Etrat Javadi Rad; Azadeh Almasi; Behzad Khoshraftar
Volume 7, Issue 1 , January 2012, , Pages 38-42
Abstract
We describe a rare case of laryngeal fasciitis ossificans. A 58-year-old man presented with hoarseness and a nodule was found in the larynx. Excisional biopsy was performed, and follow-up laryngoscopy showed complete resolution of this reactive lesion, and normal laryngeal function. The 0.6 cm diameter ...
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We describe a rare case of laryngeal fasciitis ossificans. A 58-year-old man presented with hoarseness and a nodule was found in the larynx. Excisional biopsy was performed, and follow-up laryngoscopy showed complete resolution of this reactive lesion, and normal laryngeal function. The 0.6 cm diameter nodule was well circumscribed and histologically, the lesion was composed of uniform woven bone trabeculae with rimming of osteoblasts and cellular stroma. At the periphery, uniform spindle cells actively proliferated in edematous stroma. Spindle cells were immunoreactive for vimentin and α-smooth muscle actin, suggesting myofibroblastic differentiation. Fasciitis ossificans is histologically identical to myositis ossificans, but tends to present no zonation phenomenon. Fasciitis ossificans is a rare form of heterotopic bone formation, commonly presenting with signs of local inflammation or pain. This patient's successful outcome suggests that conservative resection may be both diagnostic and curative.
Etrat Javadi Rad; Seyed Hamid Madani; Sedigheh Khazaei; Mahtab Rahbar
Volume 5, Issue 4 , September 2010, , Pages 167-172
Abstract
Background and Objectives: Uterine smooth muscle tumors are the most common human neoplasm .They are divided clinically as benign and malignant but there is another group of lesions which is difficult to place in these two categories ,so-called smooth muscle tumors of uncertain ...
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Background and Objectives: Uterine smooth muscle tumors are the most common human neoplasm .They are divided clinically as benign and malignant but there is another group of lesions which is difficult to place in these two categories ,so-called smooth muscle tumors of uncertain malignant potential (STUMP) and differentiation of these tumors on the basis of H&E staining is impossible . The goal of this study was finding of distinguishing objective biomarkers and a survey of proliferation markers comparing these three groups of tumors. Materials & Methods: Twenty one cases in each group of above mentioned tumors were selected randomly (63cases in total ) from Pathobiology laboratories and studied by using immunohistochemistry (IHC) staining for Ki_67 expression and special Argyrophilic Nucleolar Organizing Regions (AgNOR) staining method. Results : Ki_67 was expressed in 63.15% of leiomyosarcomas (LMS), 4.76% of STUMPs and 0% of leiomyoma group. Ki_67 expression between LMS and STUMP ,and also between LMS and leiomyoma were significantly different(P<0.0001).Mean AgNOR dots were2.55±0.03, 2.55, 0.66,4.04, and 8.12 ±0.13 in leiomyoma, STUMP and leiomyosarcoma,respectively. Significant differences between the three groups were observed (P<0.0001). Conclusion: AgNOR and Ki_67(MIB1) proliferation markers expression between LMS and STUMP were significantly different. Due to difficulty in differentiation LMS from STUMP, finding objective biomarkers is useful and practical. For this purpose, the present study recommend, Ki_67 and AgNOR staining which is a reliable, simple and rapid method.
Seyed Hamid Madani; Etrat Javadi Rad; Ahmad Faramarzi
Volume 4, Issue 3 , June 2009, , Pages 137-140
Abstract
Kaposiform hemangioendothelioma (KHE) appears as a single lesion at birth or early infancy in an equal sex ratio. A rare aggressive vascular proliferation has been recognized as a separate entity from other childhood vascular neoplasm. A 3-year-old Iranian boy with a rapidly enlarging mass in ...
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Kaposiform hemangioendothelioma (KHE) appears as a single lesion at birth or early infancy in an equal sex ratio. A rare aggressive vascular proliferation has been recognized as a separate entity from other childhood vascular neoplasm. A 3-year-old Iranian boy with a rapidly enlarging mass in his (posterior aspect of skull at the midline) skull was present here. Physical examination revealed a dark-red, firm mass measuring 5 × 4.5 cm in the posterior aspect of skull. No association with Kasabach- Merritt syndrome (KMS) was observed despite its size. Histologically, KHE was composed of infiltrating nodules with slitlike or crescentic vessels that are poorly canalized and lined by spindled endothelium cells. Immunohistochemically, both spindle and epithelioid cells were immunoreactive for CD34 and CD31, while negative for EMA, cytokeratin or S100 protein. α- SMA were detected in pericytes surrounding spindle cells. Recurrence occurred 2 month after first operation. Wide resection was performed at second operation and the patient was still alive during the 1-year follow- up period.
Mohsen Emami Aleagha; Etrat Javadi Rad; Siamak Shariat Torbaghan
Volume 4, Issue 2 , April 2009, , Pages 88-91
Abstract
Littoral cell angioma is a splenic vascular tumor of splenic sinus lining cells that is considered benign in general. This report describes a case of littoral cell angioma with no malignant histological features. The lesion is composed of anastomosing vascular channels resembling splenic sinus; ...
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Littoral cell angioma is a splenic vascular tumor of splenic sinus lining cells that is considered benign in general. This report describes a case of littoral cell angioma with no malignant histological features. The lesion is composed of anastomosing vascular channels resembling splenic sinus; they are lined by endothelial cells which show mitotic activity very rare. Immunohistochemically, the tumor cells were positive for both endothelial (Factor VIII-AG, CD34) and histiocytic markers (KP1 or CD68). The morphologic and immunohistochemical findings in this tumor confirm the presence of dual (endothelial / histiocytic) characteristics of the reticuloendothelial cells lining the splenic sinus, justifying the term littoral cell angioma.