@article { author = {Chakrabarti, Indranil and Ghosh, Nilanjana}, title = {Giant Cell Glioblastoma -A Rare Pediatric Cerebral Neoplasm}, journal = {Iranian Journal of Pathology}, volume = {6}, number = {3}, pages = {153-157}, year = {2011}, publisher = {Farname Inc in collaboration with Iranian Society of Pathology}, issn = {1735-5303}, eissn = {2345-3656}, doi = {}, abstract = {Giant cell glioblastoma is an extremely rare variant of Glioblastoma (WHO grade IV) which is characterized by a predominance of bizarre, multinucleated giant cells. These tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. In pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. Here, we report a case of a 12-year old female patient who presented in outpatient clinic with a short period history of headache and seizures. A CT scan showed a large right sided frontal space occupying lesion with areas of calcification. The patient was operated and subsequent histopathology revealed a high-grade astrocytic tumor with increased  cellularity,  atypical  mitosis,  bizarre  multinucleated  giant  cells  along  with  large  areas  of ischemic  necrosis  and  calcification.  A  diagnosis  of  Giant  cell  glioblastoma  (WHO  Grade  IV)  was made. The patient was symptomatically well at 3-month follow-up.  }, keywords = {Giant Cell Glioblastomas,Children}, url = {https://ijp.iranpath.org/article_8546.html}, eprint = {https://ijp.iranpath.org/article_8546_e435d4de7d6a1bc915acb8af2895753f.pdf} }