@article { author = {Majdi, Mina and Saffar, Hana and Ghanadan, Alireza}, title = {Cutaneous Metaplastic Synovial Cyst: A Case Report}, journal = {Iranian Journal of Pathology}, volume = {11}, number = {5}, pages = {423-426}, year = {2016}, publisher = {Farname Inc in collaboration with Iranian Society of Pathology}, issn = {1735-5303}, eissn = {2345-3656}, doi = {}, abstract = {Cutaneous metaplastic synovial cyst (CMSC), presents as a solitary, tender subcutaneous nodule that usually occurs at the site of previous surgery or trauma. Histologically, the lesion is characterized by a cystic structure with villous-like projections that lined by metaplastic synovial tissue. The main cause remains unclear, but trauma is presumed to be a precipitating factor, as most reported cases have a history of antecedent cutaneous injury. Here we present a case of CMSC in a 51 yr old man, presented with a painless deep-seated dermal nodule in the medial aspect of left ankle without history of any trauma or surgery in this site. Immuno-histochemistry study reveals positive reaction for CD68 in the cystic wall and negative reactions for S-100. CMSC is a unique lesion and worthy to attention, and should be included in the differential diagnosis of deep dermal cutaneous cysts.}, keywords = {Metaplastic Synovial Cyst,Immunohistochemistry,Synovial Cyst}, url = {https://ijp.iranpath.org/article_23771.html}, eprint = {https://ijp.iranpath.org/article_23771_afc417a2689951b5d29e05f8c134dd31.pdf} }