Oral Pathology
Abbas Karimi; Samira Derakhshan; Monir Moradzadeh Khiavi; Farzaneh Mosavat; Faeze Mirjalili
Abstract
Desmoplastic fibroma (DF) is a benign, locally aggressive neoplasm that rarely occurs in the facial skeleton. It usually presents during the first three decades of life. Due to its aggressiveness and high recurrence rate, early diagnosis is imperative, and complete surgical removal of the lesion is the ...
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Desmoplastic fibroma (DF) is a benign, locally aggressive neoplasm that rarely occurs in the facial skeleton. It usually presents during the first three decades of life. Due to its aggressiveness and high recurrence rate, early diagnosis is imperative, and complete surgical removal of the lesion is the treatment of choice. Herein, we present three cases of DF namely a 2 year-old girl with a mandibular DF, a 9 year-old boy with a maxillary lesion and a 1.5-year old boy with a mandibular DF. Complete clinicopathological information, treatment plan and long-term follow-up of patients are discussed. Histopathologic features of 3 cases revealed non-capsulated spindle cell tumor with fascicular or swirling patterns in incisional biopsy. Immunohistochemical staining was performed to make a definitive diagnosis. Strongly positive nuclear immunoreactivity for β-catenin confirmed the diagnosis of desmoplastic fibroma in 3 cases. Segmental mandibulectomy, partial maxillectomy and hemimandibulectomy were done for the cases. There was no recurrence in our reported cases after 8 and 11 months and 3 years follow up, respectively. It is noteworthy that despite the aggressive nature of DF, young patients often respond well to wide resection treatment.
Gynecologic Pathology
Fatemeh Bagheri; Somayyeh Rahmani; Somayyeh Azimi; Jamileh Bigom Taheri
Abstract
Giant Cell Fibroma (GCF) was described as a new entity of fibrous hyperplastic soft tissue. It seems that stimulus from an unexplained origin can have a role in its etiology. Histopathologically GCF is consisted of multinucleated fibroblasts that have oval shape nuclei within the eosinophilic cytoplasm. ...
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Giant Cell Fibroma (GCF) was described as a new entity of fibrous hyperplastic soft tissue. It seems that stimulus from an unexplained origin can have a role in its etiology. Histopathologically GCF is consisted of multinucleated fibroblasts that have oval shape nuclei within the eosinophilic cytoplasm. Surgical excision is the treatment of choice and recurrence is very rare. Here we report a case of relatively large GCF in a 54-year-old man. Gingiva is the common location of GCF. As in our case, it may be mistaken as irritation fibroma especially if it is on the buccal mucosa, the most common location for fibroma. Correct diagnosis is based on biopsy and clinical examination to see surface texture roughness. To minimize bleeding because of its large size an excisional biopsy with Diod laser was performed under local anesthesia for this patient.
Saeedeh Khajeh Ahmadi; Amin Rahpeyma
Volume 8, Issue 2 , April 2013, , Pages 131-134
Abstract
In 1991, Handlers and colleagues described the Central odontogenic fibroma (COF) as a distinct entity which is a rare benign odontogenic tumour and up to the present, only 78 cases of it have been published. COF usually occurs in an adult patient and has a predilection for the anterior region of the ...
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In 1991, Handlers and colleagues described the Central odontogenic fibroma (COF) as a distinct entity which is a rare benign odontogenic tumour and up to the present, only 78 cases of it have been published. COF usually occurs in an adult patient and has a predilection for the anterior region of the jaws. A 2.8:1 female to mail ratio is typically noted. This article presents a case of COF in a 50-year-old male in the right side of mandible and discuss about the clinic pathological findings, radiographic feature, differential diagnosis, as well as surgical technique of the COF.
Maryam Assadat Hashemi Pour; M Rad; A Mojtahedi
Volume 3, Issue 2 , March 2008, , Pages 81-87
Abstract
Background and Objective: Different mechanisms may lead to the development of soft tissue tumor-like lesions in the oral cavity. Many of these lesions can be identified as specific entities on the basis of their histopathological features and are divided into fibrous, vascular, and giant cell ...
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Background and Objective: Different mechanisms may lead to the development of soft tissue tumor-like lesions in the oral cavity. Many of these lesions can be identified as specific entities on the basis of their histopathological features and are divided into fibrous, vascular, and giant cell types. The purpose of this study was to establish the relative prevalence of the different histopathological aspects of biopsies of oral soft tissue tumor-like lesions at School of Dentistry, Kerman Univ. Med. Sci. Materials and Methods: Documents and records of 260 patients with localized lesions of oral tissues diagnosed from March 1996 to March 2004 were reviewed. The lesions were classified into either fibrous or soft hemorrhagic lesions. Clinical data regarding age, gender, location, and treatment of lesions were obtained for each case. Data included in the present retrospective study were analyzed by SPSS statistical software (13.5) using t- test and chi-square tests. Results: A total of 260 surgical specimens of lesions of the oral cavity presented clinically were studied; 143 cases (55%) had fibrous lesions and 117 cases (45%) had soft hemorrhagic lesions. The fibrous lesions included 91 cases (63.6%) of gingival lesions, whereas 98 cases (83.76%) of the soft hemorrhagic lesions had gingival lesions. The patients were simultaneously treated by excisional biopsy and elimination of the chronic irritant. Conclusion: Oral lesions are often detected by dental professionals, surgeons and ENT specialists. Knowledge of the frequency and presentation of the most common oral lesions is beneficial in developing a clinical impression of such lesions encountered in practice.
