhshani@yahoo.com
1
Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Roshanak
Derakhshandeh
2
Dept. of Hematology& Oncology, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Seyed Amir
Mirbagheri
3
Dept of Gastroenterology , Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Farhad
Zamani
4
Gastrointestinal and Liver Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Ahad
Atef Vahid
5
Deptof Surgery, Mehr Hospital, Tehran,Iran
AUTHOR
Mitra
Mehrazma
6
Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
ORIGINAL_ARTICLE
Comparison of the Results of Fine Needle Aspiration Biopsy Specimens and Permanent Histopathologic Preparation in Orbital Mass Lesions
Background and Objectives: We aimed at evaluating the efficacy of fine needle aspiration biopsy (FNA) in comparison with histopathology and demonstrating whether cytological study could be a proper diagnostic tool in orbital mass lesions. Materials and Methods: In a cross sectional study during 36 months, patients referred to our ophthalmologic center affiliated to Tehran University of Medical Sciences, for evaluation of orbital masses, were selected for FNA. After the surgery, the results of FNA were compared against histopathologic diagnoses as our gold standard method. Finally, the frequencies of specimen adequacy, the accuracy of FNA in distinguishing benign and malignant lesions and in the exact definitive diagnosis of the disorders were reported. Results: In 27.4% of the total 62 cases, the specimens were inadequate for cytologic evaluations. The rate of specimen adequacy in malignant and benign lesions was 82.6 % and 66.66%, respectively. From the morphologic point of view, the rate of the exact definitive diagnosis of malignant and benign disorders in the total 62 cases was 78.2% and 38.46% and; in the adequate specimens, it was 94.73% and 57.69%, respectively. There was no false positive FNA result for malignant cells and only in one malignant case, the FNA report was falsely negative. All data wee analyzed by SPSS software and p value Conclusion: FNA was considered more beneficial in the diagnosis of malignant lesions. FNA is a relatively noninvasive, rapid, specific, and accurate method for the preoperative primary diagnosis of orbital mass lesions and especially in malignant lesions and in some conditions, specific diagnoses can be achieved.
https://ijp.iranpath.org/article_8538_8a0d7532a035932d18973750cf30dee6.pdf
2011-06-01
124
132
Fine needle aspiration
Orbits
Tumor
Histopathology
Fahimeh
Asadi Amoli
path1383@yahoo.com
1
Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Ali
Sadeghi Tarri
2
Eye Research Center, TehranUniversity of Medical Sciences, Tehran, Iran
AUTHOR
Khalil
Hamzeh Doost
3
Eye Research Center, TehranUniversity of Medical Sciences, Tehran, Iran
AUTHOR
Naser
Kamalian
4
Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Hedieh
Moradi Tabriz
hmoradi@razi.tums.ac.ir
5
Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Correlation between the Level of Creatinine, Serum Cardiac Troponines and Left Ventricle Function Tests in Patients with Chronic Renal Diseases without Acute Coronary Syndrome
Background and Objectives: The aim of this study was to survey the relationship between the level of creatinine,cardiac troponins serum and the function of the left ventricle in patients with kidney insufficiency,without acute coronary syndrome. Materialsand Methods:The sample was150 patients with nondialysis chronic kidney disease without acute coronary syndrome, hospitalized at Imam Khomeini Center through 2008-2009. All the patients had serum creatinine (cr) 1.5mgor greater and no symptoms of acute coronary syndrome in the first month. Serum Cr and troponin T and I were measured in blood samples and patients left ventricular function (LVEF) were estimated by echocardiography. Then based on the objectives, the findings were analyzed with SPSS soft ware. Results:Serum troponin T levels were significantly higher in patients with greater Cr levels but there was no significant relationship between troponin I and Cr levels. Patients with greater degrees of LV dysfunction had significantly upper levels of troponin T(P=0.0001). In this category, patients with diabetes, old age, cigarette smokers, greater levels of Cr, advanced stages of chronic kidney disease and greater degrees of LV dysfunction showedsignificantly higher levels of troponin T(P=0.0001). Conclusion:To identify chronic kidney disease patients at increased risk for cardiovascular events, serum troponin T can be used. In high-riskpatients, the evaluation for cardiovascular diseases could be done earlier in the course of chronic kidney disease.
https://ijp.iranpath.org/article_8540_85793b140e972a7071ab978bc972a757.pdf
2011-06-01
133
138
Creatinine
Troponin-T
Troponin-I
Left Ventricular Dysfunction
Chronic Renal
Failure
Amir
Farhang Zand-Parsa
1
Dept. of Cardiology, Imam Khomeini Hospitals Complex, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mahsa
Sedaghati-Hagh
2
Dept. of Cardiology, Imam Khomeini Hospitals Complex, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mitra
Mahdavi-Mazdeh
3
Dept. of Nephrology, Imam Khomeini Hospitals Complex, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Alireza
Abdollahi
dr_p_abdollahi@yahoo.com
4
Dept. of Pathology, Imam Khomeini Hospitals Complex, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Group B Streptococcal Sepsis in a Newborn: a Case Report
Newborns’ bacterial infections due to group B Streptococcus (GBS) happen in two forms including early-onset disease or late-onset disease. In this paper, we report a case of early-onset GBS infection in a male infant. A 22-year-old primigravid woman delivers a term normal looking male infant. Nasal flaring, grunting, and poor feeding presented soon after birth. An empiric treatment with intravenous ampicillin and amikacin initiated. On the second day, he was transferred to Newborn Intensive Care Unit (NICU). The intravenous antibiotics were changed to tazocin and vancomycin in NICU. The blood culture (BC) was positive for GBS. After 48 hours, respiratory distress symptoms disappeared, BC was negative, and ABG and CBC became normal. Finally, the infant was discharged after 15 days.GBS is a normal flora of women's gastrointestinal and genitourinary tracts. Infants with early-onset GBS sepsis need very close observation including repeated vital signs evaluation.
https://ijp.iranpath.org/article_8542_3cb1cd6c401dce96eaab55c0c70f8d1b.pdf
2011-06-01
139
142
Group B Streptococcal
Sepsis
Newborn
Alireza
Abdollahi
dr_p_abdollahi@yahoo.com
1
Dept. Of Pathology, School of Medicine, TehranUniversityof Medical Sciences, Tehran,Iran
AUTHOR
Hedieh
Moradi-Tabriz
hmoradi@razi.tums.ac.ir
2
Dept. Of Pathology, School of Medicine, TehranUniversityof Medical Sciences, Tehran,Iran
LEAD_AUTHOR
Baharak
Mehdipour Aghabagher
3
Dept. Of Pathology, School of Medicine, TehranUniversityof Medical Sciences, Tehran,Iran
AUTHOR
ORIGINAL_ARTICLE
Breast Metastasis of Ovarian Carcinoma
Breast metastasis of ovarian carcinoma is rare. To date, only 39 cases have been reported in the English-language literature so far. We are herewith reporting a primary ovarian papillary serous cyst adenocarcinoma metastasing to breast and epsilateral supraclavicular node in a 58 year old female as the first case in our centre, located at North-East India. The purpose of reporting this case is to emphasize the need of examining breasts in patients of ovarian cancer and the need to exercise meticulous care to exclude second primary at breast from possible secondaries at breast from ovarian can cer.
https://ijp.iranpath.org/article_8543_34529ad13a6d784bc8eb59c940dffb0c.pdf
2011-06-01
143
146
Breast
Metastasis
Ovary Cancer
Dhaneshor
Sharma
1
Dept. of Radiotherapy, Regional Institute of Medical Sciences, Lamphelpat, Imphal, India
AUTHOR
Tomcha
Singh
2
Dept. of Radiotherapy, Regional Institute of Medical Sciences, Lamphelpat, Imphal, India
AUTHOR
Rajesh
Singh Laishram
rajeshlaishr@gmail.com
3
Dept. of Pathology, Regional Institute of Medical Sciences, Lamphelpat, Imphal, India
LEAD_AUTHOR
Ranjit
Singh
4
Dept.of Obstetrics & Gyanecology, Regional Institute of Medical Sciences, Lamphelpat, Imphal, India
AUTHOR
ORIGINAL_ARTICLE
Primitive Neuroectodermal Tumor (PNET) ofKidney -A Rare Entity
Primitive neuroectodermal tumor (PNET) of kidney is an extremely rare renal neoplasm with only about fifty reported cases in literature. Presumably,of neural crest origin, these tumors behave aggressively and carry a poor prognosis. We report a case of 22-year old female patient complaining of left loin pain with recurrent hematuria for last 3 months. On clinical examination, the abdomen was soft and no palpable mass was felt. She underwent ultrasonography and com puted tomography, which revealed a left renal mass. A left radical nephrectomy was performed. Histopathological examination of the nephrectomy specimen showed features of primitive neu roectodermal tumor arising from left kidney, which was confirmed by immunohistochemistry (IHC). The patient was treated with post-nephrectomy chemotherapy and was symptom-free at six-month follow-up.
https://ijp.iranpath.org/article_8545_b29e2495d0108fc1190984bc0e78147a.pdf
2011-06-01
147
152
Primitive Neuroectodermal Tumor
Kidney
Indranil
Chakrabarti
dr.inch@yahoo.co.in
1
Dept. of Pathology, North Bengal Medical College, Siliguri, India
LEAD_AUTHOR
Anuradha
De
2
Dept. of Pathology, North Bengal Medical College, Siliguri, India
AUTHOR
Amita
Giri
3
Dept. of Pathology, North Bengal Medical College, Siliguri, India
AUTHOR
ORIGINAL_ARTICLE
Giant Cell Glioblastoma -A Rare Pediatric Cerebral Neoplasm
Giant cell glioblastoma is an extremely rare variant of Glioblastoma (WHO grade IV) which is characterized by a predominance of bizarre, multinucleated giant cells. These tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. In pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. Here, we report a case of a 12-year old female patient who presented in outpatient clinic with a short period history of headache and seizures. A CT scan showed a large right sided frontal space occupying lesion with areas of calcification. The patient was operated and subsequent histopathology revealed a high-grade astrocytic tumor with increased cellularity, atypical mitosis, bizarre multinucleated giant cells along with large areas of ischemic necrosis and calcification. A diagnosis of Giant cell glioblastoma (WHO Grade IV) was made. The patient was symptomatically well at 3-month follow-up.
https://ijp.iranpath.org/article_8546_e435d4de7d6a1bc915acb8af2895753f.pdf
2011-06-01
153
157
Giant Cell Glioblastomas
Children
Indranil
Chakrabarti
dr.inch@yahoo.co.in
1
Dept. of Pathology, North Bengal Medical College, Siliguri, India
LEAD_AUTHOR
Nilanjana
Ghosh
2
Dept. of Community Medicine, North Bengal Medical College, Siliguri, India
AUTHOR
ORIGINAL_ARTICLE
Primary Intraosseous Carcinoma of the Maxilla
A primary intraosseous carcinoma (PIOC) is a squamous cell carcinoma arising within the jawbone andshould be differentiated from a malignant ameloblastoma. It is not due to arising from an odontogenic cyst or tumor. The possibility of the lesion being a metastasis fromanotherprimary site should be considered, and excluded by a careful history and examination. The diagnosis of a PIOC is rare, but it is often worth considering in any differential diagnosis of jawradiolucency. The prognosis associated with primary intraosseous carcinoma of the jaws is poor and needs for aggressive treatment. It is common for these patients to present with apparent routine dental.This paper reports a case PIOC of the maxilla. The patient was a 68-year-old woman with a chief complaint of swelling of her hard palate.
https://ijp.iranpath.org/article_8548_014d09c203beb138d91e34bcf2eec0c9.pdf
2011-06-01
158
163
Squamous cell carcinoma
Maxillae
Maryam
Alsadat Hashemipour
m_s_hashemipour@yahoo.com
1
Kerman Oral and Dental Diseases Research Center, Kerman, Iran
LEAD_AUTHOR
Shahrzad
Adhami
2
Dept. of Oral Pathology, Faculty, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Behroz
Mozafari
3
Dept. of Oral & Maxillofacial Surgery, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Fatemeh
Ahmadi Motemail
4
Dept. of Oral Medicine, Hamedan University of Medical Sciences, Hamedan, Iran
AUTHOR
ORIGINAL_ARTICLE
Quantitative Dengue Test: Is it Practical for Clinical Practice?
https://ijp.iranpath.org/article_8549_c2096ae34eea23c0d62d7bbbfa2b9b83.pdf
2011-06-01
164
164
Viroj
Wiwanitkit
wviroj@yahoo.com
1
Thai POCT forum coordinator, Bangkok, Thailand Correspondence
LEAD_AUTHOR
Lindholm PF, Annen K, Ramsey G. Approaches to Minimize Infection Risk in Blood Banking and Transfusion Practice. Infect Disord Drug Targets. 2010 Aug 10.
1
Kao CL, King CC, Chao DY, Wu HL, Chang GJ. Laboratory diagnosis of dengue virus infection: current and future perspectives in clinical diagnosis and public health. J Microbiol Immunol Infect. 2005 Feb,38(1):5-16.
2