Seyed Hassan Hosseini Hooshyar; Hamid Zeinalinejad; Mehran Mosallami; Shahriar Dabiri; Jahanbanoo Shahryari; Moeinadin Safavi
Volume 8, Issue 4 , October 2013, , Pages 267-272
Abstract
We present unusual retained remnants of hidden conjoined twin of possible abdominal pagus after 21 years who presented with abdomenpain and incidentally have found his forbidden conjoined twin. He presented for many years with a palpable epigastric mass, and recent abdominal pain, early satiety, nausea ...
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We present unusual retained remnants of hidden conjoined twin of possible abdominal pagus after 21 years who presented with abdomenpain and incidentally have found his forbidden conjoined twin. He presented for many years with a palpable epigastric mass, and recent abdominal pain, early satiety, nausea and vomiting. The mass was a like deformed fetus weighing 815 gr who was anencephalic and deprived of viscera but there was a distinct vascular connection through the rig limb. Microscopic examination revealed a normal epidermis with melanocytes overlying dermis with mature adnexa. The fetus plain film after surgery showed a rather complete skeletal system. All above findings were in favor of fetus in fetus, a rare congenital entity in which a nonviable parasitic fetus grows within the body of its twin.
Masomeh Bayani; Sepideh Siadati; Seddigheh Esmaeilzadeh; Samaneh Asgari; Saeed Salmani
Volume 8, Issue 3 , July 2013, , Pages 171-177
Abstract
Background and Objectives: Chicken pox has potential complications during pregnancy for both the mother and her baby. The aim of this study was to determine the Varicella-zoster virus (VZV) immune status in pregnant women in Babol and its surrounding neighborhoods.
Materials and Methods: This seroepidemiological ...
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Background and Objectives: Chicken pox has potential complications during pregnancy for both the mother and her baby. The aim of this study was to determine the Varicella-zoster virus (VZV) immune status in pregnant women in Babol and its surrounding neighborhoods.
Materials and Methods: This seroepidemiological study was carried out on 427 pregnant women referred to Rohani Hospital, Babol, northern Iran from 2010 to 2011. The immune status (IgG level) was determined using ELISA method and correlation with age, place of residence, history of VZV infection and the number of siblings were evaluated.
Results: The mean age of the subjects was 27.16 + 5.7 years and their mean antibody level was 103.552 + 63.37 U/ml. Out of 427 pregnant women studied, 8.7% were seronegative, 1.2% were equivocal and 90.2% were seropositive. There was no correlation between age, the place of residence (urban or rural) and titer of antibody. However, higher antibody titer was found in women with more siblings.
Conclusion: Considering 90.2% of pregnant women were VZV seropositive, evaluation of VZV antibody in order to prevent complications in non-immune pregnant women and vaccination for women with age less than 25 years old and no VZV infection history, prior to pregnancy is recommended.
Hamzeali Hamzeali
Volume 8, Issue 2 , April 2013, , Pages 89-96
Abstract
Background and Objective: Since it is essential for the research policy makers to acquire knowledge about the global ranks of their countries in in Pathology and Forensic Medicine subject areas, scientometrics experts have been always ranking and analyzing countries on the basis of ‘total number ...
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Background and Objective: Since it is essential for the research policy makers to acquire knowledge about the global ranks of their countries in in Pathology and Forensic Medicine subject areas, scientometrics experts have been always ranking and analyzing countries on the basis of ‘total number of papers’, ‘total number of citations’ and ‘citations per paper’, etc.
Materials and Methods: The data in SCImago[1] has been used to analyze and evaluate the global ranks of Iran, Turkey, Saudi Arabia, India, Pakistan, South Korea and South Africa. These countries had a similar growth trend in many indicators of science and technology in the past.
Results: This article mainly deals with the extent of presence of these countries in Pathology and Forensic Medicine subject areas, their international global ranks and comparing them with each other. Furthermore, data show that these countries had a different situation considering “citations per Document”; because it did not match with their “number of Document” and “total number of citations” to their papers and did not increase accordingly. “Citations per Document” is considered as one of the most important indicators which show the average number of citations to each document.
Conclusion: The situation of Iran under the study seemed to be better in some areas such as ‘Cite per Documents’ than their situation in other areas; however, this point should be taken into consideration that they did not have an equal presence in all areas.
[1] The SCImago Journal & Country Rank is a portal that includes the journals and country scientific indicators developed from the information contained in the Scopus database
Amir Hossein Jafarian; Abbas Ali Omidi; Ali Shamsa; Saeedeh Khajeh Ahmadi
Volume 8, Issue 2 , April 2013, , Pages 123-126
Abstract
Primitive neuroectodermal tumor (PENETs) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. In more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). Immunohistochemical staining may be required for diagnosis of PENET. The ...
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Primitive neuroectodermal tumor (PENETs) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. In more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). Immunohistochemical staining may be required for diagnosis of PENET. The cells of tumor express CD99, vimentin, NSE, FL1 but do not express Ck, LCA, myogenin, and WT1. We present a 36-year –old female with left –side tender abdominal swelling, and history of trauma to abdominal. CT imaging confirmed a huge solid mass of kidney, also extending into renal pelvis. Histological section of the lesion showed a malignant proliferation of small round cells in rosette-like pattern with foci of necrosis area. Tumor cells expressed high level of CD 99 antigen. The diagnosis of the lesion was primitive neuroectodermal tumors (PNET). Following-up after 6 months showed no recurrence.
Alireza Monsef; Mahmood Farshchian; Mohammad Jafari; Mehdi Farshchian
Volume 7, Issue 4 , September 2012, , Pages 231-235
Abstract
Background & Objective: Autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. Autoantibodies are against the intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis ...
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Background & Objective: Autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. Autoantibodies are against the intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis bullosa aquisita. The tissue-bound and circulating serum autoantibodies can be detected with direct immunofluorescence (DIF) and indirect Immunofluorescence (IIF) tests. The aim of this study was to pinpoint the immunofluorescence pattern of Iranian patients with autoimmune bullous diseases.
Methods: In a prospective case series study, sixteen patients with autoimmune disease enrolled in the study for two years. Perilesional skins and sera from the patients were used in DIF and IIF for detection of immunofluorescence pattern.
Results:Out of 16 cases, 9 cases had pemphigus and 7 cases had bullous pemphigoid. All cases of pemphigus had positive DIF in intercellular region with lacelike pattern; IgG was detected in all cases, IgA in 1(11.1%) case and C3 in 3 (33.3%) cases. One (11.1%) case of pemphigus had positive IIF in intercellular region with lacelike pattern; circulating autoantibodies were IgG and IgA. All cases of bullous pemphigiod had positive DIF in dermal-epidermal Junction with linear pattern. IgG was detected in all cases, IgM in one (14.3%) case, and C3 in six (85.7%) cases. One (14.3%) case of bullous pemphoid had positive IIF in dermal-epidermal Junction with linear pattern; circulating autoantibody was IgG.
Conclusion: Immunofluorescence tests are sensitive diagnostic methods for autoimmune bullous diseases. IIF positive cases in our study were lower compared to the previous reports.
Sepideh Siadati; Seyed Reza Modares
Volume 7, Issue 4 , September 2012, , Pages 256-258
Abstract
Bronchogenic cyst is a result of abnormal development of the ventral foregut presents as a discrete mass. Most commonly, it is appeared in the middle mediastinum and rarely is seen in adults. We report a 35-year-old woman who was asymptomatic and incidentally was found with a mass in chest ...
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Bronchogenic cyst is a result of abnormal development of the ventral foregut presents as a discrete mass. Most commonly, it is appeared in the middle mediastinum and rarely is seen in adults. We report a 35-year-old woman who was asymptomatic and incidentally was found with a mass in chest radiograph.
Tahereh Mirzaei; Hossein Hooshyar
Volume 7, Issue 4 , September 2012, , Pages 259-261
Abstract
Hydatid disease, caused by larval stage of Echinococcus granulosus, is a common parasitic infection of human and animal. Although liver and lung are the most commonly affected area, hydatid cyst may develop any part of the body. Primary subcutaneous hydatid cyst is extremely rare. We report a case of ...
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Hydatid disease, caused by larval stage of Echinococcus granulosus, is a common parasitic infection of human and animal. Although liver and lung are the most commonly affected area, hydatid cyst may develop any part of the body. Primary subcutaneous hydatid cyst is extremely rare. We report a case of 54 years old man who presented with palpable mass in scapular region from 3 years ago. Present and past medical history was not significant finding. Pathologic evaluation identified the cystic structure as unilocular hydatid cyst. Primary hydatid disease constitutes a potentially serious differential diagnosis of any subcutaneous mass in endemic area of hydatid disease.
Hamid Galehdari; Raheleh Tangestani
Volume 7, Issue 4 , September 2012, , Pages 262-266
Abstract
Wilson disease is a metabolic disorder with an autosomal recessive genetic pattern and occurs in 1-4 of every 100000 individuals. Inactivation of the ATP7B gene leads to accumulation of the toxic copper to liver and brain causing hepatic and neurological complication. Therefore, most patients suffer ...
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Wilson disease is a metabolic disorder with an autosomal recessive genetic pattern and occurs in 1-4 of every 100000 individuals. Inactivation of the ATP7B gene leads to accumulation of the toxic copper to liver and brain causing hepatic and neurological complication. Therefore, most patients suffer from chronic hepatic inflammation and central nervous system disorder. Nowadays, up to 500 mutations were found in the ATP7B gene that weaken or fully disrupt the function of the gene product. Recurrent mutations were found in different population. We found a homozygous pathogenic missense mutation at codon 778 (R778W) in an individual from southwest Iran. This mutation has been reported in previous studies in the continents America and Europe. The present study is the first report from Wilson disease that has been diagnosed in southwest Iran. This mutation has been shown in previous studies in patients from continents America and Europe.
Ali Eslamifar; Amitis Ramezani; Mohammad Banifazl; Akbar Khadem-Sadegh; Arezoo Aghakhani
Volume 7, Issue 3 , July 2012, , Pages 171-176
Abstract
Background and Aims: Pertussis is a highly contagious, vaccine-preventable disease. Determination of the seroepidemiology of pertussis makes possible the evaluation of pertussis immunity in a population. In this study, we determined the seroprevalence of Bordetella pertussis IgG antibodies in different ...
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Background and Aims: Pertussis is a highly contagious, vaccine-preventable disease. Determination of the seroepidemiology of pertussis makes possible the evaluation of pertussis immunity in a population. In this study, we determined the seroprevalence of Bordetella pertussis IgG antibodies in different age groups in Tehran, Iran.
Materials and Methods: Overall, 1101 subjects between ages of 8 months and 20 years were tested for the presence of pertussis toxin (PT), filamentous hemagglutinin (FHA) and different lipopolysaccharides (LPS) antibodies by ELISA.
Results: The overall prevalence of pertussis antibodies was 48% and the mean antibody level was 44± 47.7 U/ml. Over half (53.1%) of the children aged 8 months to 6 years were negative for pertussis antibodies. Pertussis antibodies rates and levels were significantly different between age groups (P < 0.001) and their significant elevations were observed with increasing age.
Conclusion: Up to half of the vaccinated children lacked an antibody response to vaccine, so using a more immunogenically effective vaccine to ensure sufficient immunity is essential. We showed that B. pertussis infection is on the rise in Iranian adolescents and young adults. Booster vaccination of this age group appears to be the most logical approach to disease prevention in adolescents and control the circulation of the organism.
Ali Zare Mirzaie; Maryam Abolhasani; Roozbeh Mobasher Moghaddam; Maryam Kadivar
Volume 7, Issue 3 , July 2012, , Pages 183-189
Abstract
Background and Objectives: Gastrointestinal polyps are proliferative or neoplastic mucosal lesions. The most important point about these polyps is risk of malignancy of them. This study was performed to determine type and frequency of polyps of gastrointestinal tract in Iranian population according to ...
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Background and Objectives: Gastrointestinal polyps are proliferative or neoplastic mucosal lesions. The most important point about these polyps is risk of malignancy of them. This study was performed to determine type and frequency of polyps of gastrointestinal tract in Iranian population according to their locations.
Materials and Methods: Totally, 210 patients referred to Rasul-e-Akram Hospital in years 2006-2010 and had pathology report of gastrointestinal polyps were included in the study. Frequency of gastrointestinal polyps was determined according to type, histological subtype, location, age and sex. The data was analyzed by software SPSS 16.
Results: Of participants, 129 patients were male (61.4%) and 81 (38.6%) were female. The mean age of patients was 58.4±32 yr. The mode of age interval was 70-80 yr (25.2%). The most frequent presenting symptom was lower gastrointestinal bleeding as melena or hematochesia (31%). Colon and sigmoid were site of most of gastrointestinal polyps (74.2%). The most prevalent type of gastrointestinal polyps was adenomatous polyp which was reported in 175 patients (84.3%). The most common types of colonic and gastric polyps were adenomatous and hyperplastic types respectively.
Conclusion: Our data is highly confirmatory to previous studies regarding association of polyp with advanced age and male sex, the most prevalent symptom and site of gastrointestinal polyps, and the most common types of colonic polyps. The frequency of gastric polyps in our population differs with some studies.
Abolfazl Khoshdel; Shahla Taheri; Reza Khadivi; Ebrahim Saedi; Kurosh Ashrafi; Reza Imani; Faranak Jazaeri
Volume 7, Issue 2 , April 2012, , Pages 86-91
Abstract
Background and Objective: In Iran, prenatal Chlamydia and gonorrhea screening of pregnant women and neonatal eye prophylaxis are not routine practice. The present research aimed to identify bacterial agents of neonatal conjunctivitis.
Materials & Methods: A cross sectional study was conducted on ...
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Background and Objective: In Iran, prenatal Chlamydia and gonorrhea screening of pregnant women and neonatal eye prophylaxis are not routine practice. The present research aimed to identify bacterial agents of neonatal conjunctivitis.
Materials & Methods: A cross sectional study was conducted on all babies born over a period from April 2007 to April 2008 in Hajar Hospital of Shahrekord University of Medical Sciences. Babies presenting clinical signs of erythema and edema of eyelid and purulent eye discharge were considered as clinical conjunctivitis. Specimens were obtained in all cases with conjunctivitis and were performed gram staining and cultures in specific media. A simple ELISA has been performed for measurement the immunoglobin M antibody to C. trachomatis and positive result rechecked by indirect immunoflurescent test.
Results: During the period of one year, 223 neonates have revealed bacterial conjunctivitis. The incidence rate of neonatal conjunctivitis was 2.8%. Chlamydia conjunctivitis was identified in 13.6% of cases and gonococcal conjunctivitis was identified in 5.5% of cases.
Discussion: The high incidence rate of Chlamydia and gonococcal conjunctivitis, have revealed that the eye prophylaxis from ophthalmia neonatorum is needed promptly.
Hamid Tabrizchee; Armita Esmaili
Volume 6, Issue 4 , September 2011, , Pages 193-201
Abstract
Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic ...
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Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. Materials and Methods: We included 61 cases diagnosed as CHL, ALCL, and anaplastic variant of DLBCL. We reviewed morphologic microscopic findings by conventional staining and immunohistochemistry (IHC) with antibodies against PAX-5, CD30, CD15, CD45, EMA, ALK-1, and LMP-1. Results: Fifty cases corresponded to CHL (81.97%), 4 cases to ALCL (6.56%), and 4 cases to DLBCL (6.56%) excluding 3 cases, which remained unclassifiable (4.92%). PAX-5 was expressed in 94% of CHL and 100% of DLBCL cases. LMP-1 was expressed in 52% of CHL and 25% of DLBCL cases. EMA was invariably expressed in all 4 cases of ALK+ALCL. It was expressed in 4/50 cases (8%) of CHL and in 2/4 cases (50%) of DLBCL. CD45 was expressed in all cases of ALCL and DLBCL but also in 3/50 cases (6%) of CHL. Conclusion: The differentiation between ALCL and CHL based on EMA and CD45 is not reliable. Utilization of PAX-5 in combination with other markers such as CD15 and LMP-1 is recommended. CD20 and PAX-5 are not too helpful in the differentiation of CHL and DLBCL, while CD15 and CD79a were found to be quite useful discriminative markers for this purpose.
Mahshid Talebi –Taher; Seied Ali Javad–Moosavi; Alireza Sadeghi-pour; Shokofeh Hadj-sadeghi
Volume 6, Issue 4 , September 2011, , Pages 219-223
Abstract
Hydatid disease is endemic in some parts of the world. This disease can occur in any organ. We present a 22-year-old farmer who was suffering from hydatidosis for 4 years. He was admitted to the hospital because of fever, cough, and chest pain in 2004. A chest radiograph revealed multiple nodules ...
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Hydatid disease is endemic in some parts of the world. This disease can occur in any organ. We present a 22-year-old farmer who was suffering from hydatidosis for 4 years. He was admitted to the hospital because of fever, cough, and chest pain in 2004. A chest radiograph revealed multiple nodules in both of lungs. A transthoracic echocardiogram showed cystic lesion in the apex of right ventricle. IgG Ab ELISA for hydatid cyst was positive and albendazole was administrated. One year later, he was admitted to the hospital because of hemoptysis, a transthoracic lung biopsy was performed. Pathologic examination revealed laminated membrane of hydatid cyst in associated with fibrinoleukocytic exudates. Three years after the second admission, he was admitted to the hospital because of dyspnea. Iranian people especially who live in village need more information about the routes of prevention because therapy is difficult in some cases.
Fahimeh Asadi Amoli; Masoumeh Mohebbi; Amir Hossein Sina
Volume 6, Issue 4 , September 2011, , Pages 224-228
Abstract
Chloroma or granulocytic sarcoma (GS) is a malignant neoplasm of myeloid lineage that occur in a variety of anatomic sites other than the bone marrow including soft tissue, bone, lymph node, nasal fossa, skin and sometime in the orbit. In the subconjunctiva it is rarely reported. A 4-year-old ...
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Chloroma or granulocytic sarcoma (GS) is a malignant neoplasm of myeloid lineage that occur in a variety of anatomic sites other than the bone marrow including soft tissue, bone, lymph node, nasal fossa, skin and sometime in the orbit. In the subconjunctiva it is rarely reported. A 4-year-old girl with a history of treated acute myelogenous leukemia was referred to Farabi Eye Hospital, Tehran, Iran for the evaluation of subconjunctival mass that was appeared since one month ago. Cell blood count (CBC) of the patient was normal except for Hb=7gm/dl. General physical examination was normal except for the signs of anemia. Histopathological evaluation of subconjunctival mass showed a malignant large round cell neoplasm. Immunohistochemical studies confirmed granulocytic sarcoma. When confronting a large cell or undifferentiated round cell neoplasm, the possibility of myeloid sarcoma should be investigated. Myeloperoxidase (MPO), cluster designation (CD) molecules such as CD34, CD45, CD15, CD68 and lysozyme positivity or Leder staining are useful in this regard.
Reza Shafiei; Zahra Riazi; Mohamdreza Sarvghad; Mysam Galian Sharifdini; Abbas Mahmoodzadeh; Massoud Hajia
Volume 6, Issue 2 , April 2011, , Pages 68-72
Abstract
Background and Objectives: Toxoplasmosis has become one of the more frequent opportunistic infections and the most common cause of focal brain lesions complicating the course of AIDS. However, there is a little information about the frequency of the toxoplasmosis in various regions of Iran. At ...
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Background and Objectives: Toxoplasmosis has become one of the more frequent opportunistic infections and the most common cause of focal brain lesions complicating the course of AIDS. However, there is a little information about the frequency of the toxoplasmosis in various regions of Iran. At the present study, we evaluated the prevalence of toxoplasmosis in patients with AIDS in Mashhasd (Northeast Iran). Material and Methods: Overall, 258 suspected patients with CD4+ T-cell count and clinical manifestation for HIV infection were referred from Infectious Disease Center to Imam Reza Hospital in 2009. These patients were examined by ELISA, western blot method and tested by P24 antigen. HIV positive patients (n=121) were entered in this cross-sectional study and investigated for IgG and IgM anti- Toxoplasma antibodies with ELISA. Results: The mean age of the patients was 35.83 + 6.75 yr. 83.5% of the patients were intravenous drug misuse. The IgG anti-Toxoplasma antibodies were positive in 46 (38.01%) patients, while IgM antibody was detected in 3 cases (2.5%). Conclusion: The rate of toxoplasmosis infection in HIV positive patients is high. Therefore, immediate treatment of these patients is essential in rising specific antibody cases that may cause toxoplasmic encephalitis resulting from its reactivation.
Hiva Saffar; Afsaneh Rajabiani; Naser Kamalian
Volume 6, Issue 1 , January 2011, , Pages 36-40
Abstract
Clear cell variant of ependymoma is almost exclusively located in the supratentorial region. Only few cases of this tumor that located in the spinal cord have been reported. Here we report one case of intramedullary clear cell ependymoma of the lumbar spinal cord. In microscopic examination, ...
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Clear cell variant of ependymoma is almost exclusively located in the supratentorial region. Only few cases of this tumor that located in the spinal cord have been reported. Here we report one case of intramedullary clear cell ependymoma of the lumbar spinal cord. In microscopic examination, the tumor cells were round to oval with moderate amounts of clear cytoplasm and centrally located large nuclei, resembling oligodendroglioma. Typical features of ependymoma, such as ependymal clefts, perivascular pseudorosettes, as well as nuclear pseudoinclusions and grooves were identified. Albeit being rare, clear cell ependymoma could be mentioned in differential diagnosis of clear cell tumors in this area.
Hossein Ayatollahi; Akbar Safaei; Mohammad Vasei
Volume 5, Issue 3 , June 2010, , Pages 121-126
Abstract
Background and Objectives: Primary amenorrhea is not a disease but a symptom that may result from several quite different causes[NN1] . Common hormonal cause of primary amenorrhea includes constitutional delay, hypothalamic –pituitary dysfunction, chronic systemic disease and absent ...
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Background and Objectives: Primary amenorrhea is not a disease but a symptom that may result from several quite different causes[NN1] . Common hormonal cause of primary amenorrhea includes constitutional delay, hypothalamic –pituitary dysfunction, chronic systemic disease and absent ovarian function. The aim of this study was to estimate the incidence of the chromosomal abnormality referred for karyotyping in patients with primary amenorrhea in southwest of Iran. Material and Methods: Chromosomal analysis was carried out in 220 such cases that were referred from different parts of the south of Iran. The standard protocol for peripheral blood lymphocyte culture was followed for metaphase chromosome preparation and conventional analysis of G-banded chromosome. Results: The frequency of abnormal karyotypes was 20% in primary amenorrhea. The chromosomal abnormalities can be classified into five main types with or without mosaicism. 1-The most frequent karyotype was X chromosome aneuploidies (10%,n=22) 2-Male karyotype 46, XY was present in 5.5 % (n=12). 3-Structural anomalies of the X chromosome were detected in 3.2% (n=7) . 4-Mosaicism of male chromosome constitution and X chromosome aneuploidy was present in two (0.9%) cases (45XO/46XY). 5-Mosaicism of X chromosome aneuploidy and structural anomalies of X chromosome was found in one (0.45%) case [45, X/46X, i (Xq)]. Conclusion: The present study has emphasized that karyotyping is necessary in evaluation of primary amenorrhea. This study also revealed the incidence of chromosomal abnormalities in women with primary amenorrhea in southwest of Iran is similar to that reported in previous literatures. [NN1]File Format: PDF/Adobe Acrobat - Quick View by SК Ten - 1990 - Cited by 5 - Related articles Primary amenorrhea is not a disease but a symptom that may result from several quite different causes. These include such conditions as endocrinological ... smj.sma.org.sg/3104/3104a13.pdf - Similar
Maliheh Arab; Mohammad Hashemi; Nadereh Masoumi; Mehdi Yaseri; Farzaneh Golfam; Mojgan Ebrahimi
Volume 5, Issue 3 , June 2010, , Pages 132-136
Abstract
Background and Objective: Ovarian tumors are among the most frequent pathologic conditions in gynecologic practice and a frequent cause of hospitalization and surgery. The aim of this study was to determine histologic distribution of benign operated masses especially functional ovarian cysts. ...
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Background and Objective: Ovarian tumors are among the most frequent pathologic conditions in gynecologic practice and a frequent cause of hospitalization and surgery. The aim of this study was to determine histologic distribution of benign operated masses especially functional ovarian cysts. Material and Methods: Benign ovarian files of operated patients (2961 cases) in 20 tertiary and secondary hospitals were reviewed regarding age and histopathology from 1998- 2005. Analysis was done by SPSS software (version 13). Results: The most common benign histologies in order of frequency were functional cyst (57%), serous cystadenoma (13%), dermoid cyst (10%), mucinous cystadenoma (7%) and endometrioma (6%). Conclusion: Functional cysts were the most common benign ovarian cyst. Nearly high distribution of functional cysts in the present study may be an index of need to management improvement and less surgical decisions in ovarian tumors.
Hedieh Moradi Tabriz; Alireza Abdollahi; Saeideh Mahfoozi
Volume 5, Issue 3 , June 2010, , Pages 143-149
Abstract
Background and Objectives: Blood stream infections cause significant morbidity and mortality in the world. In this study, we aimed at describing the organisms responsible for septicemia in 2006-2007 and their antimicrobial susceptibility that might lead to proper selection of antimicrobial agents ...
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Background and Objectives: Blood stream infections cause significant morbidity and mortality in the world. In this study, we aimed at describing the organisms responsible for septicemia in 2006-2007 and their antimicrobial susceptibility that might lead to proper selection of antimicrobial agents in hospitalized patients with suspected sepsis. Materials and Methods: Microbiology reports of 1753 blood specimens collected from inpatients of a referral hospital in Iran were retrospectively reviewed. Specimen culture, bacterial identification, and disk diffusion susceptibility testing were performed according to The Clinical and Laboratory Standards Institute guidelines. Data were analyzed by SPSS, X² Test and the fisher exact Test. Results: Coagulase-negative Staphylococci accounted for most isolated bacteria (24.61%), in both genders. The second and third most frequent isolated bacteria in adults were staphylococcus aureus and Stenotrophomonas maltophilia, and in children were Klebsiella pneumoniae and S. aureus. Among the all Gram – positive cocci, vancomycin was the most effective agent. The most effective antibiotic varied among the Gram-Negative isolates, for example 95.65% of S. maltophilia were susceptible to co-Trimoxazole, and amikacin were suitable antibiotic in 85.29% of E. coli. Conclusion: As the degree of antibiotic resistance rate for blood stream pathogens is alarming, it is mandatory to monitor the susceptibility of these isolates in order to avoid inappropriate use of antibiotics in hospital wards
Roohollah Gholampour-Shahabodini; Behrang Kazemjnejad
Volume 5, Issue 3 , June 2010, , Pages 154-157
Abstract
Primary sarcomas of the kidney are exceptional. Among renal sarcomas, leiomyosarcoma is the most common histologic subtype amounting to 50-60% of all cases. The tumor usually arises from either the renal capsule or smooth muscle tissue in the renal pelvic wall. In this paper, we report a patient ...
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Primary sarcomas of the kidney are exceptional. Among renal sarcomas, leiomyosarcoma is the most common histologic subtype amounting to 50-60% of all cases. The tumor usually arises from either the renal capsule or smooth muscle tissue in the renal pelvic wall. In this paper, we report a patient with leiomyosarcoma of the kidney presented with non-specific abdominal pain and a palpable mass. Histologic examination revealed a mesenchymal tumor composed of pleomorphic spindle cells arranged in interlacing pattern with high mitotic activity. Immunohistochemical study was positive for Demin, smooth muscle Actin (SMA), and muscle specific antigen (MSA).The rarity of this disease and very little information about it, its severity, and poor prognosis, uncommon form of presentation, large size of the mass, and difficulty in management are highlighted and reported.
Mitra Heidarpour; Farzaneh Sajjadi; Seyed Abass Tabatabai; Majid Heidarpour
Volume 5, Issue 3 , June 2010, , Pages 158-162
Abstract
Gardner's syndrome is an autosomal dominant inherited disorder. Familial polyposis of the colon, osteomas, hypertrophy of the retinal-pigmented layer and a multitude of soft tissue tumors are characteristic features. The syndrome may be presented with colonic or extracolonic symptoms. A 75-year-old ...
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Gardner's syndrome is an autosomal dominant inherited disorder. Familial polyposis of the colon, osteomas, hypertrophy of the retinal-pigmented layer and a multitude of soft tissue tumors are characteristic features. The syndrome may be presented with colonic or extracolonic symptoms. A 75-year-old male patient presented to Al-zahra Clinic with diffuse abdominal pain. An abdominal surgery was performed on him due to invasive abdominal mass. The surgical specimen was examined by H&E and immunohistochemical staining. The final diagnosis was fibromatosis. There was a history of gardner’s syndrome in his family. Colonoscopy was done to confirm the diagnosis of gardner’s syndrome. The diagnosis of gardner’s syndrome was made according to following findings: abdominal fibromatosis, multiple jaw osteomas and polyposis coli. The patient with gardner’s syndrome can present with abdominal fibromatosis even in an old age. In IHC staining CD117 was seen with coarse granular cytoplasmic pattern in fibromatosis, and so, this pattern of CD117 staining can be a clue to the diagnosis of fibromatosis.
Younes Roohani; Mohammad Reza Hosseinzadeh; Mahmoodreza Khalatbari; Alireza Sadeghipoor; Farid Zaeri; Azimi-Khatibani , Esmail
Volume 5, Issue 2 , March 2010, , Pages 77-82
Abstract
Background and Objectives: Gliomas are the most prevalent primary brain tumors. The purpose of this retrospective cohort study was evaluation of clinical trend and prognosis of patients with brain glioma and effective factors in prognosis. Materials and Methods: Hundred and forty-five patients ...
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Background and Objectives: Gliomas are the most prevalent primary brain tumors. The purpose of this retrospective cohort study was evaluation of clinical trend and prognosis of patients with brain glioma and effective factors in prognosis. Materials and Methods: Hundred and forty-five patients with supratentorial brain glioma, treated in Shahid Mostafa Khomeini & Hazrat-e-Rasool hospitals in Tehran , Iran from March 1999 to August 2005, were studied. Clinical, therapeutic and malignancy grade data were collected. The WHO classification was used for reporting malignancy grade. All patients were pursued until August 2005. Mann-Whitney, Kaplan-Meier, Cox Regression, and Chi-Square test were used for analysis. Results: Median survival was 39.7 weeks for malignancy grade IV. One-year survival rates in malignancy grades of II, III, IV and all patients were 86%, 83%, 40% and 47%, respectively. In multivariate analysis, effective factors in prognosis of all patients above 60 were radiotherapy and malignancy grade IV; and in patients with malignant glioma were age of above 60 and radiotherapy; and in patients with low-grade glioma were motor deficits. Conclusions: Survival rate decreases from malignancy grade II to IV and this reduction is evident in malignancy grade IV. Role of radiotherapy as an effective factor in prognosis in all patients and in malignant glioma is important.
Mohammad Rahbar; Hadi Mehragan; Negar Haji Ali Akbari
Volume 5, Issue 2 , March 2010, , Pages 90-96
Abstract
Background and Objectives: Non-fementer gram-negative bacilli (NFGB) are ubiquitous pathogen that has emerged as a major cause of health care associated infections. The aim of this study was to determine the prevalence and antimicrobial susceptibility of NFGB in an Iranian hospital. ...
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Background and Objectives: Non-fementer gram-negative bacilli (NFGB) are ubiquitous pathogen that has emerged as a major cause of health care associated infections. The aim of this study was to determine the prevalence and antimicrobial susceptibility of NFGB in an Iranian hospital. Materials and Methods: FromJuly 2005 to November 2006 a total of 257 strains of NFGB including 109 (42.41%) strains of Pseudomonas aeruoginosa, 88 (34.24%) strains of Acinetobacter baumannii, 48 (18.67%) stains of Stenotrophomonas maltophilia and 12 (4.66%) strains of Burkholderia cepacia were isolated from clinical specimens taken from patients hospitalized in an Iranian 1000–bed tertiary care hospital[d1] . Conventional bacteriological methods were used for identification and susceptibility testing of NFGB. Susceptibility testing was performed by method as recommended by Clinical Laboratory Standard Institute (CLSI). Data were analyzed using SPSS 11.5 for Windows (SPSS Inc., Chicago, IL) Results: A total of 257 non-duplicating of NFGB strains were isolated from 234 hospitalized patients. The most effective antibiotic against P. aeruginosa and A. baumannii was imipenem followed by tobramycin. Fluoroquinolones had moderate activity against P. aerugunosa. Most isolates of A.baumannii were multi-drug resistant. Susceptibility of S. maltophila to ticarcillin- clavuanic, ofloxacin and ceftazidim was 96%, 94% and 81%, respectively. Thirty three percent of this bacterium isolates were resistant to co-trimoxazole. Conclusion: In our study, imipenem was the most effective antibiotic against P. aeruginosa and A. baummannii isolates. Previous history use of antibiotics, longer duration of hospital stay and mechanical ventilation were the major risk factors for resistance acquisition in NFGB especially in P. aeruginosa and A. baumannii.
Amit Agrawal; Arvind Bhake; Nisha Meshram; Nisha c
Volume 5, Issue 2 , March 2010, , Pages 97-99
Abstract
Ancient schwannomas rarely found in the central nervous system and ancient change in an intracranial schwannoma (intracranial portion of the trigeminal nerve) is extremely rare. A seventy-year man presented with headache of 3 months duration and one episode of generalized tonic-clonic seizures. ...
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Ancient schwannomas rarely found in the central nervous system and ancient change in an intracranial schwannoma (intracranial portion of the trigeminal nerve) is extremely rare. A seventy-year man presented with headache of 3 months duration and one episode of generalized tonic-clonic seizures. Imaging findings were suggestive of left temporal high grade lesion. During surgery there was well capsulated extra-axial lesion. Histology was suggestive of ancient schwannoma. Based on the literature it is suggested when the intraoperative appearance of a cerebello-pontine lesion is consistent with a schwannoma and the frozen section is suggestive of a malignant lesion, a complete excision of the lesion can be carried out.
Zohreh Yousefi; Shohreh Saeed; Nourieh Sharifi
Volume 5, Issue 2 , March 2010, , Pages 105-108
Abstract
Placental site trophoblastic tumor (PSTT) is the rare variant of gestational trophoblastic diseases (GTD), which differs histologically and immunologically from GTD. Diagnosis of PSTT is often difficult and delayed. In most cases, diagnosis is not possible until the surgery is performed. The ...
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Placental site trophoblastic tumor (PSTT) is the rare variant of gestational trophoblastic diseases (GTD), which differs histologically and immunologically from GTD. Diagnosis of PSTT is often difficult and delayed. In most cases, diagnosis is not possible until the surgery is performed. The most therapeutic choice is hysterectomy and it is usually successful. Here we report two cases of PSTT.