%0 Journal Article %T Retroperitoneal Anaplastic Neuroblastoma in a 3-Year-Old Female: A Rare Case Report %J Iranian Journal of Pathology %I Farname Inc in collaboration with Iranian Society of Pathology %Z 1735-5303 %A Roy, Shravasti %A Das, Indranil %A Nandi, Ayandip %A De, Soma %D 2015 %\ 07/01/2015 %V 10 %N 3 %P 227-230 %! Retroperitoneal Anaplastic Neuroblastoma in a 3-Year-Old Female: A Rare Case Report %K Neuroblastoma %K Retroperitoneal Space, Case Report %R 10.7508/ijp.2015.03.008 %X Neuroblastoma is the most common extracranial solid tumor in childhood. In different classification of neuroblastomas, a subset of undifferentiated or poorly differentiated tumors with bizarre histological features has been mentioned. A 3-year-old girl presented with abdominal pain. Her haematological and biochemical parameters were normal except her urinary vanelylmandelic acid level was elevated five times the normal value (64.4 IU/ml). On computed tomographyscan, a retroperitoneal contrast-enhancing mass was visible around D12-D13 region (60×52×47mm). Sections of CT guided trucut biopsy revealed large cells with pleomorphic nuclei, abundant cytoplasm and occasional multinucleated giant cells. Immunohistochemistry showed the cells reactive for neuron specific enolase, chromogranin-A, synaptophysin, non-reactive for cytokeratin, desmin and glial fibrillary acid protein and Alk-1. A diagnosis of anaplastic neuroblastoma was made. The child is currently under chemotherapy and doing well.   How to cite this article: Roy S, Das I, Nandi A, De S. Retroperitoneal Anaplastic Neuroblastoma in a 3-Year-Old Female: A Rare Case Report. Iran J Pathol. 2015;10(3):227-30. %U https://ijp.iranpath.org/article_11614_8b567093bbb7d39a05683a9e96b31f0c.pdf