Head and Neck Pathology
Lisnawati Rachmadi; Ela Laelasari; Yayi Dwina Bilianti; Kusmardi Kusmardi
Abstract
Background & Objective: The expression of matrix metalloproteinase-9 (MMP-9) and chemokine receptor 7 (CCR7) is significantly associated with tumor invasion and metastasis. Little is known regarding the potential of these markers in predicting cancer metastasis in Laryngeal Squamous Cell Carcinoma ...
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Background & Objective: The expression of matrix metalloproteinase-9 (MMP-9) and chemokine receptor 7 (CCR7) is significantly associated with tumor invasion and metastasis. Little is known regarding the potential of these markers in predicting cancer metastasis in Laryngeal Squamous Cell Carcinoma (LSCC). Therefore, this study aimed to dissect the potential of these markers in predicting the lymph node metastasis in LSCC patients.Methods: Sixty tissue samples were obtained from the patients diagnosed pathologically with LSCC who underwent partial or total laryngectomy. The expression of MMP-9 and CCR7 was measured using the immunohistochemistry staining in the tissue samples of LSCC patients. The ROC (receiver operating characteristic) curve was used to determine the most significant cut-off points of expression according to the highest sensitivity and specificity of both the markers to predict the lymph node metastasis in LSCC. Then, the relationship between the clinicopathology features and the expression of MMP-9 and CCR7 was evaluated.Results: The expression of both MMP-9 and CCR7 was significantly correlated with the lymph node metastasis in LSCC (P<0.001). Furthermore, CCR7 expression exhibited the highest prediction accuracy (AUC 95.7%) and sensitivity (100%) in predicting the lymph node metastasis in LSCC compared to that of MMP-9 (AUC 92.9%, sensitivity 90%). We also found that patients with larger tumor size (> 4 cm) had significantly higher expression of MMP-9 and CCR7 (P<0.002 and P<0.001, respectively). The Elevated expression level of CCR7 statistically correlated with higher MMP-9 expression (P<0.001).Conclusion: MMP-9 and CCR7 might be beneficial as predictors of lymph node metastasis in LSCC patients.
Head and Neck Pathology
Anjali Mary JIbi; Vijaya Basavaraj
Abstract
Background & Objective: Head and Neck Squamous cell carcinoma (HNSCC) is one of the leading cancers worldwide. Cervical lymph node metastasis is the most adverse prognostic factor for patients with HNSCC. As there are no reliable factors in predicting lymph node metastasis, recent researchers focus ...
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Background & Objective: Head and Neck Squamous cell carcinoma (HNSCC) is one of the leading cancers worldwide. Cervical lymph node metastasis is the most adverse prognostic factor for patients with HNSCC. As there are no reliable factors in predicting lymph node metastasis, recent researchers focus on identifying various metastasis markers that will aid treatment selection. Podoplanin is a recent marker strongly associated with lymph node metastasis, aggressive tumor behavior, and poor prognosis. The expression of podoplanin in human squamous cell cancers and its association with cancer cell motility suggest a possibility that it could be used as a biomarker to predict lymph node metastasis. To study the expression of podoplanin in head and neck squamous cell carcinoma, determine its association with clinicopathological variables, and predict its use as a biomarker in predicting lymph node metastasis.Methods: The present study was conducted in a tertiary care hospital. Podoplanin expression was studied in 45 cases of HNSCC and its association with clinicopathological variables. The predictive power of podoplanin was further analyzed using univariate and multivariate logistic regression analysis. The positive and negative predictive values of podoplanin were determined concerning the presence or absence of lymph node metastasis.Results: Podoplanin expression is significantly associated with histological grade (P=0.03) and lymph node metastasis (P=0.01). In logistic regression analysis, podoplanin expression (Odds Ratio: 5.66, Confidence Interval: 1.23 -25.87, P=0.02) was a significant independent predictor of lymph node metastasis.Conclusion: Our study demonstrates that podoplanin provides prognostic information and predicts lymph node metastasis which was consistent with our studies in the literature. Thus, podoplanin may help better stratify patients selected for elective neck node dissection in early tumor stages and clinically negative regional disease.
Maryam Khalili; Zahra Alyani
Volume 3, Issue 3 , June 2008, , Pages 140-145
Abstract
Background and Objective: Oral cancer accounts for less than 3% of all cancers. Despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. Several studies have been performed to assess factors influencing lymph node metastasis and prognosis. ...
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Background and Objective: Oral cancer accounts for less than 3% of all cancers. Despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. Several studies have been performed to assess factors influencing lymph node metastasis and prognosis. The aim of this study was to evaluate some clinical and pathological factors influencing lymph node metastasis in oral squamous cell carcinoma (SCC). Materials and Methods: In this retrospective study, 111 cases of oral SCC registered from 1991 to 2001 were retrieved from the archive of the Department of Pathology of Cancer Institute. Cases were divided into two groups based on the presence of lymph node metastasis. Patients’ pathological reports and medical records were reviewed and variables such as age, gender, occupation, disease duration, site and greatest diameter of tumor and histopathologic grade were compared between metastatic and non-metastatic groups. Data were analyzed using SPSS package and t, chi square, Mann-Whitney and Fisher’s exact test with pResults: Among the studied factors, patients’ gender (female), the disease duration (more than 12 months) and tumor size based on T1–T4 category were significantly related to lymph node metastasis. Other factors failed to show any correlation with lymph node metastasis. Conclusion: Based on the results of this study, women with large tumors lasting more than 12 months might be of greater risk for lymph node metastasis.