Katayoun Ziari; Mojgan Sanjari; Moeinadin Safavi
Abstract
Background & objective: papillary thyroid cancer is the most common cancer of thyroid accounting for 75%-85% of all thyroid malignancies. Recently, β-catenin has been determined to play a role in clinical course of human epithelial cancers. This study was designed to reveal the association of ...
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Background & objective: papillary thyroid cancer is the most common cancer of thyroid accounting for 75%-85% of all thyroid malignancies. Recently, β-catenin has been determined to play a role in clinical course of human epithelial cancers. This study was designed to reveal the association of β-catenin marker and papillary thyroid carcinoma behavior. Methods: 63 paraffin blocks of papillary thyroid carcinoma were stained with ready to use monoclonal β-catenin antibody according to manufacturer’s instructions. Memberanous, cytoplasmic and nuclear staining was scored according to intensity of immunoreactivity. β-catenin immunostaining association with clinical parameters like number of recurrences and cumulative dose of radioiodine therapy were analyzed using SPSS version 15. Histopathologic parameters like tumor stage, grade, capsular invasion, lymphovascular invasion, lymph node involvement, distant metastasis and other variables were also evaluated for association with β-catenin immunoreactivity Results: 77.8% of papillay thyroid carcinoma were well differentiated and the remaining were poorly differentiated. Loss of β-catenin membrane immunostaining depicted correlation with number of recurrences (p=0.023% , Pearson correlation= -0.285). Its loss of memberanous staining correlated similarly with cumulative dose of radioiodine (p= 0.046, Pearson correlation = -0.253). Loss of membranous β-catenin was significantly associated with some histopathologic findings like nodal involvement (p<0.001), distant metastasis (p=0.003) and tumor dedifferentiation (p< 0.001). Conclusion: Loss of β-catenin membranous staining and its cytoplasmic accumulation were associated with aggressive clinicopathologic behavior. The exact effect of radioiodine exposure on β-catenin pathway remained to be determined in future.
Katayoun Ziari; Kamyab Alizadeh
Volume 11, Issue 5 , October 2016, , Pages 461-464
Abstract
Salivary gland choristoma of the middle ear cavity is a very rare condition. These lesions are a result of a defective embryonic development and their adjacent structures may be associated with abnormalities. Here we report a case of salivary gland choristoma of the middle ear who presented to Be’sat ...
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Salivary gland choristoma of the middle ear cavity is a very rare condition. These lesions are a result of a defective embryonic development and their adjacent structures may be associated with abnormalities. Here we report a case of salivary gland choristoma of the middle ear who presented to Be’sat Hospital, Tehran, Iran in 2015 with unilateral conductive hearing loss. There are 41 case reports in English and non-English literature from 1961. Taylor and Martin reported the first case of middle ear salivary choristoma.
Katayoun Ziari; Kamyab Alizadeh
Volume 11, Issue 1 , January 2016, , Pages 61-65
Abstract
Ovarian hemangiomas are benign and rare tumors of female genital tract with less than 60 reported cases in the literature. A 38- yr- old woman was admitted to Be’sat Hospital, Tehran, Iran in 2012, due to severe abdominal pain. Ultrasound evaluation revealed a 6 cm left ovarian cystic mass and ...
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Ovarian hemangiomas are benign and rare tumors of female genital tract with less than 60 reported cases in the literature. A 38- yr- old woman was admitted to Be’sat Hospital, Tehran, Iran in 2012, due to severe abdominal pain. Ultrasound evaluation revealed a 6 cm left ovarian cystic mass and serum tumor markers were normal. Then, left salpingo-oophorectomy was performed for the patient. Microscopic examination revealed a follicular cyst and an incidental cavernous hemangioma consisting thin-walled vascular channels filled with blood that lined with flatten endothelial cells. In IHC staining strong immunoreactivity for CD31 and CD34 were seen, finally, the diagnosis of primary ovarian hemangioma, cavernous-type was made. The clinicopathologic presentation of this unusual benign tumor is discussed.
Katayoun Ziari; Kamyab Alizadeh; Omid Rahmani; Mohammad-Reza Kazemi
Volume 9, Issue 2 , April 2014, , Pages 160-168
Abstract
Lymphomatous involvement of the appendix is rare and most of them are found accidentally from appendectomies to treat appendicitis. Here we report three cases of primary lymphoma of appendix of 10 year-old boy, 23-year-old man and 24-year-old woman that presented with abdominal pain to our hospital and ...
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Lymphomatous involvement of the appendix is rare and most of them are found accidentally from appendectomies to treat appendicitis. Here we report three cases of primary lymphoma of appendix of 10 year-old boy, 23-year-old man and 24-year-old woman that presented with abdominal pain to our hospital and the tumors were discovered during routine appendectomy for suspected "appendicitis". Our cases underwent chemotherapy regimen and they were asymptomatic respectively at 14, 17, and 18 months following-up. In the literature review of the tumors of the appendix, most of the begin tumors of appendix are treated with surgery alone. Lymphoma requires CHOP-like chemotherapy and carcinoid tumor treated according to the size of the tumor <2 with appendectomy alone and >2 with right hemicolectomy. The preferred treatment for adenocarcinoma of appendix is right hemicolectomy and the role of chemotherapy is unclear but when lymph node involvement is present, chemotherapy seems to be accepted.