Alireza Abdollahi; Mehrnaz Rasoulinejad; Seyed Jalil Mousavi; Fatemeh Fattahi; Akram Sarbiaei
Volume 4, Issue 3 , June 2009, , Pages 113-117
Abstract
Background and Objective: Brucellosis is a main transmittable zoonotic disease, which is endemic, and a common health burden in Iran. Adenosine deaminase (ADA) is an essential enzyme which is involved in purine metabolism and its role in immune system is very important. The aim of this study ...
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Background and Objective: Brucellosis is a main transmittable zoonotic disease, which is endemic, and a common health burden in Iran. Adenosine deaminase (ADA) is an essential enzyme which is involved in purine metabolism and its role in immune system is very important. The aim of this study was to determine serum changes of ADA and C-reactive protein (CRP) levels in patients with brucellosis. Patients and Methods: The study was a case-control one on 36 patients and 36 controls. The serum level of ADA and quantitative CRP was measured in both patients and controls. We also measured the Wright, Coomb,s Wright and 2-mecapto ethanol (2ME) in two participants groups. Statistical analysis was performed using SPSS for windows Version 11.5 Results: ADA serum level in patients group showed a significant difference compared to control group (31.64±25.1 vs. 13.97±3.9, P<0.0001). Quantitative CRP level in patients group was higher than control group significantly (25 ±20.7 vs 6.9±4.4 , P,s Wright, and 2ME with serum ADA and CRP levels (P=NS). Conclusion: This finding shows the serum level of ADA and CRP are two important parameters in diagnosis, treatment of brucellosis with the considering of the clinical manifestations and other paraclinic findings. However it is advisable to perform more studies.
Alireza Abdollahi; Sedighe Borna; Fatemeh Mirzaei; Akram Sarbiaei
Volume 4, Issue 1 , January 2009, , Pages 5-8
Abstract
Background and Objectives: Preterm labor is a serious problem in obstetrics, accounting for 70% of perinatal mortality. High sensitive C - reactive protein (HS-CRP) is a sensitive marker of Inflammation. Our aim in this study was to determine Amniotic fluid hs-CRP concentration and its correlation ...
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Background and Objectives: Preterm labor is a serious problem in obstetrics, accounting for 70% of perinatal mortality. High sensitive C - reactive protein (HS-CRP) is a sensitive marker of Inflammation. Our aim in this study was to determine Amniotic fluid hs-CRP concentration and its correlation with pre-Term delivery. Materials and methods: This prospective study was conducted on 90 pregnant women who underwent genetic amniocentesis between the 15th and 20th weeks of gestation. All patients were followed until delivery. Pateints with abnormal karyotype and iatrogenic preterm delivery for fetal and maternal indications were excluded. The samples were carried immediately to the laboratory of Imam Khomaini Hospital Complex, Tehran, Iran for cytogenetic examination and tested for HS-CRP by turbidimetric method. Non parametric tests and receiver-operating characteristics curve analysis were used for statistical purpose. Results: The study showed no correlation between amniotic fluid HS-CRP concentrations with preterm delivery. Maternal serum alpha-fetoprotein (AFP) levels were higher in patients delivered preterm compared with term deliveries (P=0.036). Conclusion: Our results implicated that HS-CRP like other acute phase response markers was not as a possible risk marker of preterm delivery.