Alireza Abdollahi; Mehrnaz Rasoulinejad; Seyed Jalil Mousavi; Fatemeh Fattahi; Akram Sarbiaei
Volume 4, Issue 3 , June 2009, , Pages 113-117
Abstract
Background and Objective: Brucellosis is a main transmittable zoonotic disease, which is endemic, and a common health burden in Iran. Adenosine deaminase (ADA) is an essential enzyme which is involved in purine metabolism and its role in immune system is very important. The aim of this study ...
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Background and Objective: Brucellosis is a main transmittable zoonotic disease, which is endemic, and a common health burden in Iran. Adenosine deaminase (ADA) is an essential enzyme which is involved in purine metabolism and its role in immune system is very important. The aim of this study was to determine serum changes of ADA and C-reactive protein (CRP) levels in patients with brucellosis. Patients and Methods: The study was a case-control one on 36 patients and 36 controls. The serum level of ADA and quantitative CRP was measured in both patients and controls. We also measured the Wright, Coomb,s Wright and 2-mecapto ethanol (2ME) in two participants groups. Statistical analysis was performed using SPSS for windows Version 11.5 Results: ADA serum level in patients group showed a significant difference compared to control group (31.64±25.1 vs. 13.97±3.9, P<0.0001). Quantitative CRP level in patients group was higher than control group significantly (25 ±20.7 vs 6.9±4.4 , P,s Wright, and 2ME with serum ADA and CRP levels (P=NS). Conclusion: This finding shows the serum level of ADA and CRP are two important parameters in diagnosis, treatment of brucellosis with the considering of the clinical manifestations and other paraclinic findings. However it is advisable to perform more studies.
Abasali Omidi; Amir Hossein Jafarian; Minoo Erfanian; Mohammad Javad Yazdanpanah; Masoud Sharifian
Volume 4, Issue 3 , June 2009, , Pages 133-136
Abstract
Human brucellosis is common in developing countries and is a multi-system disease with a broad spectrum of clinical manifestations. Cutaneous lesions associated with brucellosis have been rarely reported in the literature. Here we present a case of a 32-year-old man with history of consumption ...
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Human brucellosis is common in developing countries and is a multi-system disease with a broad spectrum of clinical manifestations. Cutaneous lesions associated with brucellosis have been rarely reported in the literature. Here we present a case of a 32-year-old man with history of consumption of cheese made from raw milk seen with occurrence of pancytopenia and diffuse maculopapular rash during the course of Brucella infection. Physical examination showed fever, splenomegaly, mild hepatomegaly and pruritic maculopapular exanthema over the trunk, arms and legs. Laboratory tests revealed pancytopenia. Parasitic examinations and serologic tests for syphilis, salmonellosis, rickettsiasis, toxoplasmosis, Epstein-Barr virus, human immunodeficiency virus, and hepatitis B and C viruses were negative. There was no history of drug consumption.The Brucella agglutination test titer was 1/1280 and histological examination of skin biopsy showed lymphohistiocytic perivascular infiltrates in the upper dermis.Lesions were interpreted as Brucellar dermatitis , The patient was subsequently treated with oral doxycycline and rifampin and was discharged in good health. If there is suspicion of exposure to infected food products, brucellosis should be included in the differential diagnosis of pancytopenia in Brucella-endemic areas; there may be skin lesions other than purpura that can accompany thrombocytopenia.
