Mitra Heidarpour; Farzaneh Sajjadi; Seyed Abass Tabatabai; Majid Heidarpour
Volume 5, Issue 3 , June 2010, , Pages 158-162
Abstract
Gardner's syndrome is an autosomal dominant inherited disorder. Familial polyposis of the colon, osteomas, hypertrophy of the retinal-pigmented layer and a multitude of soft tissue tumors are characteristic features. The syndrome may be presented with colonic or extracolonic symptoms. A 75-year-old ...
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Gardner's syndrome is an autosomal dominant inherited disorder. Familial polyposis of the colon, osteomas, hypertrophy of the retinal-pigmented layer and a multitude of soft tissue tumors are characteristic features. The syndrome may be presented with colonic or extracolonic symptoms. A 75-year-old male patient presented to Al-zahra Clinic with diffuse abdominal pain. An abdominal surgery was performed on him due to invasive abdominal mass. The surgical specimen was examined by H&E and immunohistochemical staining. The final diagnosis was fibromatosis. There was a history of gardner’s syndrome in his family. Colonoscopy was done to confirm the diagnosis of gardner’s syndrome. The diagnosis of gardner’s syndrome was made according to following findings: abdominal fibromatosis, multiple jaw osteomas and polyposis coli. The patient with gardner’s syndrome can present with abdominal fibromatosis even in an old age. In IHC staining CD117 was seen with coarse granular cytoplasmic pattern in fibromatosis, and so, this pattern of CD117 staining can be a clue to the diagnosis of fibromatosis.
Parvin Rajabi; Mohammad Aboutalebdokht; Mitra Heidarpour; Ali Asilian; Fatemeh Rajabi
Volume 2, Issue 1 , January 2007, , Pages 7-10
Abstract
Background and Objective: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are two common tumors of the skin. In some cases, distinction between BCC and SCC can be difficult. This study aimed to clarify this uncertainty through immunohistochemical analysis. In this respect, epithelial membrane ...
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Background and Objective: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are two common tumors of the skin. In some cases, distinction between BCC and SCC can be difficult. This study aimed to clarify this uncertainty through immunohistochemical analysis. In this respect, epithelial membrane antigen (EMA) and Ber-Ep4 are the two immunohistochemical markers on which we focus in differentiating skin BCC from SCC. Materials and Methods: Archived paraffin-embedded tissue samples of BCC (n = 40) and SCC (n=40) were stained immunohistochemically using Ber-Ep4 and EMA antibodies. Results: It was found out that 37 (92.5%) out of the BCC samples stained positive for Ber-Ep4 and 2.5% of SCC samples showed positive staining. The majority of SCC group (37 out of 40) expressed EMA, while 5% of BCC samples showed positive staining. Conclusion: Distinction of BCC and SCC of the skin can be readily achieved through Ber-Ep4 and EMA immunohistochemical markers. Regarding potential false positive and negative results through immunostaining techniques, we may recommend the use of these two antibodies together.
Mitra Heidarpour; Parvin Rajabi; Amin Eftekhari; Hamid Reza Ghasemibasir
Volume 1, Issue 4 , September 2006, , Pages 173-176
Abstract
Although acrometastases are rare but clinically they are considered important. Their etiology is quite different from the metastases to other sites; bronchogenic carcinoma is by far the most frequent case. The prognosis is always similar to metastatic bronchial cancer with an average survival of three ...
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Although acrometastases are rare but clinically they are considered important. Their etiology is quite different from the metastases to other sites; bronchogenic carcinoma is by far the most frequent case. The prognosis is always similar to metastatic bronchial cancer with an average survival of three months. Treatment may involve distal digital amputation or antalgic radiotherapy. The main differential diagnosis is aggressive digital papillary adenocarcinomas (ADPA) that is a rare sweat gland neoplasm. A case of bronchogenic carcinoma with metastasis to the index finger is presented. The metastasis was located in the distal phalanx of the left index finger. Although acrometastasis is rare, it should be considered in the differential diagnosis of distal lesions, especially in elderly patients.
