Biology & Genetic
Meysam Rezaeishahmirzadi; Neda Motamedi Rad; Mehdi Kalantar; Hossein Ayatollahi; Sepideh shakeri; Maryam Sheikhi; Mohammad Shekari
Abstract
Background and Objective: The current study aimed at assessing the relationship between gastritis and peptic ulcer susceptibility and inflammation-related gene polymorphisms in Iranian patients. Gastritis and peptic ulcer are common medical complications with serious outcomes on the quality of life. ...
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Background and Objective: The current study aimed at assessing the relationship between gastritis and peptic ulcer susceptibility and inflammation-related gene polymorphisms in Iranian patients. Gastritis and peptic ulcer are common medical complications with serious outcomes on the quality of life. Inflammatory responses of gastric mucosa are associated with helicobacter pylori, but most infected patients remain asymptomatic. There is strong evidence that inflammatory response is a major part of its etiology. Methods: The current case-control study aimed at examining genetic polymorphisms in inflammatory cytokines interleukin (IL)-4, and IL-10 using polymerase chain reaction-variable number tandem reaped (PCR-VNTR) and PCR-restriction fragment length polymorphism (RFLP) methods, respectively in 603 genotyped patients admitted to Mohammadi Hospital in Bandar Abbas, Iran (198 patients with gastritis, 84 with peptic ulcer, and 321 patients as controls). Results: No significant associations were detected in genotype and allele frequencies of IL-10 and IL-4 between the case (with gastritis and peptic ulcer) and control groups. Conclusion: In conclusion, the results of the analyses suggested that these polymorphisms may not predispose the carriers to gastritis and peptic ulcer development.
Alireza Abdollahi; Farid Azmoudeh Ardalan; Hossein Foroutan; Firouzeh Moradkarami
Volume 3, Issue 1 , January 2008, , Pages 35-39
Abstract
Background and Objective: Long period risk of gastric carcinoma in people affected with chronic Helicobacter pylori gastritis is 5 times more than normal people. Perhaps histological changes due to helicobacter pylori infection could be used for screening people at risk of gastric carcinoma and ...
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Background and Objective: Long period risk of gastric carcinoma in people affected with chronic Helicobacter pylori gastritis is 5 times more than normal people. Perhaps histological changes due to helicobacter pylori infection could be used for screening people at risk of gastric carcinoma and peptic ulcer. Materials and Methods: This study has been carried out as a cross-sectional process and we compared histological changes observed in Helicobacter pylori chronic gastritis in 30 patients with peptic ulcer and 30 patients without the ulcer and then classified them according to Sydney scoring system, and after collecting data, we analyzed them by SPSS software. Results: Sixty percent of patients with ulcer were male and forty percent were female. In addition, 56.7% of patients without ulcer were male and 43/3% were female without a statistically significant difference (p = 0.793). Mean age in ulcer group was 56.4 years and in non-ulcer group was 48.9 years that there was no significant statistical difference (p = 0.057). Chronic gastritis frequency increases within people in their sixth decade and after that. There was no significant difference for degree of infection with Helicobacter pylori (p = 0.346), metaplasia (p =0.885), chronicity (p = 0.796) and degree of activity (p = 0.249), atrophy (p = 0.781) in patients with or without ulcer. Conclusion: There was no significant difference in any of the variables of the study including degree of infection with Helicobacter pylori, chronicity, disease activity and intestinal metaplasia between both groups with and without peptic ulcer.