eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
195
203
19723
Role of Immunohistochemistry in the Diagnosis of Solitary Fibrous Tumor, a Review
Bita Geramizadeh
geramib@sums.ac.ir
1
Mahsa Marzban
geramib1@gmail.com
2
Andrew Churg
3
Dept. of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
University of British Columbia, Vancouver, BC, Canada
Dept. of Pathology, Vancouver General Hospital and University of British Columbia, Vancouver , BC, Canada
Background: Solitary fibrous tumor (SFT) is a mesenchymal tumor which is most commonly seen in the pleura; however it can be seen in other organs such as the meninge, gastrointestinal tract, soft tissue, bone, and skin. SFT should be differentiated from other mesenchymal tumors in these organs. Immunohistochemistry plays a pivotal role for the histopathologic diagnosis of this tumor. Currently, new markers have been introduced which has been very useful for definite diagnosis of SFT along with other markers in each specific location which are negative in SFT. Methods: Here we review the reported positive and negative immunohistochemical markers of SFT in the English literature with the emphasis on the useful markers in each specific organ. We explored the English literature from 1990 through 2015 via PubMed, Google, and Google scholar using the following search keywords: Solitary fibrous tumor, Solitary fibrous tumor and immunohistochemistry, Solitary fibrous tumor and diagnosis, Solitary fibrous tumor and histogenesis, Solitary fibrous tumor and prognosis, Solitary fibrous tumor and hemangiopericytoma, Solitary fibrous tumor and differential diagnosis, Solitary fibrous tumor and markers. Results: The most important and valuable positive markers in SFT are CD34, CD99, Bcl-2 and STAT-6.There are consistently negative markers in this tumor as well, used according to the tumor location, such as EMA and S100 Conclusion: Immunohistochemistry is very useful for the diagnosis of solitary fibrous tumor and for its differentiation with other spindle cell mesenchymal tumor in different locations.
How to cite this article:
Geramizadeh B, Marzban M, Churg A. Role of Immunohistochemistry in the Diagnosis of Solitary Fibrous Tumor, a Review. Iran J Pathol. 2016; 11(3):195-293.
https://ijp.iranpath.org/article_19723_2d0e9efd0ea84ddf21f877b9852bbeea.pdf
Solitary Fibrous Tumor
Immunohistochemistry
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
204
209
19724
Evaluation of Aryoseven Safety (Recombinant Activated Factor VII) in Patients with Bleeding Disorders (An Observational Post-Marketing Surveillance Study)
Gholamreza Toogeh
gh.tooge@yahoo.com
1
Hassan Abolghasemi
2
Peyman Eshghi
peyman64@yahoo.com
3
Mohammadreza Managhchi
4
Mohammadreza Shaverdi-niasari
5
Katayoon Karimi
6
Samin Roostaei
7
Neda Emran
8
Alireza Abdollahi
dr_p_abdollahi@yahoo.com
9
Thromboses Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Thromboses Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
Thromboses Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
Thromboses Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
Thromboses Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
Thromboses Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
Thromboses Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
Background: Recombinant activated factor VII induces hemostasis in patients with coagulopathy disorders. AryoSeven™ as a safe Iranian Recombinant activated factor VII has been available on our market. This study was performed to establish the safety of AryoSeven on patients with coagulopathy disorder. Methods: This single-center, descriptive, cross sectional study was carried out in Thrombus and Homeostasis Research Center ValiAsr Hospital during 2013-2014. Fifty one patients with bleeding disorders who received at least one dose of Aryoseven were enrolled. Patients’ demographic data and adverse effect of drug and reaction related to Aryoseven or previous usage of Recombinant activated FVII were recorded in questionnaires. Finally data were analyzed to compare side effects of Aryoseven and other Recombinant activated FVII brands. Results: Aryoseven was prescribed for 51 Patients. Of all participants with mean age 57.18+21.38 yr, 31 cases were male and 26 subjects had past history of recombinant activated FVII usage. Glanzman was the most frequent disorder followed by congenital FVII deficiency, hemophilia with inhibitors, factor 5 deficiency, acquired hemophilia, hemophilia A with inhibitor, and hemophilia A or B with inhibitor. The majority of bleeding episodes had occurred in joints. Three patients (5.9%) complained about adverse effects of Aryoseven vs. 11.5 % about adverse effects of other brands. However this difference was not significant, statistically. Conclusion: Based on monitor patients closely for any adverse events, we concluded that Aryoseven administration under careful weighing of benefit versus potential harm may comparable with other counterpart drugs. How to cite this article: Toogeh G, Abolghasemi H, Eshghi P, Managhchi M, Shaverdi-niasari M, Karimi K, et al. Evaluation of Aryoseven Safety (recombinant activated factor VII) in patients with bleeding disorders (An observational post-marketing surveillance, study). Iran J Pathol. 2016; 11(3):204-9.
https://ijp.iranpath.org/article_19724_650ceeba52c0fc85a0817836cb94a1ba.pdf
Aryoseven
Safety
bleeding disorders
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
210
215
19725
BK Viremia among Iranian Renal Transplant Candidates
Manizheh Jozpanahi
dr.panahi48@gmail.com
1
Amitis Ramezani
amitisramezani@hotmail.com
2
Shahrzad Ossareh
ossareh_s@hotmail.com
3
Mohammad Banifazl
mohammadbanifazl@aol.com
4
Anahita Bavand
anahita_bvd@yahoo.com
5
Setareh Mamishi
smamishi@gmail.com
6
Arezoo Aghakhani
araghakhani@hotmail.com
7
Zanjan University of Medical Sciences, Zanjan, Iran
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
Hasheminejad Kidney Center, Iran University of Medical Science, Tehran, Iran
Iranian Society for Support of Patients with Infectious Diseases, Tehran, Iran
Clinical Research Dept., Pasteur Institute of Iran
Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
Background: Primary infection with BK virus (BKV) is occurred during childhood and usually asymptomatic, but after initial infection, BKV may persist lifelong in the kidney and genitourinary tract. Reactivation may occur in individuals with compromised immunity such as renal transplant recipients. Due to the role of BKV in BK virus-associated nephropathy (BKVAN) and potentially renal allograft rejection, the detection of BKV in renal transplant candidates is very important. The aim of this study was to evaluate the frequency of BK viremia in end stage renal disease cases who were candidates for renal transplantation. Methods: In this cross-sectional study, 50 cases with end stage renal disease who were candidates for renal transplantation were recruited from the main dialysis unit in Tehran, Iran. Presence of BK viremia was determined in plasma samples of cases using real time PCR. Results: A total of 50 renal transplant candidates with mean age 37.8±13 yr were enrolled in the study. Fifty two percent of subjects were male. Forty six (92%) of them were under HD and 4 (8%) were on PD. BK virus was not detected in any plasma samples of renal transplant candidates. Conclusion: This study showed absence of BK viremia in our renal transplant candidates. However, due to the important role of BKV in BKVAN and renal graft failure and rejection, further studies involving larger number of cases are required to elucidate the rate of the BKV in renal transplant candidates.
How to cite this article:
Jozpanahi M, Ramezani A, Ossareh S, Banifazl M, Bavand A, Mamishi S, et al. BK Viremia among Iranian Renal Transplant Candidates. Iran J Pathol. 2016; 11(3):210-5.
https://ijp.iranpath.org/article_19725_c6c8fe241477d519e1c3eab6d8aae293.pdf
BK virus (BKV)
Prevalence
Renal transplant candidates
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
216
221
19286
Polymorphism of IL-28B Gene (rs12979860) in HCV Genotype 1 Patients Treated by Pegylated Interferon and Ribavirin
Fahimeh Safarnezhad Tameshkel
fahime.1615@yahoo.com
1
Mohmmad Hadi Karbalaie Niya
karbalai.m2011@gmail.com
2
Masuodreza Sohrabi
sohrab_r@yahoo.com
3
Mahshid Panahi
mahshid.panahi@yahoo.com
4
Farhad Zamani
zamani.farhad@gmail.com
5
Farid Imanzade
n_rakhshani@yahoo.com
6
Nasser Rakhshani
mohamad.karbalai@yahoo.com
7
Gastrointestinal & Liver Disease Research Center (GILDRC), Iran University of Medical Sciences, Tehran, Iran
Dept. of Virology, Iran University of Medical Sciences, Tehran, Iran
Gastrointestinal & Liver Disease Research Center (GILDRC), Iran University of Medical Sciences, Tehran, Iran
Gastrointestinal & Liver Disease Research Center (GILDRC), Iran University of Medical Sciences, Tehran, Iran
Gastrointestinal & Liver Disease Research Center (GILDRC), Iran University of Medical Sciences, Tehran, Iran
Dept. of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Gastrointestinal & Liver Disease Research Center (GILDRC), Iran University of Medical Sciences, Tehran, Iran
Background: Nowadays, the immune response to hepatitis C (HCV) treatment has become a crucial issue mostly due to the interleukin 28B (IL-28B) polymorphism effects in chronic HCV patients. The aim of this study was to detect the polymorphism of IL-28B gene (rs12979860) in HCV genotype 1 patients treated with pegylated Interferon and Ribavirin. Methods: From the 2010 to 2012, a total of 115 peripheral blood mononuclear cells (PBMCs) of HCV patients who presented to Gastrointestinal & Liver Disease Research Center (GILDRC), Firoozgar Hospital, Tehran, Iran were enrolled in this retrospective cross sectional study. Samples were then categorized based on the presence of sustained virologic response (SVR and no-SVR). Variables including age, gender, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels of the two groups were investigated based on different IL-28B genotypes. Results: Analysis by the variables of age and gender showed a mean age ± SD of 42.1±14.0 and gender variability of 44 females (38.2%) and 71 males (61.8%). Adding up these results, the analysis of ALT levels revealed that there was between 293 and 14 mg/ml; AST levels ranged between 217 and 17 mg/ml; the viral load (HCV RNA) ranged between 7,822,000 and 50 IU/ml; the prevalence of CC, CT and TT genotypes were 90.9%, 54% and 25.0%. Conclusion: IL-28B polymorphism has an effective impact on the therapeutic response to ribavirin and peginterferon combination therapy in chronic HCV patients infected by different genotypes. This polymorphism is crucial in natural clearance.
How to cite this article:
Safarnezhad Tameshkel F, Karbalaie Niya MH, Sohrabi M, Panahi M, Zamani F, Imanzade F, et al. Polymorphism of IL-28B Gene (rs12979860) in HCV Genotype 1 Patients Treated by Pegylated Interferon and Ribavirin. Iran J Pathol. 2016; 11(3):216-21.
https://ijp.iranpath.org/article_19286_99660f0ba19c08b902097f75a22fd76a.pdf
Chronic HCV infection
Sustained virologic response
Interleukin 28B polymorphism
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
222
230
19287
Designing and Development of a DNA Vaccine Based On Structural Proteins of Hepatitis C Virus
Roghayeh Teimourpour
r.teymourpour@gmail.com
1
Amineh Sadat Tajani
tajania891@mums.ac.ir
2
Vahid Reza Askari
askariv891@mums.ac.ir
3
Sina Rostami
sina.rostami@student.uib.no
4
Zahra Meshkat
meshkatz@mums.ac.ir
5
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Pharmacy School, Mashhad University of Medical Sciences, Mashhad, Iran
Pharmacy School, Mashhad University of Medical Sciences, Mashhad, Iran
The Influenza Centre, Department of Clinical Science, University of Bergen, N-5021 Bergen, Norway
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Background: Hepatitis C virus (HCV) infection is one of the most prevalent infectious diseases responsible for high morbidity and mortality worldwide. Therefore, designing new and effective therapeutics is of great importance. The aim of the current study was to construct a DNA vaccine containing structural proteins of HCV and evaluation of its expression in a eukaryotic system. Methods: Structural proteins of HCV (core, E1, and E2) were isolated and amplified from JFH strain of HCV genotype 2a using PCR method. The PCR products were cloned into pCDNA3.1 (+) vector and finally were confirmed by restriction enzyme analysis and sequencing. The eukaryotic expression of the vector was confirmed by RT-PCR. Results: Recombinant vector containing 2241bp fragment of HCV structural genes was constructed.The desired plasmid was sequenced and corresponded to 100% identity with the submitted sequences in GenBank. RT-PCR results indicated that the recombinant plasmid could be expressed efficiently in the eukaryotic expression system. Conclusion: Successful cloning of structural viral genes in pCDNA3.1 (+) vector and their expression in a eukaryotic expression system facilitates the development of new DNA vaccines against HCV. A DNA vaccine encoding core-E1-E2 antigens was designed. The desired expression vector can be used for further attempts in the development of vaccines.
https://ijp.iranpath.org/article_19287_5449388f49745a817746877a385b272e.pdf
HCV
Structural proteins
DNA Vaccine
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
231
237
19726
Expression of Vascular Endothelial Growth Factor in Nasal Polyp and Chronic Rhinosinusitis
Alireza Azizzadeh Delshad
delshada@yahoo.com
1
Mohammadreza Jalali Nadoushan
jalalinadooshan@yahoo.com
2
Ali Davati
davati@shahed.ac.ir
3
Aida Rostami
aidarostami@gmail.com
4
Dept. of Anatomical Sciences and Pathology, Faculty of Medicine, Shahed University, Tehran, Iran
Dept. of Anatomical Sciences and Pathology, Faculty of Medicine, Shahed University, Tehran, Iran
Dept. of Anatomical Sciences and Pathology, Faculty of Medicine, Shahed University, Tehran, Iran
Dept. of Anatomical Sciences and Pathology, Faculty of Medicine, Shahed University, Tehran, Iran
Background: Nasal inflammatory disorders such as chronic rhinosinusitis and nasal polyp are among the most prevalent complications with high socioeconomic costs. Vascular Endothelial Growth Factor (VEGF) plays a key role in angiogenesis and cell proliferation. In the present study the effect of VEGF on the development and prognosis of chronic rhinosinusitis and nasal polyp was investigated. Methods: This cross sectional study was performed on the nasal histological specimens of two groups of patients suffering from nasal polyp or chronic rhinosinusitis, and the expression of VEGF in the two groups was compared immunohistochemically. Based on the percentage of VEGF-positive cells the specimens were classified into four scores. Furthermore, the relations between the VEGF expression and some demographic characteristics were evaluated. Results: The VEGF immunohistochemistry findings indicated a significantly higher expression of VEGF in nasal polyp group compared to chronic rhinosinusitis without nasal polyp group. In terms of VEGF-expression scoring, in both groups most of the specimens were classified as score-2, namely indicating 10-50% of VEGF-positive epithelial cells. In both groups no significant relation between VEGF expression and age or sex of the patients could be seen. Conclusion: Local modulation of VEGF expression might be taken as a putative therapeutic strategy in management of sinunasal inflammatory disorders, especially nasal polyps.
https://ijp.iranpath.org/article_19726_df713ddb7727bfd7d7f7ef12f4f37feb.pdf
VEGF
Nasal polyp
Chronic rhinosinusitis
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
238
247
19727
Species-specific PCR for the Diagnosis and Determination of Antibiotic Susceptibilities of Brucella Strains Isolated from Tehran, Iran
Faramarz Masjedian Jazi
fmasjedian@yahoo.com
1
Gholamreza Irajian
dr.irajian@gmail.com
2
Reza Mirnejad
rmirnejad@bmsu.ac.ir
3
Vahhab Piranfar
vahab.p@gmail.com
4
Taghi zahraei salehi
tsalehi@ut.ac.ir
5
Noor Amir Mozafari
amirmozafari@yahoo.com
6
Ehsanollah Ghaznavi-rad
e.ghaznavirad@arakmu.ac.ir
7
Mahmoud Khormali
mkhoramali@ut.ac.ir
8
Dept. of Microbiology, Iran University of Medical Sciences, Tehran. Iran
Dept. of Microbiology, Iran University of Medical Sciences, Tehran. Iran
Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Dept. of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Dept. of Microbiology, Iran University of Medical Sciences, Tehran. Iran
Dept. of Microbiology and Immunology, Arak University of Medical Sciences, Arak, Iran
Dept. of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Background: Brucellosis is an endemic zoonotic disease in the Middle East. This study intended to design a uniplex PCR assay for the detection and differentiation of Brucella at the species level and determining the antibiotic susceptibility pattern of Brucella in Iran. Methods: Sixty-eight Brucella specimens (38 animal and 30 human specimens) were analyzed using PCR (using one pair of primers). Antibiotic susceptibility patterns were evaluated and compared using the E-Test and disk diffusion susceptibility test. Tigecycline susceptibility pattern was compared with other antibiotics. Results: Thirty six isolates of B. melitensis, 2 isolates of B. abortus and 1 isolate of B. suis from the 38 animal specimens, 24 isolates of B. melitensis and 6 isolates of B. abortus from the 30 human specimens were differentiated. The MIC50 values of doxycycline for human and animal specimens were 125 and 10 μg/ml, respectively, tigecycline 0.064 μg/ml for human specimens and 0.125μg/ml for animal specimens, and trimethoprim/ sulfamethoxazole and ciprofloxacin 0.065 and 0.125μg/ml, respectively, for both human and animal specimens. The highest MIC50 value of streptomycin in the human specimens was 0.5μg/ml and 1μg/ml for the animal specimens. The greatest resistance shown was to tetracycline and gentamicin, respectively. Conclusion: Uniplex PCR for the detection and differentiation of Brucella at the strain level is faster and less expensive than multiplex PCR, and the antibiotics doxycycline, rifampin, trimethoprim-sulfamethoxazole, ciprofloxacin, and ofloxacin are the most effective antibiotics for treating brucellosis. Resistance to tigecycline is increasing, and we recommend that it be used in a combination regimen.
https://ijp.iranpath.org/article_19727_23d4de1c48a70a48acaf0df248ee267c.pdf
Uniplex PCR
Brucella
Antibiotic Susceptibilities
Tigecycline
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
248
254
19728
The Oral Pathology Related Articles Published in Iranian Journal of Pathology from 2006 to 2015
Thorakkal Shamim
shamu3duad@gmail.com
1
Dept. of Dentistry, Oral Pathology and Microbiology, Government Taluk Head Quarters Hospital, Malappuram, India
Background: There is a paucity of information about the oral pathology related articles published in a pathology journal. This study aimed to audit the oral pathology related articles published in Iranian Journal of Pathology (Iran J Pathol)from 2006 to 2015. Methods: Bibliometric analysis of issues of Iran J Pathol from 2006 to 2015 was performed using web-based search.The articles published were analyzed for type of article and individual topic of oral pathology. The articles published were also checked for authorship trends. Results: Out of the total 49 published articles related to oral pathology, case reports (21) and original articles (18) contributed the major share. The highest number of oral pathology related articles was published in 2011, 2014 and 2015 with 8 articles each and the least published year was 2012 with 1 article. Among the oral pathology related articles published, spindle cell neoplasms (7) followed by salivary gland tumors (5), jaw tumors (4), oral granulomatous conditions (4), lymphomas (4), oral cancer (3) and odontogenic cysts (3) form the major attraction of the contributors. The largest numbers of published articles related to oral pathology were received from Tehran University of Medical Sciences; Tehran (7) followed by Mashhad University of Medical Sciences, Mashhad (6) and Shahid Beheshti University of Medical Sciences, Tehran (5). Conclusion: This paper may be considered as a baseline study for the bibliometric information regarding oral pathology related articles published in a pathology journal.
https://ijp.iranpath.org/article_19728_e8dfcb88ee4f0d823adc4b125b9253fc.pdf
Oral Pathology
Iranian Journal of Pathology
Bibliometric analysis
Pathology Journal
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
255
260
19729
Demsoplastic Small Round Cell Tumor:a Diagnostic and Therapeutic Dilemma
Moeinadin Safavi
moein.safavi@gmail.com
1
Jahanbanoo Shahryari
jshahryari@yahoo.cam
2
Mohammadmehdi Moeini Aghtaei
moini_m@yahoo.com
3
Hossein Nikpour
hakimlab@yahoo.com
4
Dept. of Pathology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Dept. of Pathology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Dept. of Pathology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Dept. of Pathology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Desmoplastic small round cell tumor (DSCRT) is a rare variant of sarcoma with a highly aggressive behavior. It usually affects abdominal cavity and has a male predominance. Its correct diagnosis and treatment is sophisticated and requires an experienced multidisciplinary team. Hereby we present a 25 yrold man from Kerman Province in 2013 with abdominal mass and ascites who underwent sonograghy guided percutaneous needle biopsy which was misleading and inconclusive for diagnosis. Thus an open biopsy was fulfilled which revealed solid nests of small round cells with hyperchromatic nuclei and clear cytoplasm surrounded by a desmoplastic stroma suggestive for DSCRT. The diagnosis was confirmed by positive immunohitochemical reaction for cytokeratin, desmin and neuron specific enolase(NSE).Ultimately the patient underwent chemotherapy on the basis of P6 protocol without surgical debulking.Diagnosis and treatment of DSCRT could be a dilemma due to its rarity, various clinicopathologic mimickers and lack of a consensus about its management.
https://ijp.iranpath.org/article_19729_6f1cd2bfb36032bdbd2af5ce52a2d8d4.pdf
Desmoplastic small round cell tumor
pathology
chemotherapy
needle biopsy
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
261
264
19730
Round Ligament Leiomyoma Developing During Pregnancy: A Case Report and Literature Review
Recep Bedir
bedirrecep@gmail.com
1
Rukiye Yilmaz
dr.rukiyeyilmaz@gmail.com
2
İbrahim Sehitoglu
sehitogluibrahim@gmail.com
3
Cuneyt Yurdakul
cuneytyurdakul@yahoo.com
4
Dept. of Pathology, Recep Tayyip Erdogan University School of Medicine, Rize, Turkey
Dept. of Pathology, Recep Tayyip Erdogan University School of Medicine, Rize, Turkey
Dept. of Pathology, Recep Tayyip Erdogan University School of Medicine, Rize, Turkey
Dept. of Pathology, Recep Tayyip Erdogan University School of Medicine, Rize, Turkey
Round ligament leiomyoma of uterus is rare. It can be presented as inguinal swelling mimicking the inguinal hernia or lymph node. Surgical excision is its curative treatment. Definitive diagnosis is made by histopathological examination. A 32 year old pregnant patient having round ligament leiomyoma as diagnosed histopathologically in Recep Tayyip Erdogan University Hospital in 2014 was presented here as the sixth case in literature.
https://ijp.iranpath.org/article_19730_f99072642f7cd3afaf9a8c1a33dd5bdf.pdf
Leiomyoma
Pregnant
Inguinal mass
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
265
271
19731
Association of Macrophage Activating Syndrome with Castleman’s Syndrome in Systemic Lupus Erythematosus
Shamsa Shariatpanahi
shariat15@yahoo.com
1
Shahryar Pourfarzam
shahr773@hotmail.com
2
Mohammad hosein Gheini
ghaini46@yahoo.com
3
Dept. of Internal Medicine, Shahed University, Tehran, Iran
Dept. of Pathology, Shahed University, Tehran, Iran
Dept. of Pathology, Shahed University, Tehran, Iran
Macrophage Activating Syndrome (MAS) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, Still's disease, polyarteritis nodosa. It is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. A 27 yr. old female patient was admitted in shahid Mostafa Khomeini Hospital (Tehran-Iran) in May 2011 because of lower extremities edema and ascites and fever from 1.5 month ago. In physical examinations she had generalized lymphadenopathy, splenomegaly and pleural effusion. In laboratory tests she had pancytopenia, positive ANA and Anti DNA (ds), hypocomplementemia, hypertriglyceridemia and high ferritin level. Gradually she had signs of RPGN and ARDS. The patient had no skin and musculoskeletal signs of SLE and no liver failure nor coagulopathy of MAS. Her lymph node biopsy was reported as Castleman syndrome. Unlike other studies, the patient showed MAS before treatment with cytotoxic for lupus nephritis.
https://ijp.iranpath.org/article_19731_8a47519907700d0a2ce190df9f7b3c45.pdf
Systemic Lupus Erythematosus
Macrophage activating syndrome hemophagocytic lymphohistiosytosis
Castleman syndrome
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
272
275
19732
Cytodiagnosis of Chondromyxoid Fibroma of the Metatarsal Head: A Case Report
Bushra Siddiqui
bushrasiddiqui85@yahoo.com
1
Shahbaz Habib Faridi
shahbazfaridi@yahoo.com
2
Mohd Faizan
mohdfaizan2002@gmail.com
3
Syed Ahmad
drshahbazfaridi@gmail.com
4
Rana K Sherwani
drranak_sherwani65@yahoo.com
5
Dept. of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Dept. of Surgery, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Dept. of Orthopaedics, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Department of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Dept. of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Chondromyxoid fibroma (CMF) is a rare benign cartilaginous tumor with a predilection for the bones of lower extremities and about one fourth of the tumors involve the foot.Radiologically, an eccentric lytic lesion with well defined margins is seen in the metaphysis of the bone. We hereby, report an 18 yr old young male who presented to Orthopedic Outpatient Department, JN Medical College, Aligarh Muslim University, India diagnosed with giant cell tumor of thethird metatarsal bone of right foot on radiography but on fine needle aspiration cytology (FNAC) the diagnosis of CMF was made. Preoperative diagnosis of this benign condition helped in doing minimum surgical intervention in the form of curettage along with bone grafting. Histopathology further confirmed the diagnosis of CMF. The case is being discussed to highlight the importance of FNAC to diagnose these uncommon benign bone lesions.
https://ijp.iranpath.org/article_19732_8cee28d256ab4e0da58bc6580c75b4fd.pdf
Chondromyxoid fibroma (CMF)
Cytodiagnosis
Metatarsal bone
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
276
280
19733
Multifocal Central Giant Cell Granuloma - A Case Report
Tamgadge Sandhya
avinash.pt@gmail.com
1
Tamgadge Avinash
sandhya.tamgadge@gmail.com
2
Dhauskar Snehal
snehal0489@gmail.com
3
Tiwari Neha
drneha.1188@yahoo.com
4
Mudaliar Uma
uma.nm88@gmail.com
5
Dept. of Oral & Maxillofacial Pathology and Microbiology Dr D Y Patil Dental College & Hospital, Sector 7, Nerul, Navi Mumbai, Maharashtra, India.
Dept. of Oral & Maxillofacial Pathology and Microbiology Dr D Y Patil Dental College & Hospital, Sector 7, Nerul, Navi Mumbai, Maharashtra, India.
Dept. of Oral & Maxillofacial Pathology and Microbiology Dr D Y Patil Dental College & Hospital, Sector 7, Nerul, Navi Mumbai, Maharashtra, India.
Dept. of Oral & Maxillofacial Pathology and Microbiology Dr D Y Patil Dental College & Hospital, Sector 7, Nerul, Navi Mumbai, Maharashtra, India.
Dept. of Oral & Maxillofacial Pathology and Microbiology Dr D Y Patil Dental College & Hospital, Sector 7, Nerul, Navi Mumbai, Maharashtra, India.
Central giant cell granuloma is a benign, aggressive neoplasm composed of multinucleated giant cells that almost exclusively occurs in the jaws though extra-gnathic incidence is rare.Multifocal CGCGs of the jaws are very rare and suggestive of systemic diseases such as hyperparathyroidism,an inherited syndrome such as Noonan-like multiple giant cell lesion syndrome or other disorders.Very few cases of multifocal CGCGs in the jaws without any concomitant systemic disease have been reported. This paper describes an unusual case reported to the Oral Surgery Department of Dr. D.Y.Patil Dental College & Hospital, Nerul, Navi-Mumbai in 2014ina45-year-old male with multifocal central giant cell granuloma involving maxilla and mandible. The serum alkaline phosphatase, calcium and phosphorus levels were within the normal limits. After complete clinical examination hyperparathyroidism and clinical characteristic of any syndromes such as Noonan-like syndrome and neurofibromatosis were ruled out. Thus this paper reports a non-syndromic multifocal central giant cell granuloma.
https://ijp.iranpath.org/article_19733_9113cc150f224878b70c1a476d879730.pdf
Giant cell
Hyperthyroidism
Multifocal
Syndromes
Maxilla
Mandible
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
281
285
19734
Meningeal Hemangiopericytoma in 33-Year-Old Female; a Case Report
Alireza Abdollahi
dr_p_abdollahi@yahoo.com
1
Reyhaneh Abdollahpouri
reihaneh.abdollahpouri@gmail.com
2
Seyed-Mohammad Tavangar
tavangar@ams.ac.ir
3
Dept. of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Dept. of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Dept. of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Intracranial hemangiopericytomas (HPC) are rare vascular tumors. They account for 0.4% of primary central nervous system tumors. HPC is more commonly located supratentorially and tends to occur in a younger age group, with average age at presentation of 38–42 years. The tumor was found throughout the entire CNS, usually superficially and closely related to the meninges. Moreover, they have a strong tendency for local recurrence and extracranial metastasis. Given the clinical, pathological and imaging similarities between Hemangiopericytoma and angioblastic/anaplastic meningioma and the necessity of differentiating these two (choosing the proper treatment and prognosis), we present a report of meningeal Hemangiopericytoma tumor in a 33-year-old female. Our study suggests that in addition to routine histopathological examination, immunohistochemical study is essential to differentiate it from other differential diagnosis. How to cite this article: Abdollahi A, Abdollahpouri R,Tavangar SM. Meningeal Hemangiopericytoma in a 33-yr-Old Female; a Case Report. Iran J Pathol. 2016; 11(3):281-5.
https://ijp.iranpath.org/article_19734_00f7f8cf0a4c02ce38f213fc5590db90.pdf
Meningeal Hemangiopericytoma
Intracranial Tumors
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
286
290
19735
A Tete – a – tete of benign, borderline and malignant fibrohistiocytic tumor
RASHMI M.V.
rashmiarava@yahoo.com
1
Pavithra P
drpavithra83@gmail.com
2
Shivakumarappa G.M.
drgeethajp@gmail.com
3
Dept. of Pathology, Sri Siddhartha Medical College, Tumkur, Karnataka – 572104, India
Dept. of Pathology, Sri Siddhartha Medical College, Tumkur, Karnataka – 572104, India
Dept. of Surgery, Sri Siddhartha Medical College, Tumkur, Karnataka – 572104, India
Dermatofibrosarcoma protruberans is a relatively uncommon slow growing, locally aggressive fibrous tumor of the skin. It has a prospensity of progressing to fibrosarcomatous change in 5% of the cases. We present a case of a 56 yr old male with presented to the outpatient department of surgery, Sri Siddhartha Medical College, Tumkur with a chest swelling in 2013. FNAC was inconclusive and the mass was excised. On histopathology, areas of benign fibrohistiocytic tumor, dermatofibrosarcoma protruberans and fibrosarcomatous dermatofibrosarcoma were identified in the same tumor. Immunohistochemistry confirmed the diagnosis of DFSP with fibrosarcomatous change. Although, transformed DFSP is more aggressive, the prognosis is influenced by the extent of excision and with wide excision, there may be little increased risk for recurrence and metastasis over that of conventional DFSP.
https://ijp.iranpath.org/article_19735_e23b9a5cae226d1516b9612dd4b3b10d.pdf
Benign fibrohistiocytic tumor
Dermatofibrosarcoma protruberans
Fibrosarcomatous dermatofibrosarcoma protruberans
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
291
295
20532
Meningioangiomatosis in an otherwise healthy 13 year-old boy: A case report with emphasis on histopathological findings
Dorna Motevalli
dmotevalli@yahoo.com
1
Naser Kamalian
kamalian@tums.ac.ir
2
Seyed Mohammad Tavangar
tavangar@ams.ac.ir
3
Dept. of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Dept. of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Dept. of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Meningioangiomatosis is regarded as a rare benign hamartomatous condition mostly involving the cerebral cortex and overlying leptomeninges. A strong association of MA with neurofibromatosis type 2 has been documented in published articles. Herein we report a case of an otherwise healthy 13-year-old boy with no family history or stigmata of neurofibromatosis who presented with intractable seizures. MRI revealed a 2x2 cm mass lesion in the frontal lobe. The patient underwent complete surgical resection of the lesion. Although the primary radiologic impression of the lesion was glioma, pathological evaluation of the resected specimen showed mainly proliferation of meningothelial cells and fibroblast-like cells with many thickened blood vessels, which are typical for diagnosis of meningioangiomatosis. After surgical removal of the lesion, the patient is free of seizures. How to cite this article: Motevalli D, Kamalian N, Tavangar SM. Meningioangiomatosis in an otherwise healthy 13 year-old boy: A case report with emphasis on histopathological findings. Iran J Pathol. 2016;11(3):291-5.
https://ijp.iranpath.org/article_20532_3e1c87adf80a9143d27c061ac88f5770.pdf
Meningioangiomatosis
sporadic
Seizure
Histopathology
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
296
297
19737
Spinal Intradural Extramedulary Capillary Hemangioma Mimicking Meningioma
Moeinadin Safavi
moein.safavi@gmail.com
1
Shahriar Dabiri
dabiri12@yahoo.com
2
Dept. of Pathology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Dept. of Pathology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Hemangiomas are considered as vascular malformations which are categorized by the type of vascular channel to capillary, cavernous, venous or arteriovenous(1). Their usual locations are soft tissue , cutaneous or subcutaneous tissue and bone especially vertebra(2).However, intradural extramedullary hemangiomas are rare and most of them fall in cavernous type category. Hereby, authors report a woman with spinal intradural extramedullary capillary hemangioma which is exceedingly rare.
https://ijp.iranpath.org/article_19737_0013bbf39b95a3b9cb02c91332cfd662.pdf
intradural tumor
capillary hemangioma
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
298
300
19738
Bilateral Cervical Lymphadenopathy- Need to Think Beyond Tuberculosis
Rupali Malik
drvickyster@gmail.com
1
Nisha Rana
nisharana@gmail.com
2
Department of Internal Medicine, VMMC and Safdarjang Hospital, New Delhi-110029, India
Department of Pathology, VMMC and Safdarjang Hospital, New Delhi-110029, India
Any patient with bilateral lymphadenopathy especially in Indian subcontinent is regarded as suffering from tuberculosis unless proved otherwise. This sometimes leads to unwarranted delay in correct diagnosis and management if there is ignorance regarding other rarer etiologies. Rosai-Dorfman Disease (RDD) may present in the same manner and should always be kept on the back of the mind to help avoid unnecessary empirical anti-tuberculous therapy that is usually prescribed in so called difficult-to-diagnose tuberculosis infections.
https://ijp.iranpath.org/article_19738_a541623f59b2965f4c29976f5e49c0f4.pdf
Rosai-Dorfman disease
tuberculosis
Lymphadenopathy
eng
Farname Inc in collaboration with Iranian Society of Pathology
Iranian Journal of Pathology
1735-5303
2345-3656
2016-07-01
11
3
301
302
19739
Pregnancies Complicated by Hemoglobin H disease
Beuy Joob
beuyjoob@hotmail.com
1
Viroj Wiwanitkit
wviroj@yahoo.com
2
Medical Academic Center, Bangkok, Thailand
Faculty of Medicine, University of Nis, Serbia Bangkok, Thailand.
Dear Editor-in-Chief The recent report on “The Adverse Effects of Pregnancies Complicated by Hemoglobin H (HBH) Disease” is very interesting (1). Rabiee et al. reported a pregnant case complicated with HBH disease. Indeed, this problem might not common in the Middle East but it is very common in Southeast Asia. The authors hereby would like to share the experience on this topic. In the recent report by Tongsong et al. (2), the maternal outcomes of normal mothers and those with HBH disease were not different. The common identified problems are fetal growth restriction, preterm birth and low birth weight (2).
https://ijp.iranpath.org/article_19739_f8ac8af9767525bbb2e46861c972117e.pdf
Pregnancy
Hemoglobin H disease