Shahrzad Hadavand; Fatemeh Ghafoorimehr; Leila Rajabi; Ali Davati; Nafiseh Zafarghandi
Abstract
Background & Objectives: One of the important infectious factors in pregnant mothers and newborns is Group B Streptococcus (GBS). There is no perfect report about prevalence of GBS in Iran and in the case of preterm rupture of amniotic membrane or preterm labor all patients are treated by antibiotics ...
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Background & Objectives: One of the important infectious factors in pregnant mothers and newborns is Group B Streptococcus (GBS). There is no perfect report about prevalence of GBS in Iran and in the case of preterm rupture of amniotic membrane or preterm labor all patients are treated by antibiotics without culture so this has led to adverse taking antibiotics and drug resistance. The present study is intended to determine the frequency of colonization of GBS in the pregnant mother (35-37 weeks), referred to medical centers of Shahed University. Methods: Overall, 210 pregnant women (35-37 weeks), referred to medical center of Shahed University, Tehran, Iran were selected as sample group and after filling out the questionnaires about demographic data and midwifery status and the related information of post- partum, the rectovaginal culture was done for them. Results: Among 210 samples, 7 (3.3%) included positive culture in terms of GBS colonization while all these cases were sensitive to penicillin, ampicillin, cephalothin, nitrofurantoin, and all of the samples were resistant against tetracycline and contrimoxazole. There was no relationship among age, job, education, number of pregnancy, blood pressure background, diabetes and preterm childbirth with positive culture. Similarly, because of limited number of positive cases it was not possible to examine the relationship among GBS colonization and infection in mother and newborn. Conclusion: There was a low frequency in GBS colonization in the studied hospitals and the study inside the country also confirms this finding.
Ahia Garshasbi; Samira Behboudi Gandevani; Soghrat Faghih-Zadeh; Tooba Ghazanfari
Volume 6, Issue 1 , January 2011, , Pages 20-26
Abstract
Background and Objective: Preterm birth occurs in 8% to 11% of all pregnancies and is responsible for 75% to 80% of all neonatal deaths. Cytokines may be involved in the etiology of preterm birth through their stimulation of prostaglandin synthesis. Cytokines may be released intocervicovaginal ...
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Background and Objective: Preterm birth occurs in 8% to 11% of all pregnancies and is responsible for 75% to 80% of all neonatal deaths. Cytokines may be involved in the etiology of preterm birth through their stimulation of prostaglandin synthesis. Cytokines may be released intocervicovaginal fluid during the breakdown of the chorio-decidual adhesion or from an inflammatory reaction in the same area. The aim of this study was to determine whether the values of interleukin 8 and 6 in cervical secretions could predict spontaneous preterm birth in asymptomatic high-risk pregnant women.
Materials and Methods: Levels of interleukin 6 and 8 in cervical samples, collected from 100 pregnant women between 22 to 28 weeks of gestation were measured by ELISA test in Mostafa Khomeini and hazrat-zeinab university hospitals in Tehran, from December 2006 to July 2007. Gestational age at time of delivery was recorded. Receiver operator characteristic curve analysis was used.
Results: There were 4.8, and 4.4, -fold increase in cervical interleukin 8 and 6 concentrations in early preterm versus term delivery. A single interleukin 8 >751.25 pg/ml, and l interleukin 6 >157 pg/ml, was identified early preterm versus term delivery. Sensitivity , specificity, positive and negative predictive values of interleukin 8 in early preterm birth were 89% , 83%, 69% , 94% and for interleukin 6 as 89%, 78%, 63% , 88%, respectively.
Conclusion: Cervical interleukin 8 and 6 is a sensitive and specific predictor preterm delivery.