@article { author = {Zand Parsa, Amirfarhang and Ashoori, Sara and Abdollahi, Alireza}, title = {The Effect of Two Different Doses of Atorvastatin on Lipoprotein-A on Patients with Acute Coronary Syndrome}, journal = {Iranian Journal of Pathology}, volume = {7}, number = {2}, pages = {101-106}, year = {2012}, publisher = {Farname Inc in collaboration with Iranian Society of Pathology}, issn = {1735-5303}, eissn = {2345-3656}, doi = {}, abstract = {Background and Objectives: Lipoprotein-a potentially represents a useful tool for risk stratification in cardiovascular accidents.  The aim of this study was to evaluate the atorvastatin effect on serum lipid profile & lipoprotein A. Material & Methods: In 2009, 405 patients with acute coronary syndrome randomly were divided into 2 groups, taking 20 & 40 mg atorvastatin daily for 3 months. Lipid profile & lipoprotein-A serum levels were checked at the beginning of the study and also one and three months later. Results: There was no statistical difference between the two groups in all measurements except in patients with unstable angina. The difference lay in the change of LP-a level after one month (P=0.045) and in apo-A level in all patients in the second and the third measurements compared with the first one (P=0.001 & P=0.002). Discussion: It appears that the two doses (20mg and 40mg) of atorvastatin have a reduction effect on lipoprotein-A and serum lipid levels, but no difference is seen in the level of reduction. The 40 mg atorvastatin leaves more effects on reduction of apo-A than on the 20 mg after one and three months.}, keywords = {Atorvastatin calcium,Lipoprotein A,Acute Coronary Syndromes}, url = {https://ijp.iranpath.org/article_8366.html}, eprint = {https://ijp.iranpath.org/article_8366_040936f04e523300a0b0eeca1b5e7cb3.pdf} }