Volume 19 (2024)
Volume 18 (2023)
Volume 17 (2022)
Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Breast Pathology
Comprehensive Analysis of the Prognostic Marker and Immune Infiltrates of LDLR-Related Proteins Family Members in Breast Cancer

Negin Parsamanesh; Shabnam Shahidi; Parvin Ansari Shayesteh; Mahsa Alami

Volume 19, Issue 1 , January 2024, , Pages 31-49

https://doi.org/10.30699/ijp.2023.1995769.3077

Abstract
  Breast cancer is one of the common malignant tumors worldwide accounting for 15% of all cancer-related deaths. Since a timely diagnosis of BC is essential for optimal treatment and also increasing the survival rate of patients. Today, various financial support is applied to find the best biomarkers. ...  Read More

Breast Pathology
Effective Ki-67 Reduction by Short-Term Administration of Letrozole Before Surgery in (Hormone-Positive) Breast Cancer

Bita Eslami; Sadaf Alipour; Farzaneh Golfam; Behnaz Jahanbin; Ramesh Omranipour

Volume 19, Issue 1 , January 2024, , Pages 103-106

https://doi.org/10.30699/ijp.2023.2002772.3118

Abstract
  Background & Objective: Antigen Ki-67 (histone-based nuclear protein) is a static marker of tumor cell proliferation and growth and is commonly measured to indicate the effect of treatment in breast cancer patients. This single-arm trial study aimed to evaluate the effect of short-term endocrine ...  Read More

Breast Pathology
Evaluation of HER2 Positivity Based on Clinicopathological Findings in HER2 Borderline Tumors in Iranian Patients with Breast Cancer

Ramesh Omranipour; Newsha Nazarian; Sadaf Alipour; Alireza Abdollahi; Bita Eslami

Volume 18, Issue 4 , October 2023, , Pages 403-409

https://doi.org/10.30699/ijp.2023.561915.2970

Abstract
  Background & Objective: Human epidermal growth receptor-2 (HER2) gene amplification is an important predictive and prognostic factor in breast cancer treatment. However, the expression of HER2 determined by immunohistochemistry (IHC) is considered as borderline in some cases, and confirmation of ...  Read More

Breast Pathology
Correlation of Before and After Invasive Breast Cancer Neoadjuvant Chemotherapy for NFkB, Cyclin D1, and Survivin Expression

Primariadewi Rustamadji; Elvan Wiyarta; Ineke Anggreani

Volume 18, Issue 2 , April 2023, , Pages 156-164

https://doi.org/10.30699/ijp.2023.562935.2983

Abstract
  Background & Objective: Patients undergoing neoadjuvant chemotherapy (NC) for invasive breast cancer (IBC) therapy need biomarkers to track their progress. Because of the relationship between NFkB, Survivin, and Cyclin D1 with NC resistance, the different expression levels of each of these biomarkers ...  Read More

Breast Pathology
Immunoexpression of the GCDFP-15 Marker in Different Grades of Breast Carcinoma

Faeze Shirian; Parvin Kheradmand; Nastaran Ranjbari; Hodjatollah Shahbazian; Seyed Mahmoud Latifi

Volume 18, Issue 1 , January 2023, , Pages 75-81

https://doi.org/10.30699/ijp.2023.558196.2945

Abstract
  Background & Objective: During the last decade, biological markers of breast cancer have been considered to predict the degree of histology, behavior, and extent of tumor invasion and the possibility of lymph node involvement. The aim of this study was to evaluate the expression of GCDFP-15 in different ...  Read More

Cytology
Evaluation of GATA3 and GCDFP15 Expression in Triple Negative Breast Cancers

Mahsa Ahadi; Afshin Moradi; Elham Rabiee; Fatemeh Pourmotahari

Volume 18, Issue 1 , January 2023, , Pages 90-95

https://doi.org/10.30699/ijp.2023.561917.2969

Abstract
  Background & Objective: Breast cancer is one of the most common cancers in the world. There are some different types of breast cancer and triple-negative breast cancer is the type in which no receptors for estrogen, progesterone, and human epidermal growth factor receptor-2 are expressed. Identifying ...  Read More

Breast Pathology
Exploring the Integrated Role of AKT2, CD44v6, And MT1-MMP as Predictors of Axillary Lymph Node Metastasis in Invasive Breast Carcinoma of No Special Type

Primariadewi Rustamadji; Elvan Wiyarta; Kristina Anna Bethania

Volume 17, Issue 4 , October 2022, , Pages 475-485

https://doi.org/10.30699/ijp.2022.551244.2866

Abstract
  Background & Objective: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer, which mainly causes axillary lymph-node metastasis (ALNM). Building on our previous research, we wanted to explore the optimal combination of AKT2, CD44v6, and MT1-MMP for the ...  Read More

Breast Pathology
Apoptosis Induction, Cell Cycle Arrest and Anti-Cancer Potential of Tamoxifen-Curcumin Loaded Niosomes Against MCF-7 Cancer Cells

Mahdi Fatemizadeh; Farzaneh Tafvizi; Farzaneh Shamsi; Sahar Amiri; Afsaneh Farajzadeh; Iman Akbarzadeh

Volume 17, Issue 2 , April 2022, , Pages 183-190

https://doi.org/10.30699/ijp.2022.124340.2358

Abstract
  Background & Objective: Breast cancer is the most common cancer among women. One of the most effective treatments for breast cancer is chemotherapy, in which specific drugs destroy the mass and its proliferation is inhibited. Chemotherapy is the most effective adjunctive therapy when multiple medications ...  Read More

Breast Pathology
A Novel Subset of Triple-Negative Breast Cancers with Unique Histology and Immunohistochemical Expression

Swaminathan Kalyanasundaram; Shantaraman Kalyanaraman; Hidhaya Kaleelullah Fathima; Vidhya Mohan; Kavitha Selvaraj

Volume 17, Issue 2 , April 2022, , Pages 217-224

https://doi.org/10.30699/ijp.2022.139734.2526

Abstract
  Background & Objective: Triple-Negative Breast Carcinoma (TNBC) is characterized by an absence of estrogen receptor, progesterone receptor and HER2 neu expression, with distinct molecular, histological and clinical features, aggressive clinical course and a poor prognosis. The objective was to evaluate ...  Read More

Breast Pathology
Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer

Armin Borhan; Zohreh Nozarian; Alireza Abdollahi; Reza Shahsiah; Hadiseh Mohammadpour; Arash Borhan

Volume 16, Issue 1 , January 2021, , Pages 27-32

https://doi.org/10.30699/ijp.2020.121532.2322

Abstract
  Background & Objective: Nowadays, actin-binding proteins such as Villin and Gelsolin have been considered to be associated with aggressive tumors. This study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients with ...  Read More

Molecular Pathology
Variants of Genes Involved in Metabolism of Folate among Patients with Breast Cancer: Association of TYMS 3R Allele with Susceptibility to Breast Cancer and Metastasis

Zohreh Rahimi; Maryam Bozorgi Zarini Bozorgi Zarini; Ziba Rahimi; Ebrahim Shakiba; Asad Vaisi-Raygani; Mohammad Taher Moradi; Kheirolah Yari

Volume 16, Issue 1 , January 2021, , Pages 62-68

https://doi.org/10.30699/ijp.2020.117676.2283

Abstract
  Background & Objective: Breast cancer (BC) is known to be the most prevalent cancer among women. One-carbon metabolism (OCM) disturbance might play an important role in the etiology of BC. The present study aimed to investigate the thymidylate synthase (TYMS), 5-methyltetrahydrofolate-homocysteine ...  Read More

Gynecologic Pathology
Predicting Effects of Clinicopathological Variables on Her2 Gene Amplification by Chromogenic in situ Hybridization (CISH) in IHC Her2 (2+) Breast Cancer Patients; A Study from Iran

Mohammad Hashemi-Bahremani; Abdolali Ebrahimi; Mohaddese Fallahi

Volume 15, Issue 3 , July 2020, , Pages 217-224

https://doi.org/10.30699/ijp.2020.110293.2172

Abstract
  Background & Objective: The her2 amplification plays an important role in breast cancer management. Therefore, there is a need for using supplementary molecular methods in IHC equivocal cases. Present study has been conducted to determine the effects of clinicopathological variables on her2 gene ...  Read More

Breast Pathology
The Difference of Expression of 18 Genes in Axillary Invasion and Vascular Invasion Compared to Control Samples in Breast Cancer

Alireza Abdollahi; Sepideh Jahanian; Nima Hemmati; Hadiseh Mohammadpour

Volume 14, Issue 3 , August 2019, , Pages 223-231

https://doi.org/10.30699/ijp.2019.92094.1894

Abstract
  Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess ...  Read More

Breast Pathology
Vascular Mimicry Expression in Invasive Ductal Carcinoma; A New Technique for Prospect of Aggressiveness

Amir Hosein Jafarian; Melika Kooshkiforooshani; Abdolshakor Rasoliostadi; Nema Mohamadian Roshan

Volume 14, Issue 3 , August 2019, , Pages 232-235

https://doi.org/10.30699/ijp.2019.94997.1939

Abstract
  Background & Objective: In vascular (vasculogenic) mimicry (VM), tumoral cells mimic the endothelial cells and form the extracellular matrix-rich tubular networks. It has been proposed that VM is more extensive in aggressive tumors. This study was designed to investigate the rate of VM expression ...  Read More

Clinical Value of Serum S100A8/A9 and CA15-3 in the Diagnosis of Breast Cancer

Samaneh Khorrami; Masoumeh Tavakoli; Elahe Safari

Volume 14, Issue 2 , April 2019, , Pages 104-112

https://doi.org/10.30699/ijp.14.2.104

Abstract
  Background and Objective: S100A8/A9 is a heterodimer calcium-binding protein which is involved in tumor cell proliferation, adhesion and invasion, and is proposed as a biomarker for better diagnosis and prognosis in many cancers. The aim of this study was to evaluate the simultaneous serum-based level ...  Read More

Biology & Genetic
Relationship Between PIK3CA Amplification and P110α and CD34 Tissue Expression as Angiogenesis Markers in Iranian Women with Sporadic Breast Cancer

Shadi Hosseini; Farkhondeh Behjati; Maryam Rahimi; Nazanin Taheri; Hamid Reza Khorram Khorshid; Fatemehte Aghakhani Moghaddam; Saghar Ghasemi Frouzabadi; Masoud Karimlou; Fereidoon Sirati; Elahe Keyhani

Volume 13, Issue 4 , October 2018, , Pages 447-453

Abstract
  Background and Objective: The PI3K/AKT/mTOR pathway is known to play an important role in regulating angiogenesis both in normal and breast cancer (BC) tissues. PIK3CA amplification was reported in various malignancies, including approximately 10% of BC cases. The aim of this study was to identify the ...  Read More

Tissue Expression of Prohibition-I and Its Relationship With Prognostic Factors in Breast Cancer

Hossein Javid; Isaac Hashemy; Soudabeh Shahid sales; Nema Mohammadian Roshan; Tayyebeh Kianoosh; Farnaz Zahedi Avval

Volume 13, Issue 2 , April 2018, , Pages 237-244

https://doi.org/10.30699/ijp.13.2.237

Abstract
  Background & objective: Globally, breast cancer is the most common malignancy among females. Prohibition (PHB)-I, a homologous protein, was initially introduced as a suppressor gene for amplification process. Further, the protein has a key role in the cell cycle and is capable of inhibiting ...  Read More

Hematopathology
Prognostic Significance of Reduction in Ki67 Index After Neoadjuvant Chemotherapy in Patients With Breast Cancer in Kerman Between 2009 And 2014

Vahid Moazed; Elham Jafari; Behjat Kalantari khandani; Ali Nemati; seyedamir benrazavi

Volume 13, Issue 1 , January 2018, , Pages 71-77

https://doi.org/10.30699/ijp.13.1.71

Abstract
  Background and objective:Breast cancer is the most common malignancy among women. The Neoadjuvant chemotherapy is the treatment of choice for non-operable tumors. The Ki67 is a proliferation marker that can be used to predict the therapeutic response to chemotherapy and the patients' prognosis. Methods: ...  Read More

The Core Needle and Surgical Biopsy Concordance to Detect Estrogen, Progesterone, and Her-2 Receptors in Breast Cancer: A Comparative Study

Fereshteh Ensani; Ramesh Omranipour; Isa Jahanzad; Azadeh Jafari; Shima Nafarzadeh; Pouyan Aminishakib

Volume 12, Issue 3 , July 2017, , Pages 202-208

https://doi.org/10.30699/ijp.2017.25042

Abstract
  Background &Objectives: Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented. ...  Read More

High Expression of Sphingosine Kinase 1 in Estrogen and Progesterone Receptors-Negative Breast Cancer

Azadeh Sadat Nazouri; omolbanin asadpour; Shahriar Dabiri; Bahram Pourseyedi; Mohamad reza Lashkarizadeh; Hamid Zeinalyneghad

Volume 12, Issue 3 , July 2017, , Pages 218-224

https://doi.org/10.30699/ijp.2017.25049

Abstract
  Background & objective: Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell ...  Read More

Hematopathology
Chromogenic in situ Hybridization Compared with Real Time Quantitative Polymerase Chain Reaction to Evaluate HER2/neu Status in Breast Cancer

Hossein Ayatollahi; Azar Fani; Ehsan Ghayoor Karimiani; Fateme Homaee; Arezoo Shajiei; Maryam Sheikh; Sepideh Shakeri; Seyyede Fatemeh Shams

Volume 12, Issue 2 , April 2017, , Pages 128-134

https://doi.org/10.30699/ijp.2017.24870

Abstract
  Background and objective: The assessment of human epidermal growth factor receptor 2 (HER2) status has become of great importance in the diagnosis of breast cancer. The aim of this study was to investigate the diagnostic value of quantitative Polymerase Chain Reaction (qPCR) and Chromogenic In Situ Hybridization ...  Read More

Biochemistry
Effect of Silibinin on Maspin and ERα Gene Expression in MCF-7 Human Breast Cancer Cell Line

Maryam Karimi; Hossein Babaahmadi-Rezaei; Ghorban Mohammadzadeh; Mohammad-Ali Ghaffari

Volume 12, Issue 2 , April 2017, , Pages 135-143

https://doi.org/10.30699/ijp.2017.24871

Abstract
  Background and objective: According to reports, a serine protease inhibitor (Maspin) suppresses metastasis, invasion and angiogenesis in breast and prostate cancers. Silibinin is a natural polyphenolic flavonoid with anti-cancer activity. We assessed the effects of silibinin on cell viability, maspin ...  Read More

Hematopathology
Fluorescent in Situ Hybridization and Real-Time Quantitative Polymerase Chain Reaction to Evaluate HER-2/neu Status in Breast Cancer

Fatemeh Homaei Shandiz; Azar Fani; Sepideh Shakeri; Maryam Sheikhi; Abouzar Ramezani Farkhani; Arezoo Shajiei; Hossein Ayatollahi

Volume 12, Issue 1 , January 2017, , Pages 67-73

https://doi.org/10.30699/ijp.2017.24228

Abstract
  Background:Breast cancer remains the most common and second lethal cancer in females. HER-2/neu is one of the most important amplified oncogene in breast cancer. The amplification of HER-2 is correlated with decreased survival, metastasis, and early recurrence.  The amplification of HER-2/neu gene ...  Read More

Hematopathology
Jaw Pain as a First Presentation in the Diagnosis of Breast Cancer

Payam Azadeh; Nasser Rakhashni; Ali Yaghobi Joybari; Pegah Gorji Bayani; Samaneh Sarbaz; Maryam Farasatinasab

Volume 11, Issue 5 , October 2016, , Pages 439-442

Abstract
  The oral cavity is uncommon site for metastatic disease usually discovered secondary to malignancy. We encountered with a rare case in which metastasis to mandibular bone was the first clinical sign in the diagnosis of breast cancer without any radiographic findings. A 49-yr-old premenopausal woman, ...  Read More

Biology & Genetic
Maspin Gene Expression in Invasive Ductal Carcinoma of Breast

Shahriar Dabiri; Mohammadmehdi Moeini aghtaei; Jahanbano Shahryari; Manzume Shamis meymandi; Sahar Amirpour-Rostami; Reza Foutohi-Ardekani

Volume 11, Issue 2 , April 2016, , Pages 104-111

Abstract
  Background: The breast cancer is the most prevalent cancer among women, on the other hand absence of myoepithelial cells play a pivotal role in pathogenesis of this cancer. Thus we aimed to investigate the possible abilities of the molecular assay technique to find a relationship between mammary serine ...  Read More