%0 Journal Article %T The Effect of Two Different Doses of Atorvastatin on Lipoprotein-A on Patients with Acute Coronary Syndrome %J Iranian Journal of Pathology %I Farname Inc in collaboration with Iranian Society of Pathology %Z 1735-5303 %A Zand Parsa, Amirfarhang %A Ashoori, Sara %A Abdollahi, Alireza %D 2012 %\ 04/01/2012 %V 7 %N 2 %P 101-106 %! The Effect of Two Different Doses of Atorvastatin on Lipoprotein-A on Patients with Acute Coronary Syndrome %K Atorvastatin calcium %K Lipoprotein A %K Acute Coronary Syndromes %R %X Background and Objectives: Lipoprotein-a potentially represents a useful tool for risk stratification in cardiovascular accidents.  The aim of this study was to evaluate the atorvastatin effect on serum lipid profile & lipoprotein A. Material & Methods: In 2009, 405 patients with acute coronary syndrome randomly were divided into 2 groups, taking 20 & 40 mg atorvastatin daily for 3 months. Lipid profile & lipoprotein-A serum levels were checked at the beginning of the study and also one and three months later. Results: There was no statistical difference between the two groups in all measurements except in patients with unstable angina. The difference lay in the change of LP-a level after one month (P=0.045) and in apo-A level in all patients in the second and the third measurements compared with the first one (P=0.001 & P=0.002). Discussion: It appears that the two doses (20mg and 40mg) of atorvastatin have a reduction effect on lipoprotein-A and serum lipid levels, but no difference is seen in the level of reduction. The 40 mg atorvastatin leaves more effects on reduction of apo-A than on the 20 mg after one and three months. %U https://ijp.iranpath.org/article_8366_040936f04e523300a0b0eeca1b5e7cb3.pdf