Alireza Abdollahi; Mohammad Reza Jalali Nadoushan
Volume 6, Issue 2 , April 2011, , Pages 53-55
Alireza Abdollahi; Mohammad Reza Jalali Nadoushan
Volume 6, Issue 1 , January 2011, , Pages 201-201
Mehrdad Roghani; Mohammad Taghi Joghataie; Mohammad Reza Jalali Nadoushan; Tourandokht Baluchnejadmojarad; Farshad Roghani Dehkordi
Volume 1, Issue 4 , September 2006, , Pages 135-140
Abstract
Background and Objective: Although diabetes mellitus is known to be one of the risk factors for dementia but neuropathic changes in the brain of diabetic patients have not been completely revealed. Therefore, this research study was done to evaluate structural changes in pyramidal neurons of hippocampal ...
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Background and Objective: Although diabetes mellitus is known to be one of the risk factors for dementia but neuropathic changes in the brain of diabetic patients have not been completely revealed. Therefore, this research study was done to evaluate structural changes in pyramidal neurons of hippocampal CA1 area of male diabetic rats using Golgi-impregnation method. Materials and Methods: Male Wistar rats were randomly divided into control and diabetic groups. For induction of diabetes, streptozotocin (STZ) was injected (i.p.) at a single dose of 60 mg/kg. At the end of 1st and 2nd months, rats were transcardially perfused and Golgi-impregnation method was used to evaluate the changes of dendritic spines in CA1 area. Results: It was found out that there was a significant reduction in mean density of pyramidal neuron dendritic spines after 1 and 2 months in diabetic group as compared to age-matched controls (p
Horieh Saderi; Parviz Owlia; Mohammad Reza Jalali Nadoushan; Farid Zaeri; Elaheh Zandieh
Volume 1, Issue 3 , June 2006, , Pages 99-104
Abstract
Background and Objectives: This study was designed as a retrospective study on urine samples during three years in Shaheed Mostafa Khomeini Hospital to determine demographic characteristics of patients with urinary tract infection (UTI), microbial etiology, and susceptibility of isolated bacteria to ...
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Background and Objectives: This study was designed as a retrospective study on urine samples during three years in Shaheed Mostafa Khomeini Hospital to determine demographic characteristics of patients with urinary tract infection (UTI), microbial etiology, and susceptibility of isolated bacteria to antibiotics. Materials and Methods: All urines fulfilling the criteria for significant bacteriuria (>104 colonyforming units/ml of urine) were included in the study. Isolation and identification of bacteria was performed by standard method and susceptibility testing was determined by disk diffusion method according to NCCLS guideline. A total of 909 patients with urinary tract infection were enrolled in this study. Results: Mean age of the patients was 53.2 years. In addition, females were affected more often than males (female/male sex ratio was 2.22). Meanwhile, considering all strains, 79.5% were Gram-negative bacilli and 67.7% were Enterobacteriaceae. Furthermore, E.coli and Klebsiella spp represented the most common Gram-negative and Enterococci and S. aureus represented the most frequent Gram-positive isolates. The four most frequently isolated bacteria were E. coli (52.1%), Enterococci (10.5%), klebsiella spp. (10.3%), and pseudomonas spp. (9.4%). In addition, E. coli was significantly more common in females (56.6%) than in males (42.2%) and in outpatients (57.4%) than in inpatients (47.4%). The proportion of pseudomonas spp. was significantly higher in males (17.7%) than in females (5.6%). Enterococci were significantly more common in inpatients (12.5%) than in outpatients (8.4%). Altogether, the rate of susceptibility of all UTI pathogens was very low to ampicillin (6.9%) and high to cefotaxime (83.6%) and ciprofloxacin (78.2%). Urinary pathogens isolated from female patients and outpatients were more susceptible to most of examined antibiotics than those isolated from males and inpatients. Conclusion: It was found out that degrees for antibiotic resistance of urinary pathogens are alarming and show the necessity of keeping up the monitoring of antibiotics susceptibility in UTI isolates and restricting antibiotic consumption in our population.
Seyed Mohammad Bagher AkhaviRad; Ali Davati; Mohammad Reza Jalali Nadoushan; Mehdi Abedini
Volume 1, Issue 3 , June 2006, , Pages 113-116
Abstract
Background and Objective: Wilms’ tumor has been recognized as the most common primary malignancy of kidney at childhood, comprises 5-6% of tumors in this period, and manifests itself with various clinical symptoms. Since there have been no sufficient studies in this field in Iran, therefore, this ...
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Background and Objective: Wilms’ tumor has been recognized as the most common primary malignancy of kidney at childhood, comprises 5-6% of tumors in this period, and manifests itself with various clinical symptoms. Since there have been no sufficient studies in this field in Iran, therefore, this study was conducted to investigate its histopathology and clinical symptoms. Materials and Methods: This study was carried out on existing data from 66 children with a diagnosis of Wilms’ tumor at children hospital during the years 1984-1999. In this regard, personal and disease-related characteristics of patients including age, gender, tumor stage, histopathology, and involved kidney were evaluated and SPSS software and Chi-square, t-test, ANOVA, and Mann- Whitney U test were used for data analysis. Results: The most common age of disease incidence was 2-4 years. In this regard, girl/boy ratio was 1.5. Meanwhile, the prevalence of an abdominal mass as the most common symptom was 83.3%. Left kidney was involved in 47% of cases and 55 of patients had a favorable histology. In addition, there was a significant correlation between site of kidney involvement and tumor histology (p<0.005). Conclusion: Considering the achieved advances in the diagnosis and treatment of Wilms’ tumor, prompt identification with regard to clinical symptoms can have a valuable role in its effective management.
Mohammad Reza Jalali Nadoushan; Ehsanollah Ghorbanian; Touraj Taheri
Volume 1, Issue 1 , January 2006, , Pages 17-20
Abstract
Objective: Transitional cell carcinoma (TCC) of the urinary bladder is the second common cancer of the genitourinary tract. Several parameters such as clinical and pathological parameters, molecular factors, and etc play a role in determination of prognosis and type of treatment. In this research study, ...
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Objective: Transitional cell carcinoma (TCC) of the urinary bladder is the second common cancer of the genitourinary tract. Several parameters such as clinical and pathological parameters, molecular factors, and etc play a role in determination of prognosis and type of treatment. In this research study, the relationship between grade and MDM2 oncoprotein overexpression in TCC of bladder was evaluated. Material and Methods: This cross-sectional study was carried out on 75 paraffinembedded tissue blocks (deposited in Pathology Department) from patients with TCC of urinary bladder from 2002 to 2005. In this respect, 3 μm sections were taken from each block. In one of the sections, grade of tumor was determined according to WHO/ISUP criteria using hematoxylin-eosin staining method. In another section, percent of MDM2 positive cells were determined by microscopic observation of 100 cells in each section using immunohistochemical technique and specific antibody. Results: Mean of MDM2 positive cells was %9.08 ± 4.7. In addition, mean of MDM2 positive cells in low malignant potential tissue (grade I), low grade tissue (grade II), and high grade tissue (grade III) was %3.6 ± 2.2, %8.2 ±3.5, and %13.1 ± 3.4 respectively. Meanwhile, a significant relationship was found out between grade and overexpression of MDM2 oncoprotein (p = 0.012). Conclusion: Overexpression of MDM2 oncoprotein exhibits a direct relationship with grade of TCC of the urinary bladder. The obtained results were consistent with the most previous studies. Therefore, through performing studies with a greater follow-up and entailing a larger population of patients, overexpression of MDM2 oncoprotein could be used as a prognostic parameter in TCC of urinary bladder.
