Diagnostic Pathology
sora yaari; Viroj Wiwanitkit
Volume 13, Issue 4 , October 2018, , Pages 479-479
Abstract
Dear Editor, erythrocyte sedimentation rate (ESR) is a useful basic clinical pathology laboratory investigation. It can be helpful in diagnosis and follow-up of several diseases. At present, a new automated method with proven reliability is available for ESR test (1). Here, the authors report on ...
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Dear Editor, erythrocyte sedimentation rate (ESR) is a useful basic clinical pathology laboratory investigation. It can be helpful in diagnosis and follow-up of several diseases. At present, a new automated method with proven reliability is available for ESR test (1). Here, the authors report on observation on a laboratory experiment to test the effect of zinc nanoparticles on ESR results. The total of 100 blood samples was used in the experiment. Each sample was divided into two parts. One part was directly measured for ESR and the other part was added by 1 droplet of zinc nanoparticles solution then exposed to ESR measurement. All ESR measurements were done using the same automated ESR analyzer; MicroSed SR-system, in the same ISO15189 accredited clinical laboratory at the same time, place and condition. The ESR results showed a difference in ESR values between two groups. The ESR values for the groups with and without zinc nanoparticles were equal to 25.6 + 7.2 and 10.7 + 3.4 mm/hr, respectively. Therefore, zinc nanoparticles can interrupt the ESR test conducted by automated analyzer. This observation was similar to the recent report which showed nanoparticles can alter the result of lipid profile test (2). Therefore, due to the widely use of nanoparticle substances, practitioners must consider the effect of nanoparticles interference in the interpretation of ESR results.
Ahmad Talebian; Zarichehr Vakili; Safar Ali Talar; Seyede Mahbobeh Kazemi; Gholam Abbas Mousavi
Volume 4, Issue 4 , September 2009, , Pages 157-160
Abstract
Background and Objectives: Febrile convulsion is one of the most common types of seizure in childhood. Its pathogenesis is unknown, so studying its cause is valuable. The purpose of this study was to determine the serum level of zinc and magnesium in children withfebrileconvulsion (F.C) ...
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Background and Objectives: Febrile convulsion is one of the most common types of seizure in childhood. Its pathogenesis is unknown, so studying its cause is valuable. The purpose of this study was to determine the serum level of zinc and magnesium in children withfebrileconvulsion (F.C) (3 months to 6 years age). Patients and Methods: In this analytical case-control study, serum level of zinc and magnesium in 60 children with F.C in Shahid Beheshty Hospital of Kashan, center of Iran, was determined. The control group was composed of febrile children with no seizure. All children in both groups were 3 months to 6 yr of age and had not any background of disorders. Serum level of zinc & magnesium was determined by biochemical methods in all groups. Finally, the data were analyzed by SPSS and t test. Results: The mean serum level of zinc and magnesium in case group, was lower than that of zinc & magnesium in control group (P<0.05). There was no relationship between sex, type and time of seizure with serum level of zinc or magnesium in children in case group. Conclusion: There was a relationship between serum level of zinc & magnesium and the presence of F.C in children. So, it is suggested to use supplements of zinc and magnesium in diet of affected children for prophylaxis of febrile seizure recurrences.
Foroogh sadat Hashemi; Maryam Abolhasani; Seyed Mohammad Hakimi
Volume 2, Issue 2 , April 2007, , Pages 54-58
Abstract
Introduction and Objective: Zinc as the second trace element of the human body plays an important role in numerous functions. A large number of research studies have showed serum zinc deficiency and excess urinary excretion in patients with major beta thalassemia, but few studies revealed excess urinary ...
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Introduction and Objective: Zinc as the second trace element of the human body plays an important role in numerous functions. A large number of research studies have showed serum zinc deficiency and excess urinary excretion in patients with major beta thalassemia, but few studies revealed excess urinary zinc excretion in minor beta thalassemia and no study investigated serum zinc levels in this group. This study aimed to measure serum and urine zinc level in patients with minor beta thalassemia. Materials and Methods: The study was observational and cross-sectional. Blood and 24-hour urine samples were collected from carriers of beta thalassemia who attended Ali Asghar Hospital for blood transfusions for their children. They had documented hemoglobin electrophoresis for their status. The serum and urine zinc levels were measured by atomic absorption spectrophotometer. Student’s t test was used for comparison of groups. Results: The average level of zinc in the serum and urine of the male cases was 69 ± 10 μg/dl and 714 ± 162 μg/dl and in the female cases was 58 ± 11 μg/dl and 751 ± 162 μg/dl respectively and was 64 ± 12 μg/dl and 730 ± 120 μg/dl totally. The obtained serum zinc was lower and the urine zinc was higher in minor beta thalassemic persons than the amounts mentioned by references for the subjects of the same sex and age. The serum zinc level of anemic patients with minor beta thalassemia was lower (63 ± 11 vs 72 ± 13 μg/dl) and the urine zinc level was higher (792 ± 183 vs 673 ± 202 μg/dl) than non-anemic patients. Conclusion: Minor beta thalassemics have lower serum zinc level and due to abundant roles of zinc can make benefit from zinc supplementation. This decrement may be attributed to tubulopathy in these patients.
