Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
1. Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission

Saeed Mirsadraee; Mihan Pourabdollah Toutkaboni; Mehrdad Bakhshayeshkaram; Mitra sadat Rezaei; Elham Askari; Sara Haseli; Nazanin Sadraee

Articles in Press, Accepted Manuscript, Available Online from 21 October 2020


  Background & Objective: Diagnosis of coronavirus disease 2019 (COVID-19) can be challenging, especially when the real­time quantitative reverse transcription polymerase chain reaction (RT-PCR) is not available or it is negative. In this study, we evaluated imaging and laboratory findings in a ...  Read More

2. Serology Testing for SARS-CoV-2: Benefits and Challenges

Mohammadreza Jalali Nadoushan; Soha Ahmadi; Paniz Jalali Nadoushan

Volume 15, Issue 3 , Summer 2020, , Pages 154-155


  As COVID-19 was declared as a pandemic by the World Health Organization (WHO) in March 2020, it is an emerging need to discuss different aspects of this pandemic. In any pandemic, valid and rapid laboratory diagnostic tests are critically important for early diagnosis, which will increase the rate of ...  Read More

3. Evaluation of Phenotypic and Genotypic Characteristics of Carbapnemases-producing Enterobacteriaceae and Its Prevalence in a Referral Hospital in Tehran City

Kosar Jalalvand; Nasrin Shayanfar; Freshteh Shahcheraghi; Elahe Amini; Masha Mohammadpour; Pegah Babaheidarian

Volume 15, Issue 2 , Spring 2020, , Pages 86-95


  Background & Objective: Carbapenem-resistant Enterobacteriaceae is a growing concern worldwide including Iran. The emergence of this pathogen is worrying as carbapenem is one of the 'last-line' antibiotics for treatment of infections caused by multi drug resistant gram- negative bacteria. The main ...  Read More

4. Persister cells formation and expression of type II Toxin-Antitoxin system genes in Brucella melitensis (16M) and Brucella abortus (B19)

Fatemeh Amraei; Negar Narimisa; Behroz Sadeghi; Vahid Lohrasbi; Faramarz Masjedian Jazi

Volume 15, Issue 2 , Spring 2020, , Pages 127-133


  Background & Objective: Persister cells are defined as a subpopulation of bacteria that are capable of reducing their metabolism and switching to dormancy in stress conditions. Persister cells formation has been attributed to numerous mechanisms, including stringent response and Toxin-Antitoxin (TA) ...  Read More

5. Assessment of Susceptibility to Five Common Antibiotics and Their Resistance Pattern in Clinical Enterococcus Isolates

Sara Masoumi Zavaryani; Reza Mirnejad; Vahhab Piranfar; Mehrdad Moosazadeh Moghaddam; Nikta Sajjadi; Somayyeh Saeedi

Volume 15, Issue 2 , Spring 2020, , Pages 96-105


  Background & Objective: Enterococcus Species are the common cause of nosocomial infections, which are highly resistant to different antibiotics. Therefore, determination of their antibiotic susceptibility patterns and simultaneous resistance to antibiotics is important for better treatment strategies. ...  Read More

6. Designing and Analyzing the Structure of DT-STXB Fusion Protein as an Anti-tumor Agent: An in Silico Approach

Zeynab Mohseni Moghadam; Raheleh Halabian; Hamid Sedighian; Elham Behzadi; Jafar Amani; Abbas ali Imani fooladi

Volume 14, Issue 4 , Autumn 2019, , Pages 305-312


  Background & Objective: A main contest in chemotherapy is to obtain regulator above the biodistribution of cytotoxic drugs. The utmost promising strategy comprises of drugs coupled with a tumor-targeting bearer that results in wide cytotoxic activity and particular delivery. The B-subunit of Shiga ...  Read More

7. Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Diabetic Foot Infection

Pegah Kananizadeh; Solmaz Ohadian Moghadam; Yasaman Sadeghi; Abbas Rahimi Foroushani; Hossein Adibi; Mohammad Reza Pourmand

Volume 14, Issue 4 , Autumn 2019, , Pages 329-337


  Background & Objective: Diabetic foot ulcer (DFU), is one of the most frequent causes for hospitalizations in patients with diabetes. A major problem in the treatment of DFU is the increased-incidence of methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to determine the ...  Read More

8. Association of Some High-Risk Mucosal Types of Human Papillomavirus with Cutaneous Squamous Cell Carcinoma in an Iranian Population

Hassan Ehteram; Mohaddeseh Sadat Mousavian; Tahereh Mazoochi; Tahereh Khamehchian; Mohammad Karimian

Volume 14, Issue 4 , Autumn 2019, , Pages 313-316


  Background & Objective: Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer that may be caused by Human papillomavirus (HPV), especially in immunosuppressed patients. However, the role of the mucosal types of HPV in SCC patients with normal immunity has not been extensively ...  Read More

9. Molecular Characterization of Community-Associated Methicillin-Resistant Staphylococcus aureus in Iranian Burn Patients

Samira Tajik; Shahin Najar Peerayeh; Bita Bakhshi; Reza Golmohammadi

Volume 14, Issue 4 , Autumn 2019, , Pages 284-289


  Background & Objective: Methicillin-resistant Staphylococcus aureus (MRSA) is reported as one of the important bacterial causes of burn wound infections. This study was carried out to investigate molecular characterization of community-associated MRSA (CA-MRSA) isolated from Iranian burn ...  Read More

10. Polymorphisms in Promoter Region of the Interferon - Gamma Receptor1 Gene and its Relation with Susceptibility to Brucellosis

Zahra Naseri; Nasrin Bahmani; Mohammad Yosef Alikhani; Seyed Hamid Hashemi; Ghodratollah Roshanaei

Volume 14, Issue 3 , Summer 2019, , Pages 206-211


  Background & Objective: Brucellosis is one of the most prevalent bacterial zoonotic diseases which afflicts both humans and animals. Genetic factors play an important role in susceptibility to brucellosis. One of these factors is interferon-gamma (IFN-g), which is vital in the defense mechanism against ...  Read More

11. The Prevalence of HPV Genotypes in Iranian Population: An Update

Mina Mobini Kesheh; Hossein Keyvani

Volume 14, Issue 3 , Summer 2019, , Pages 197-205


  Background & Objective: Human papillomavirus (HPV) is the main cause of genital warts and some anogenital cancers in male and female subjects which is commonly transmitted by sexual contacts. The objective of this cross-sectional study was to examine the prevalence of HPV genotypes in 10,266 Iranian ...  Read More

12. Bacteria Producing Extended Spectrum β-lactamases (ESBLs) in Hospitalized Patients: Prevalence, Antimicrobial Resistance Pattern and its Main Determinants

Mehdi Yousefipour; Mehrnaz Rasoulinejad; Azar Hadadi; Negin Esmaeilpour; Alireza Abdollahi; Siroos Jafari; Atieh khorsand

Volume 14, Issue 1 , Winter 2019, , Pages 61-67


  Background and Objective: There is a growing concern regarding the lack of new antibiotics, especially for multidrug-resistant bacteria that produce Extended Spectrum β-Lactamases (ESBLs). The present study aims to assess the prevalence of bacteria producing ESBLs, their antimicrobial resistance ...  Read More

13. Designing and Construction of a Cloning Vector Encoding mtb32C and mpt51 Fragments of Mycobacterium Tuberculosis as a DNA Vaccine Candidate

Faria Hasanzadeh Haghighi; Ehsan Aryan; Mohammad Derakhshan; Aida Gholoobi; Zahra Meshkat

Volume 13, Issue 4 , Autumn 2018, , Pages 403-407

  Background & objective:  Tuberculosis (TB) remains a major cause of death around the world. Bacillus Calmette Guérin (BCG) is the only vaccine used in TB prevention that has a protective effect in children, but its effectiveness declines in adults. Design and development of new vaccines ...  Read More

14. Growth Inhibitory Effect of Lactocare on Vibrio cholerae

Mahsa Asadi; Mohamad Fazeli; Azar Sabokbar

Volume 13, Issue 3 , Summer 2018, , Pages 301-307

  Background and Objective: Acute microbial diarrheal diseases are the major public health problems in the developing countries. People affected by diarrheal diseases have the lowest financial resources and poorest hygienic facilities. Children under five, primarily in Asian and African countries, are ...  Read More

15. Prevalence of blaOxacillinase-23 and blaOxacillinase-24/40 carbapenemase genes in Pseudomonas aeruginosa isolated from patients with nosocomial and non-nosocomial infections in West of Iran

Samaneh Rouhi; Rashid Ramazanzadeh

Volume 13, Issue 3 , Summer 2018, , Pages 348-356

  Background and Objective: Pseudomonas aeruginosa (P. aeruginosa) causes serious nosocomial and non-nosocomial infections. blaOxacillinases (OXA)-23 and blaOXA24/40 provide resistance to carbapenem antibiotics. The aim of this study was assessment of blaOXA-23 and blaOXA-24/40 in P. aeruginosa isolated ...  Read More

16. Development of Preventive Vaccines for Hepatitis C Virus E1/E2 Protein

Faezeh Ghasemi; Majid Ghayour Mobarhan; Hamed Gouklani; Zahra Meshkat

Volume 13, Issue 2 , Spring 2018, , Pages 113-124


  Hepatitis C virus (HCV) is responsible for a vast majority of liver failure cases. HCV is a kind of blood disease appraised to chronically infect 3% of the worlds’ population causing significant morbidity and mortality. Therefore, a complete knowledge of humoral responses against HCV, resulting ...  Read More

17. Development of Multiplex Reverse Transcription-Polymerase Chain Reaction for Simultaneous Detection of Influenza A, B and Adenoviruses

Mohsen Nakhaie; Hoorieh Soleimanjahi; Hamid Reza Mollaie; Seyed Mohamad Ali Arabzadeh

Volume 13, Issue 1 , Winter 2018, , Pages 54-62


  Background and objective:Millions of people in developing countries lose their lives due to acute respiratory infections, such as Influenza A & B and Adeno viruses. Given the importance of rapid identification of the virus, in this study the researchers attempted to design a method that enables detection ...  Read More

18. The Evaluation of Diagnostic and Predictive Values of Helicobacter pylori Stool Antigen Test in Iranian Patients with Dyspepsia

Fahimeh Safarnezhad Tameshkel; Mohammad Hadi Karbalaie Niya; Zahedin Kheyri; Davood Azizi; Farzin Roozafzai; Samaneh Khorrami

Volume 13, Issue 1 , Winter 2018, , Pages 39-44


  Background and Objectives: Iran, as a developing country, is experiencing high burdens of Helicobacter pylori (Hp)-associated non-communicable diseases. Hp stool antigen test (HpSA) is widely used as an inexpensive and feasible noninvasive method to diagnose Hp infection, instead of invasive approaches. ...  Read More

19. A Comparative Evaluation of ELISA, PCR, and Serum Agglutination Tests For Diagnosis of Brucella Using Human Serum

Khashayar Mohseni; Reza Mirnejad; Vahab Piranfar; Shiva Mirkalantari

Volume 12, Issue 4 , Autumn 2017, , Pages 371-376


  Background & Objective: Since the symptoms of Brucellosis are often atypical and nonspecific, using clinical signs alone to diagnose brucellosis is not advised; therefore, the diagnosis relies predominantly on laboratory testing. Currently, molecular, serological, and microbiological methods are ...  Read More

20. Frequency of 16S rRNA Methylase and Aminoglycoside-Modifying Enzyme Genes among Clinical Isolates of Acinetobacter baumannii in Iran

Mehrdad Gholami; Mohammadreza Haghshenas; Mona Moshiri; Shbnam Razavi; Abazar Pournajaf; Gholamreza Irajian; Mohsen Heidary

Volume 12, Issue 4 , Autumn 2017, , Pages 329-338


  Background & objective: Multidrug-resistant Acinetobacter baumannii (MDR-AB) is an important nosocomial pathogen which is associated with significant morbidity and mortality, particularly in high-risk populations. Aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (16S rRNA) ...  Read More

21. Bacterial Etiology and Antibiotic Resistance Patterns in Neonatal Sepsis in Tehran during 2006-2014

Fatemeh Haj Ebrahim Tehrani; Mohammad Moradi; Narjes Ghorbani

Volume 12, Issue 4 , Autumn 2017, , Pages 356-361


  Background & Objective: Neonatal sepsis is one of the leading causes of mortality in neonatology wards. The aim of this study was to assess sepsis pathogens and antibacterial resistance patterns in a teaching hospital during seven years in Tehran, Iran. Methods: In this retrospective study, all neonates ...  Read More

22. The Frequency of qnr Genes in Extended-Spectrum β-lactamases and non-ESBLs Klebsiella pneumoniae Species Isolated from Patients in Mashhad, Iran

Nafiseh Izadi; Mahboubeh Naderi Nasab; Elnaz Harifi Mood; Zahra Meshkat

Volume 12, Issue 4 , Autumn 2017, , Pages 377-383


  Background and Objectives: Since the fluoroquinolones are the broad-spectrum antibiotics, they affect both Gram-negative and Gram-positive bacteria. These antibiotics are widely prescribed by physicians. As a result, some bacteria, especially Enterobacteriaceae, have shown a resistance to this family ...  Read More

23. blaVIM and blaIMP Genes Detection in Isolates of Carbapenem Resistant P. aeruginosa of Hospitalized Patients in Two Hospitals in Iran

Behrang Kazeminezhad; Arezoo Bostanmanesh Rad; Atoosa Gharib; Sara Zahedifard

Volume 12, Issue 4 , Autumn 2017, , Pages 392-396


  Background & objective: Beta-lactam antibiotics resistance specifically Imipenem and Meropenem, the last choices of treatment, causes fatal events in patients with P.aeruginosa infection. The aim of this study was to detect the VIM and IMP of metallo-beta-lactamase genes in 103 isolates of P. aeruginosa ...  Read More

24. Comparison of Interferon-Gamma (IFNG) +874 T/A Single Nucleotide Polymorphism in Hepatitis C Virus Infected Patients and Non-Infected Controls in Mashhad, Iran

Sina Rostami; Alireza Pasdar; Sina Gerayli; Hamed Hatami; Samaneh Sepahi; Fatemeh Nategh; Mojtaba Meshkat; Seyed Mousalreza Hoseini; Mitra Ahadi; Hamid Reza Sima; Hasan Vosughinia; Mohammad Reza Sarvghad; Abbas Esmaeelzade; Hosein Nomani; Homan Mosanan Mozafari; Fariba Rezai Talab; Mohammad Taghi Shakeri; Zahra Meshkat

Volume 12, Issue 3 , Summer 2017, , Pages 248-256


  Background and Objectives: Interferon-gamma is an important cytokine, which facilitates immunity against intracellular pathogens. Several factors, including genetic variations of cytokine-producing genes have been shown to influence the progression and severity of Hepatitis C virus (HCV) infection. Methods: ...  Read More

25. Conserved OprF as a Selective Immunogen Against Pseudomonas aeruginosa

Ehsan Kazemi Moghaddam; Parviz Owlia; Abolfazl Jahangiri; Iraj Rasooli; Mohammad Reza Rahbar; Marjan Aghajani

Volume 12, Issue 2 , Spring 2017, , Pages 165-170


  Background & Objectives: Due to the importance of Pseudomonas aeruginosa in severe inpatient infections and high mortality, the need for an efficient vaccine against these bacteria is increasing. In this regard, the general outer membrane porin of the most problematic microorganism P. aeruginosa, ...  Read More