Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Gynecologic Pathology
1. Expression of P63, P16 and CK17 in Atypical Squamous Metaplasia and Cervical Intraepithelial Neoplasia

Maryam Iranpour; Shahriar Dabiri; Mitra Rezazade; Fatemeh Bagheri

Articles in Press, Accepted Manuscript, Available Online from 26 December 2020


  Background & Objective: Cervical intraepithelial neoplasia (CIN) is a dysmaturation process in squamous cells in epithelial layer, which highly increases the risk of developing cervical cancer. The aim of this study was to compare the expression of three biomarkers, p16, p63, and CK17 in patients ...  Read More

Gynecologic Pathology
2. Mesonephric Adenocarcinoma of Uterine Cervix; A Case Report and Review of the Literature

Fatemeh Nili; Samaneh Salarvand; Hana Saffar; Bita Kalaghchi; Reza Ghalehtaki

Articles in Press, Accepted Manuscript, Available Online from 21 December 2020


  Mesonephric adenocarcinoma of the uterine cervix, an extremely rare tumor of the female genital tract, derives from the remnants of embryonic mesonephric ducts and its prognosis, diagnosis and treatment is rather challenging. We report a case of a 46-year-old woman with history of abnormal uterine bleeding ...  Read More

Gynecologic Pathology
3. Improvement of Targeted Chemotherapy of HER2-positive Ovarian Malignant Cell Line by ZHER2-Idarubicin Conjugate: An in vitro Study

Lila Siavoshinia; Mostafa Jamalan; Majid Zeinali; Aminollah Pourshohod; Mahdie Koushki; Bahman Moradipoodeh; Ghorban Mohammadzadeh

Articles in Press, Accepted Manuscript, Available Online from 20 December 2020


  Background & objectives: Overexpression of human epidermal growth factor receptor 2 (HER2) causes cell transformation and development of various types of malignancies. Idarubicin is an effective anti-neoplastic drug but specific delivery of it to the targeted cells is still a great challenge. Affibody ...  Read More

Gynecologic Pathology
4. Association of Human Papilloma Virus and Epstein-Barr Virus with Ovarian Cancer in Shiraz, Southwestern Iran

Mohammad Reza Shokouh; Akbar Safaie; Afagh Moattari; Jamal Sarvari

Volume 15, Issue 4 , Autumn 2020, , Pages 292-298


  Background & Objective:  Ovarian cancer is one of the most common cancers amongst women. The association of Human papillomavirus (HPV) and Epstein-Barr virus (EBV) with ovarian cancer is inconclusive; therefore, the aims of this study were to evaluate the frequency of HPV and EBV in malignant, ...  Read More

Gynecologic Pathology
5. Coexistence of Benign Brenner Tumor with Mucinous Cystadenoma in an Ovarian Mass

Farzaneh Nazari; Zahra Dehghani

Volume 15, Issue 4 , Autumn 2020, , Pages 334-337


  Ovarian cancer is the most lethal gynecologic malignancy. The surface epithelial tumor is the most common type of ovarian cancer. Among these, the mucinous tumors account for 10-15% of ovarian tumors. Mucinous ovarian tumors are among the most difficult ovarian neoplasms for surgical pathologists to ...  Read More

Gynecologic Pathology
6. Predicting Effects of Clinicopathological Variables on Her2 Gene Amplification by Chromogenic in situ Hybridization (CISH) in IHC Her2 (2+) Breast Cancer Patients; A Study from Iran

Mohammad Hashemi-Bahremani; Abdolali Ebrahimi; Mohaddese Fallahi

Volume 15, Issue 3 , Summer 2020, , Pages 217-224


  Background & Objective: The her2 amplification plays an important role in breast cancer management. Therefore, there is a need for using supplementary molecular methods in IHC equivocal cases. Present study has been conducted to determine the effects of clinicopathological variables on her2 gene ...  Read More

Gynecologic Pathology
7. Napsin-A Expression, a Reliable Immunohistochemical Marker for Diagnosis of Ovarian and Endometrial Clear Cell Carcinomas

Fatemeh Nili; Mansoureh Tavakoli; Narges Izadi-Mood; Hana Saffar; Soheila Sarmadi

Volume 15, Issue 2 , Spring 2020, , Pages 81-85


  Background & Objective: Clear cell carcinomas (CCC) differ from other types of ovarian and endometrial carcinomas in biology, behavior and response to chemotherapy. Histopathologic diagnosis may be challenging in some situations which necessitates immunohistochemistary (IHC) assessment. In this study ...  Read More

Gynecologic Pathology
8. Concurrence of Primary Cutaneous Extra Mammary Paget’s Disease and Squamous Cell Carcinoma in situ of Vulva: A Case Report

Fatemeh Samiee Rad; Sohayla Farajee

Volume 15, Issue 1 , Winter 2020, , Pages 48-52


  Extramammary Paget’s disease and vulvar intraepithelial neoplasia are common lesions of vulve, but synchronous occurrence is rare in a same location. Herein we describe a concurrence of primary cutaneous extra mammary Paget’s disease and squamous cell carcinoma in situ of vulva in an Iranian ...  Read More

Gynecologic Pathology
9. Absence of Human Papillomavirus in Benign and Malignant Breast Tissue

Maryam Kazemi Aghdam; Seyed Alireza Nadji; Azadeh Alvandimanesh; Maliheh Khoddami; Yassaman Khademi

Volume 14, Issue 4 , Autumn 2019, , Pages 279-283


  Background & Objective: Malignant breast tumors, which are one of the most important deadly cancers in women, like many other cancers, are proposed to be related to viruses etiologically. Proper management of breast carcinoma necessitates an identification of the etiological factors. Human Papilomavirus is ...  Read More

Gynecologic Pathology
10. Evaluation of HER2/neu Expression in High-Grade Endometrial Carcinoma and Its Clinicopathological Correlation

Soheila Sarmadi; Narges Izadi-Mood; Nazanin Mansourzadeh; Dorna Motevalli

Volume 14, Issue 4 , Autumn 2019, , Pages 322-328


  Background & Objective: Endometrial carcinoma (EC) has been traditionally classified into two distinct categories of low-grade and high-grade. Type I (low grade) EC, which constitutes the majority of cases, is linked to estrogen-related molecular pathways. But type II (high-grade) EC accounts for ...  Read More

Gynecologic Pathology
11. Comparing the Diagnostic Outcomes of Staining Various Breast Lesions with Either Anti-CK 5/6 or Anti-CK 5

Mihir A Gudi; Yiu Yi Chung; Nohadani Mahrokh

Volume 14, Issue 2 , Spring 2019, , Pages 113-121


  Background and Objective: Anti-CK5/6 monoclonal antibodies have an established role in breast disease diagnosis. Anti-CK5 monoclonal antibodies have recently become commercially available. There has been growing interest in the staining characteristics of anti-CK5 and its potential diagnostic role in ...  Read More

Gynecologic Pathology
12. Peripheral Primitive Neuroectodermal Tumor of the Ovary: The Report of Two Rare Cases

Fatemeh Nili; Azadeh Sedighi moghadam pour; Hedieh Moradi Tabriz; Parisa Sedighi Moghadam Pour; Hana Saffar

Volume 13, Issue 4 , Autumn 2018, , Pages 467-470

  Peripheral primitive neuroectodermal tumor (pPNET) is a highly aggressive small round cell tumor belonging to PNET/Ewing sarcoma family. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare. Herein we reported two cases of peripheral primitive neuroectodermal tumors of ovary ...  Read More

Gynecologic Pathology
13. Fallopian Tube Carcinoma In-situ in Endometrial Curettage

Nilay Nishith; Vidya Monappa; Ranjini Kudva

Volume 13, Issue 3 , Summer 2018, , Pages 363-367

  Background and Objective: Primary fallopian tube carcinomas (PFTC) are rare tumors with non-specific clinical presentations. The current case was unique since the tumor was first detected on endometrial curettage and clinicoradiologically was misdiagnosed as endometrial carcinoma.Case Report: A 48-year-old, ...  Read More

Gynecologic Pathology
14. Xanthogranulomatous Oophoritis: A Rare Case Report

Kaneeka Bhatnagar; Vikram Narang; Bhavna Garg; Neena Sood

Volume 13, Issue 3 , Summer 2018, , Pages 372-376

  Background and Objective: Xanthogranulomatous oophritis is an uncommon, non-neoplastic, chronic process in which the affected organ is destroyed by massive cellular infiltration of foamy histiocytes admixed with multinucleated giant cells, plasma cells, fibroblasts, neutrophils, and foci of necrosis. ...  Read More

Gynecologic Pathology
15. Hepatoid Variant of Yolk Sac Tumor of Both Ovaries With Widespread Intra-abdominal and Lung Metastasis: A Case Report

Srilatha Parampalli Srinivas; Archana Shivamurthy; Lakshmi Rao; Rajeshwari Gurumoorthy Bhat

Volume 13, Issue 2 , Spring 2018, , Pages 289-293


  Hepatoid variant of yolk sac tumor of ovary is an unusual tumor with an aggressive behavior. It is usually observed in young females, presents with abdominal complaints and is associated with raised α-fetoprotein (AFP) levels. It should be differentiated from other hepatoid tumors involving the ...  Read More

Gynecologic Pathology
16. Ovarian Small Cell Carcinoma: A Rare Case Report and Review of Literature

Savita Agarwal; Megha Ralli; Pinki Pandey; Shruti Singh

Volume 13, Issue 1 , Winter 2018, , Pages 99-102


  Ovarian small cell carcinoma is a rare and highly malignant tumor with poor prognosis. It usually presents in younger females with features of hypercalcemia. The exact histogenesis of the tumor is unclear and it may present as an undifferentiated tumor. In such cases, immunohistochemistry (IHC) plays ...  Read More

Gynecologic Pathology
17. Pseudopapillary and Macrofollicular Microscopic Growth Patterns in an Advanced Stage Ovarian Dysgerminoma: A Case Report

Fatemeh Nili; Niusha Noubari; Alireza Abdollahi

Volume 13, Issue 1 , Winter 2018, , Pages 94-98


  ysgerminoma is one of the two most common types of ovarian germ cell tumors. Providing accurate pathologic diagnosis and treatment planning, the prognosis is good even in advanced stages. Pathologic diagnosis is generally straightforward. In microscopic examination, the usual known growth patterns in ...  Read More

Gynecologic Pathology
18. Placental Mesenchymal Dysplasia With Normal Fetus: A Rare Case Report

Subrata Pal; Kingshuk Bose; Palash Ch Mondal; Srabani Chakrabarti; Mrinal Sikder

Volume 12, Issue 3 , Summer 2017, , Pages 307-310


  Placental mesenchymal dysplasia (PMD) is a rare benign placental abnormality. It is characterized by hydropic degeneration of stem villi, placentomegaly, and increased maternal serum alpha-fetoprotein(AFP). It can be associated with different congenital abnormalities, karyotype abnormalities, and feto-maternal ...  Read More

Gynecologic Pathology
19. The HER-2 as a Target Gene of Curcumin to Protect Hepatocytes Against the Arsenic-induced Carcinoma in Mice

Mahdi Ahadi; Vahid Naseh; Masoud Salehipour

Volume 12, Issue 2 , Spring 2017, , Pages 158-164


  Background & objective: The HER-2 gene is an important on co protein overexpressed in many types of cancers. The current study hypothesized that curcumin downregulates HER-2 and inhibits the signal transduction pathway of PI3K/Akt, MAPK, and activation of NFκB, which could be useful to treat ...  Read More

Gynecologic Pathology
20. Giant Cell Fibroma of the Buccal Mucosa with Laser Excision: Report of Unusual Case

Fatemeh Bagheri; Somayyeh Rahmani; Somayyeh Azimi; Jamileh Bigom Taheri

Volume 10, Issue 4 , Autumn 2015, , Pages 314-317


  Giant Cell Fibroma (GCF) was described as a new entity of fibrous hyperplastic soft tissue. It seems that stimulus from an unexplained origin can have a role in its etiology. Histopathologically GCF is consisted of multinucleated fibroblasts that have oval shape nuclei within the eosinophilic cytoplasm. ...  Read More