Biochemistry
Mohammad Mahdi Zamani; Seyedeh Hamideh Mortazavi; Maryam Monajemzade; Vahhab Piranfar; Zahra Aalidaeijavadi; Azam Bakhtiarian
Abstract
Background and Objective: Increased industrial activities leads to prolonged human exposure to industrial pollutant such as cadmium (Cd). Chronic exposure to Cd in Mammals and also human being, can cause damages to various organs and particularly kidneys and liver. The goal of this study was to ...
Read More
Background and Objective: Increased industrial activities leads to prolonged human exposure to industrial pollutant such as cadmium (Cd). Chronic exposure to Cd in Mammals and also human being, can cause damages to various organs and particularly kidneys and liver. The goal of this study was to investigate the prophylactic effects of combined selenium (Se) and ascorbic acid supplement in rat cadmium toxicity. Methods: Sixty adult male Wistar rats were divided into 10 groups: one control, one sham, and two clusters of 4 intervention groups which were fed with 1 or 5 mg Cd /kg water, for 28 days. The ascorbic acid supplement was added to the drinking water of four groups (10 mg/l). Four groups received intraperitoneal Se (1 mg/kg) at day 1, 5, 10, 15, 20, and 25. Finally, Cd concentration was measured by atomic absorption spectrophotometry in liver and kidney sections. Furthermore, pathological changes were investigated in these sections. Results: The results showed weight gain in Cd groups which received ascorbic acid and Se, in contrast to weight loss in parallel groups without vitamin C and Se. The stronger necrosis and inflammation have been observed in group received 5 mg/kg Cd compared to group with 1 mg/kg Cd (p <0.05). In addition, the cadmium level was higher in untreated groups without any supplements, significantly (p <0.05). Conclusion: The drinking water with ascorbic acid has prophylactic effects across cadmium, and combination of Se and ascorbic acid have more prophylactic effects in both kidney and liver of rat to decrease the Cd toxicity.
Uropathology
Bita Geramizadeh; Nadereh Shams; Pouya Iranpour; Mohammad javad Rajabi
Abstract
Renal hemangioma is a rare tumor which can be capillary or cavernous. There have been less than 30 renal capillary hemangioma cases reported in the English literature. Herein we will report a case of renal hemangioma which was detected in a 74-year-old man operated with the impression of urothelial ...
Read More
Renal hemangioma is a rare tumor which can be capillary or cavernous. There have been less than 30 renal capillary hemangioma cases reported in the English literature. Herein we will report a case of renal hemangioma which was detected in a 74-year-old man operated with the impression of urothelial carcinoma of hilum.
Uropathology
Omid Azari; Reza Kheirandish; Mohammad Farajli Abbasi; Shahin Ghahramani Gareh Chaman; Masoud Bidi
Abstract
Background: Renal ischemia reperfusion injury may occur in a variety of clinical situations, following a transient drop in total or regional blood flow to the kidney. This study was performed to investigate the protective effects of different antioxidants such as vitamin C, vitamin E, hydrocortisone ...
Read More
Background: Renal ischemia reperfusion injury may occur in a variety of clinical situations, following a transient drop in total or regional blood flow to the kidney. This study was performed to investigate the protective effects of different antioxidants such as vitamin C, vitamin E, hydrocortisone and combination of these agents against experimental renal ischemia-reperfusion injury.
Method:Thirty male rats were divided into six groups. Group Sham, Group I/R: (45 min of ischemia followed by 1h of reperfusion), Group I/R+Vit C: (50 mg/kg Vit C, IV, immediately after reperfusion), Group I/R+Vit E: (20 mg/kg Vit E, IM, 15 min before reperfusion), Group I/R+Hydrocortisone: (50 mg/kg, IV, immediately after reperfusion), and Group Combination: Ischemia-reperfusion plus combination of Vit C, E and hydrocortisone. After the experiments, the left kidney was removed and the tissues were processed for histopathological examination.
Result: Severe injuries such as necrosis of tubules, atrophy of glomerulus, and hemorrhage were observed in group I/R. Histological scores indicating tissue injury significantly decreased in all treatment groups compared to the group I/R. The renal tissue in group treatment was preserved in comparison with the group I/R. Comparison between the treatment groups showed that group combination was more effective and group vit E was less effective in protecting of renal tissue against I/R injuries.
Conclusion: The results demonstrated simultaneous administration of combination of Vit C, E and hydrocortisone before reperfusion of blood flow to the ischemic tissue could show a synergy against deleterious effects of I/R injuries in kidney.
Nahid Kazemzadeh; Alireza Kadkhodaei; Babak Soltani; Siamak Soltani; Sahar Rismantab Sani
Volume 9, Issue 3 , July 2014, , Pages 181-186
Abstract
Background & Objectives: Respiratory, central nervous system, and skin complications of mustard gas toxicity have previously been studied; however, the liver and kidney side effects due to this intoxication have not been fully noted. We aimed to evaluate the frequency of liver, kidney and lung lesions ...
Read More
Background & Objectives: Respiratory, central nervous system, and skin complications of mustard gas toxicity have previously been studied; however, the liver and kidney side effects due to this intoxication have not been fully noted. We aimed to evaluate the frequency of liver, kidney and lung lesions in mustard gas-exposed Iranian veterans who had been exposed to the toxin almost 2 decades before.
Methods: A total of 100 veteran bodies underwent autopsy by at least two forensic medicine specialists. The liver, kidney and lung specimens were sent for pathological examination and their lesions, severity of the lesions, and the relation between the type/severity of the lesions and the time elapsed since their appearance were studied.
Results: A total of 83%, 63%, and 62% of the veterans had lung, liver, and kidney pathologies. The most common pathologies included liver steatosis, interstitial fibrosis of the kidney, and lung atelectasis.
Conclusion: Liver and kidney pathologies are far more common than what is considered in the mustard gas-exposed veterans. These pathologies are often accompanied by very severe lung complications.
Amir Hossein Jafarian; Abbas Ali Omidi; Ali Shamsa; Saeedeh Khajeh Ahmadi
Volume 8, Issue 2 , April 2013, , Pages 123-126
Abstract
Primitive neuroectodermal tumor (PENETs) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. In more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). Immunohistochemical staining may be required for diagnosis of PENET. The ...
Read More
Primitive neuroectodermal tumor (PENETs) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. In more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). Immunohistochemical staining may be required for diagnosis of PENET. The cells of tumor express CD99, vimentin, NSE, FL1 but do not express Ck, LCA, myogenin, and WT1. We present a 36-year –old female with left –side tender abdominal swelling, and history of trauma to abdominal. CT imaging confirmed a huge solid mass of kidney, also extending into renal pelvis. Histological section of the lesion showed a malignant proliferation of small round cells in rosette-like pattern with foci of necrosis area. Tumor cells expressed high level of CD 99 antigen. The diagnosis of the lesion was primitive neuroectodermal tumors (PNET). Following-up after 6 months showed no recurrence.
Indranil Chakrabarti; Anuradha De; Amita Giri
Volume 6, Issue 3 , June 2011, , Pages 147-152
Abstract
Primitive neuroectodermal tumor (PNET) of kidney is an extremely rare renal neoplasm with only about fifty reported cases in literature. Presumably,of neural crest origin, these tumors behave aggressively and ...
Read More
Primitive neuroectodermal tumor (PNET) of kidney is an extremely rare renal neoplasm with only about fifty reported cases in literature. Presumably,of neural crest origin, these tumors behave aggressively and carry a poor prognosis. We report a case of 22-year old female patient complaining of left loin pain with recurrent hematuria for last 3 months. On clinical examination, the abdomen was soft and no palpable mass was felt. She underwent ultrasonography and com puted tomography, which revealed a left renal mass. A left radical nephrectomy was performed. Histopathological examination of the nephrectomy specimen showed features of primitive neu roectodermal tumor arising from left kidney, which was confirmed by immunohistochemistry (IHC). The patient was treated with post-nephrectomy chemotherapy and was symptom-free at six-month follow-up.
Roohollah Gholampour-Shahabodini; Behrang Kazemjnejad
Volume 5, Issue 3 , June 2010, , Pages 154-157
Abstract
Primary sarcomas of the kidney are exceptional. Among renal sarcomas, leiomyosarcoma is the most common histologic subtype amounting to 50-60% of all cases. The tumor usually arises from either the renal capsule or smooth muscle tissue in the renal pelvic wall. In this paper, we report a patient ...
Read More
Primary sarcomas of the kidney are exceptional. Among renal sarcomas, leiomyosarcoma is the most common histologic subtype amounting to 50-60% of all cases. The tumor usually arises from either the renal capsule or smooth muscle tissue in the renal pelvic wall. In this paper, we report a patient with leiomyosarcoma of the kidney presented with non-specific abdominal pain and a palpable mass. Histologic examination revealed a mesenchymal tumor composed of pleomorphic spindle cells arranged in interlacing pattern with high mitotic activity. Immunohistochemical study was positive for Demin, smooth muscle Actin (SMA), and muscle specific antigen (MSA).The rarity of this disease and very little information about it, its severity, and poor prognosis, uncommon form of presentation, large size of the mass, and difficulty in management are highlighted and reported.
Bijan Rezakhaniha; Soheila Sirosbakhtv
Volume 5, Issue 1 , January 2010, , Pages 47-50
Abstract
Human echinococcosis remains a complex problem that affects several organs. Hydatid disease mainly (85%) affects liver as well as lung, and 10% the rest of the body. Renal involvement is about 2% while skin hydatidosis is nearly 1%. Coincidental involvement of kidney and skin is very rare. We ...
Read More
Human echinococcosis remains a complex problem that affects several organs. Hydatid disease mainly (85%) affects liver as well as lung, and 10% the rest of the body. Renal involvement is about 2% while skin hydatidosis is nearly 1%. Coincidental involvement of kidney and skin is very rare. We report a 51 year-old female patient with renal and skin (chest wall) hydatid lesions that were excised radically and the diagnosis of hydatidosis was confirmed histologically in EMAM REZA Hospital, Tehran in 2007. For treatment albendazol 400 mg BID was chosen, followed by monthly inspection of liver and CBC control up to six months. The case did not show any sign of recurrence in 24 months of following up.